Yuhei Mizunoe

Profile Information

Degree: 薬科学（博士）(東京理科大学)

researchmap Member ID: B000282711

Research Interests

Research Areas

Research History

Apr, 2023 - Present

Assistant Professor, Faculty of Pharmaceutical Sciences Department of Medicinal and Life Science, Tokyo University of Science
Apr, 2022 - Mar, 2023

Organization for Research Advancement Research Institute for Biomedical Science, Tokyo University of Science
Apr, 2019 - Mar, 2022

日本学術振興会特別研究員PD
Apr, 2018 - Mar, 2019

Department of Internal Medicine (Endocrinology and Metabolism), Faculty of Medicine, University of Tsukuba

Committee Memberships

Mar, 2023 - Present

評議員, 日本基礎老化学会

Awards

Jun, 2015

若手奨励賞, 日本基礎老化学会

水之江雄平

Papers

Genetic and Functional Analyses of Patients with Marked Hypo-High-Density Lipoprotein Cholesterolemia.

Yasuhisa Furuta, Yoshinori Osaki, Yoshimi Nakagawa, Song-Iee Han, Masaya Araki, Akito Shikama, Nami Ohuchi, Daichi Yamazaki, Erika Matsuda, Seitaro Nohara …

Journal of atherosclerosis and thrombosis, Mar 28, 2024
Obesity-induced PARIS (ZNF746) accumulation in adipose progenitor cells leads to attenuated mitochondrial biogenesis and impaired adipogenesis.

Kazuki Hachiya, Yusuke Deguchi, Takuro Hirata, Tomoya Arikawa, Hiroto Fukai, Tatsuhiro Esashi, Kota Nagasawa, Yuhei Mizunoe, Yuka Nozaki, Masaki Kobayashi …

Scientific reports, 13(1) 22990-22990, Dec 27, 2023
Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at endoplasmic reticulum monitoring and regulating fatty acids.

Song-Iee Han, Masanori Nakakuki, Yoshimi Nakagawa, Yunong Wang, Masaya Araki, Yuta Yamamoto, Hiroaki Tokiwa, Hiroyuki Takeda, Yuhei Mizunoe, Kaori Motomura …

PNAS nexus, 2(11) pgad351, Nov, 2023
Effect of mitochondrial quantity and quality controls in white adipose tissue on healthy lifespan: Essential roles of GH/IGF-1-independent pathways in caloric restriction-mediated metabolic remodeling.

Yuina Otani, Yuka Nozaki, Yuhei Mizunoe, Masaki Kobayashi, Yoshikazu Higami

Pathology international, Aug 22, 2023
Identification of key microRNAs regulating ELOVL6 and glioblastoma tumorigenesis

Nurani Istiqamah, Takashi Matsuzaka, Momo Shimizu, Kaori Motomura, Hiroshi Ohno, Shiho Hasebe, Rahul Sharma, Yuka Okajima, Erika Matsuda, Song-Iee Han …

BBA Advances, 3 100078-100078, 2023
Hepatocyte- or macrophage-specific SREBP-1a deficiency in mice exacerbates methionine- and choline-deficient diet-induced nonalcoholic fatty liver disease.

Masaya Araki, Yoshimi Nakagawa, Hodaka Saito, Yasunari Yamada, Song-Iee Han, Yuhei Mizunoe, Hiroshi Ohno, Takafumi Miyamoto, Motohiro Sekiya, Takashi Matsuzaka …

American journal of physiology. Gastrointestinal and liver physiology, 323(6) G627-G639, Dec 1, 2022
Long-Term Dietary Taurine Lowers Plasma Levels of Cholesterol and Bile Acids

Ryoma Tagawa, kobayashi masaki, Misako Sakurai, Maho Yoshida, Hiroki Kaneko, Yuhei Mizunoe, Yuka Nozaki, Naoyuki Okita, Yuka Sudo, Yoshikazu Higami

International Journal of Molecular Sciences, 23(3), Feb, 2022 Peer-reviewed
Morphological and functional adaptation of pancreatic islet blood vessels to insulin resistance is impaired in diabetic db/db mice.

Yuka Okajima, Takashi Matsuzaka, Shun Miyazaki, Kaori Motomura, Hiroshi Ohno, Rahul Sharma, Takuya Shimura, Nurani Istiqamah, Song-Iee Han, Yuhei Mizunoe …

Biochimica et biophysica acta. Molecular basis of disease, 1868(4) 166339-166339, Jan 8, 2022 Peer-reviewed
CREBH Systemically Regulates Lipid Metabolism by Modulating and Integrating Cellular Functions.

Yoshimi Nakagawa, Masaya Araki, Song-Iee Han, Yuhei Mizunoe, Hitoshi Shimano

Nutrients, 13(9), Sep 15, 2021 Peer-reviewed
Prolonged caloric restriction ameliorates age-related atrophy in slow and fast muscle fibers of rat soleus muscle.

