2016年
Acute Corneal Toxicity of Diquas
PHARMACOLOGY
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発表資料
回数 : 311
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- 巻
- 98
- 号
- 1-2
- 開始ページ
- 56
- 終了ページ
- 61
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1159/000445691
- 出版者・発行元
- KARGER
Aim: This study aimed to investigate acute corneal toxicity of commercially available diquafosol 3% ophthalmic solution (Diquas (R)), which contains C12 benzalkonium chloride (BAC) as a preservative. Methods: Corneal transepithelial electrical resistance (TER) changes after a 60-second exposure to Diquas (R) (diquafosol 3% preserved with 0.0075% C12 BAC); 0.0075% C12 BAC and 0.0075% C12, C14, C16 BAC mixture were measured in living rabbits. Corneal damage was also examined by scanning electron microscopy (SEM). Hank's balanced salt solution (HBSS) was used as a control. Results: Diquas r and 0.0075% C12 BAC did not produce any significant decrease in the corneal TER as compared to the HBSS control eyes. There was a significant decrease in the corneal TER after exposure of the cornea to the 0.0075% C12, C14, C16 BAC mixture (p < 0.01). SEM revealed that the superficial cells of the corneas exposed to the 0.0075% BAC mixture were damaged and exhibited degenerated microvilli. Conversely, the superficial cells of corneas exposed to Diquas r or 0.0075% C12 BAC appeared normal and had normal microvilli under SEM examinations. Conclusion: The acute corneal toxicity of Diquas r is less than that of the 0.0075% BAC mixture. Diquas r preserved with 0.0075% C12 BAC did not show acute corneal toxicity. (C) 2016 S. Karger AG, Basel
- リンク情報
- ID情報
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- DOI : 10.1159/000445691
- ISSN : 0031-7012
- eISSN : 1423-0313
- PubMed ID : 27078164
- Web of Science ID : WOS:000377159900009