論文

査読有り
2015年12月

Non-autonomous overgrowth by oncogenic niche cells: Cellular cooperation and competition in tumorigenesis

CANCER SCIENCE
  • Masato Enomoto
  • ,
  • John Vaughen
  • ,
  • Tatsushi Igaki

106
12
開始ページ
1651
終了ページ
1658
記述言語
英語
掲載種別
DOI
10.1111/cas.12816
出版者・発行元
WILEY-BLACKWELL

Tumor progression is classically viewed as the Darwinian evolution of subclones that sequentially acquire genetic mutations and autonomously overproliferate. However, growing evidence suggests that tumor microenvironment and subclone heterogeneity contribute to non-autonomous tumor progression. Recent Drosophila studies revealed a common mechanism by which clones of genetically altered cells trigger non-autonomous overgrowth. Such "oncogenic niche cells" (ONCs) do not overgrow but instead stimulate neighbor overgrowth and metastasis. Establishment of ONCs depends on competition and cooperation between heterogeneous cell populations. This review characterizes diverse ONCs identified in Drosophila and describes the genetic basis of non-autonomous tumor progression. Similar mechanisms may contribute to mammalian cancer progression and recurrence.

Web of Science ® 被引用回数 : 19

リンク情報
DOI
https://doi.org/10.1111/cas.12816
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26362609
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000368249400001&DestApp=WOS_CPL

エクスポート
BibTeX RIS