Yuhei Mizunoe, Masaki Kobayashi, Hiroki Saito, Akifumi Goto, Ryota Migitaka, Kumi Miura, Naoyuki Okita, Yuka Sudo, Ryoma Tagawa, Miki Yoshida …

Experimental gerontology, 111519-111519, Aug 17, 2021 Peer-reviewedLead author
Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at ER monitoring and regulating fatty acids

Han SI, Nakakuki M, Nakagawa Y, Wang Y, Araki M, Yamamoto Y, Tokiwa H, Takeda H, Mizunoe Y, Motomura K …

Aug, 2021
Rapid manipulation of mitochondrial morphology in a living cell with iCMM

Takafumi Miyamoto, Hideki Uosaki, Yuhei Mizunoe, Song-Iee Han, Satoi Goto, Daisuke Yamanaka, Masato Masuda, Yosuke Yoneyama, Hideki Nakamura, Naoko Hattori …

Cell Reports Methods, 100052-100052, Jul, 2021 Peer-reviewed
Starvation-induced transcription factor CREBH negatively governs body growth by controlling GH signaling.

Yoshimi Nakagawa, Kae Kumagai, Song-Iee Han, Yuhei Mizunoe, Masaya Araki, Seiya Mizuno, Hiroshi Ohno, Kazuya Matsuo, Yasunari Yamada, Jun-Dal Kim …

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 35(6) e21663, Jun, 2021 Peer-reviewed
Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition.

Yoshimi Nakagawa, Yunong Wang, Song-Iee Han, Kanako Okuda, Asayo Oishi, Yuka Yagishita, Kae Kumagai, Hiroshi Ohno, Yoshinori Osaki, Yuhei Mizunoe …

Cellular and molecular gastroenterology and hepatology, Nov 24, 2020 Peer-reviewed
Srebp-1c/Fgf21/Pgc-1α Axis Regulated by Leptin Signaling in Adipocytes-Possible Mechanism of Caloric Restriction-Associated Metabolic Remodeling of White Adipose Tissue.

Masaki Kobayashi, Seira Uta, Minami Otsubo, Yusuke Deguchi, Ryoma Tagawa, Yuhei Mizunoe, Yoshimi Nakagawa, Hitoshi Shimano, Yoshikazu Higami

Nutrients, 12(7), Jul 10, 2020 Peer-reviewed
Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl-Chain Length and Hepatic Insulin Sensitivity in Mice.

Takashi Matsuzaka, Motoko Kuba, Saori Koyasu, Yuta Yamamoto, Kaori Motomura, Sundaram Arulmozhiraja, Hiroshi Ohno, Rahul Sharma, Takuya Shimura, Yuka Okajima …

Hepatology (Baltimore, Md.), 71(5) 1609-1625, May, 2020 Peer-reviewed
転写因子SREBP-1aによる腸管内脂質制御が腸管内部構造に与える影響の検討

荒木雅弥, 中川嘉, 韓松伊, 水之江雄平, 王農雨, 松坂賢, 関谷元博, 矢作直也, 島野仁

日本栄養・食糧学会大会講演要旨集, 74回 291-291, Apr, 2020
WWP1 knockout in mice exacerbates obesity-related phenotypes in white adipose tissue but improves whole-body glucose metabolism.

Shunsuke Hoshino, Masaki Kobayashi, Ryoma Tagawa, Ryutaro Konno, Takuro Abe, Kazuhiro Furuya, Kumi Miura, Hiroki Wakasawa, Naoyuki Okita, Yuka Sudo …

FEBS open bio, 10(3) 306-315, Mar, 2020 Peer-reviewed
CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms.

Aoi Satoh, Song-Iee Han, Masaya Araki, Yoshimi Nakagawa, Hiroshi Ohno, Yuhei Mizunoe, Kae Kumagai, Yuki Murayama, Yoshinori Osaki, Hitoshi Iwasaki …

iScience, 23(3) 100930-100930, Feb 21, 2020 Peer-reviewed
Cathepsin B overexpression induces degradation of perilipin 1 to cause lipid metabolism dysfunction in adipocytes.

Yuhei Mizunoe, Masaki Kobayashi, Shunsuke Hoshino, Ryoma Tagawa, Rei Itagawa, Ayana Hoshino, Naoyuki Okita, Yuka Sudo, Yoshimi Nakagawa, Hitoshi Shimano …

Scientific reports, 10(1) 634-634, Jan 20, 2020 Peer-reviewedLead author

Misc.

Aging / Lifespan Control by Adipose Tissue

YAKUGAKU ZASSHI, 144(4) 411-417, Apr, 2024 Peer-reviewed
Regulation of adipocyte quality by lysosomes and mitochondria

45(1) 31-37, Jan, 2021 Peer-reviewed
Autophagy in adipose tissue AUTOPHAGY: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Volume 9 to be published by Elsevier/Academic Press. Autophagy, M.A.HAYAT (ed)

Yuhei Mizunoe, Yuka Sudo, Naoyuki Okita, Yoshikazu Higami

10 147-156, 2016
肥満症脂肪組織におけるリソソーム機能障害とオートファジーに与える影響

水之江雄平, 須藤結香, 平岡秀規, 沖田直之, 樋上賀一

基礎老化研究, 39(3) 35-38, 2015

Presentations

Lysosomal dysfunction in obese adipose tissue

Yuhei Mizunoe, Masaki Kobayashi, Yoshikazu Higami, Yoshimi Nakagawa, Hitoshi Shimano

30th Spring International Conference of the Korean Society for Gerontology, Jun 26, 2019
肥満症脂肪組織における脂肪滴局在タンパク質ペリリピン1減少のメカニズム解明（ポスター）

水之江, 雄平, 中川嘉, 島野, 仁, 小林正樹, 樋上賀一

第42回日本基礎老化学会大会, Jun 7, 2019
臓器特異的SREBP-1a欠損マウスを用いたSREBP-1aの肝臓における機能解（ポスター）

荒木, 雅弥, 中川嘉, 韓, 松伊, 水之江雄平, 関谷元博, 松坂賢, 島野, 仁

第56回日本臨床分子医学会学術集会, Apr 26, 2019
新規プロテアーゼによるSREBP-1活性化制御機構の解明（ポスター）

韓, 松伊, 水之江雄平, 中川嘉, 関谷元博, 松坂賢, 島野, 仁

第56回日本臨床分子医学会学術集会, Apr 26, 2019
脂肪酸伸長酵素Elovl6の神経新生における役割（ポスター）

大野博, 松坂賢, 志村拓哉, 本村香織, 水之江雄平, 韓, 松伊, 宮本崇史, 関谷元博, 中川嘉, 島野, 仁

第56回日本臨床分子医学会学術集会, Apr 26, 2019
肝臓肝臓内フルクトース代謝におけるChREBP媒介のFGF21分泌に対するCREBHの重要性

王雨農, 中川嘉, 韓松伊, 佐藤葵, 荒木雅弥, 水之江雄平, 関谷元博, 松坂賢, Shimano, Hitoshi

第33回糖尿病合併症学会, Oct 19, 2018
リソソーム機能異常が脂肪滴局在タンパク質ペリリピンに及ぼす影響の解析（ポスター）

水之江雄平, 樋上賀一, 小林正樹, 星野駿介, 中川嘉, 島野, 仁

第39回日本肥満学会, Oct 7, 2018
Development of an Obesity Pathology affected by Lysosomal Dysfunction

Rei ITAGAWA, Yuhei MIZUNOE, Masaki KOBAYASHI, Yoshikazu HIGAMI

第40回日本基礎老化学会大会, Jun, 2017
Involvement of lysosomal dysfunction in pathologies associated with obesity in white adipose tissue.

Kobayashi M, Mizunoe Y, Higami Y

The 8th International Symposium on Autophagy, May, 2017
肥満症が骨格筋に及ぼす影響

平岡秀規, 水之江雄平, 小林正樹, 樋上賀一

日本薬学会・日本薬学会第137年会, Mar, 2017
天然由来二糖類トレハロースの新規細胞防御機構の解明と代謝性疾患への応用

名取大輝, 水之江雄平, 樋上賀一

第 37 回日本肥満学会, Nov, 2016
肥満症脂肪組織におけるオートファジー・リソソーム障害

水之江雄平, 樋上賀一

第 37 回日本肥満学会, Nov, 2016
タウリンが脂肪細胞のオートファジーに与える影響

金子弘輝, 水之江雄平, 井前正人, 須藤結香, 樋上賀一

日本基礎老化学会・第39回日本基礎老化学会大会, Apr, 2016
ROS-associated lysosomal dysfunction impairs autophagy flux in adipocytes

水之江雄平

Japan-Korea Joint Symposium in Jeju island, Jun, 2014

Professional Memberships

Apr, 2023

日本動脈硬化学会
Apr, 2022

日本免疫学会
JAPAN SOCIETY FOR THE STUDY OF OBESITY
JAPAN SOCIETY FOR BIOMEDICAL GERONTOLOGY

Research Projects

”免疫様脂肪細胞”によるリソソーム機能障害と肥満症病態基盤の形成

科学研究費助成事業, 若手研究, 日本学術振興会, Apr, 2023 - Mar, 2025

水之江雄平
骨格筋でのコレステロール合成阻害が導く新たなコレステロール代謝機構

特別研究員奨励費, Apr, 2019 - Mar, 2022

水之江雄平
加齢によるリソソーム機能破綻が骨格筋に及ぼす影響の解明とその制御法の開発

若手研究, 筑波大学, Apr, 2018 - Mar, 2021

水之江雄平
骨格筋特異的コレステロール破綻が横紋筋融解症を発症させる分子メカニズムの解明

研究奨励助成, 公益財団法人小野医学研究財団, Apr, 2019 - Mar, 2020

水之江雄平
サルコペニアにおける筋繊維タイプ変化・代謝変換とオートファジー相互作用機構の解明

研究活動スタート支援, 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), Aug, 2017 - Mar, 2018

水之江雄平

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Research Interests

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Research History

Committee Memberships

Awards

Papers

Misc.

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