高橋巌 (Iwao Takahashi) - マイポータル

基本情報

所属: 岩手医科大学薬学部助教

研究者番号: 20552912
J-GLOBAL ID: 202001016442506361
researchmap会員ID: R000012679

論文

The a subunit isoforms of V-ATPase are involved in glucose-dependent trafficking of insulin granules.

Mizuki Sekiya, Mayumi Nakanishi-Matsui, Naomi Matsumoto, Iwao Takahashi, Tomohito Hanasaka, Eri Ishiyama-Matsuura, Makoto Araki, Tomohiko Wakayama, Koji Nata

Scientific reports 15(1) 18982-18982 2025年5月30日
A newly identified compound activating UCP1 inhibits obesity and its related metabolic disorders.

Ken Onodera, Yutaka Hasegawa, Nozomi Yokota, Shukuko Tamura, Hirofumi Kinno, Iwao Takahashi, Hiraku Chiba, Hirotatsu Kojima, Hideki Katagiri, Koji Nata …

Obesity (Silver Spring, Md.) 32(2) 324-338 2024年
Importance of Heparan Sulfate Proteoglycans in Pancreatic Islets and β-Cells.

Iwao Takahashi

International journal of molecular sciences 23(20) 2022年10月筆頭著者最終著者責任著者
インスリン産生膵β細胞機能におけるヘパラン硫酸プロテオグリカンの役割

Iwao Takahashi

Trends in Glycoscience and Glycotechnology 33(195) J109-J113 2021年9月25日筆頭著者最終著者責任著者
Role of Heparan Sulfate Proteoglycans in Insulin-producing Pancreatic β-cell Function

Iwao Takahashi

Trends in Glycoscience and Glycotechnology 33(195) E109-E114 2021年9月25日筆頭著者最終著者責任著者
Effects of heparan sulfate proteoglycan syndecan-4 on the insulin secretory response in a mouse pancreatic β-cell line, MIN6.

Iwao Takahashi, Shuhei Yamada, Koji Nata

Molecular and cellular endocrinology 470 142-150 2018年7月15日筆頭著者責任著者
Involvement of heparan sulfate 3-O-sulfotransferase isoform-1 in the insulin secretion pathway.

Iwao Takahashi, Kazuaki Ohashi, Koji Nata

Journal of diabetes investigation 3(4) 362-70 2012年8月20日筆頭著者
Identification of a major enzyme for the synthesis and hydrolysis of cyclic ADP-ribose in amphibian cells and evolutional conservation of the enzyme from human to invertebrate.

Takayuki Ikeda, Shin Takasawa, Naoya Noguchi, Koji Nata, Akiyo Yamauchi, Iwao Takahashi, Takeo Yoshikawa, Akira Sugawara, Hideto Yonekura, Hiroshi Okamoto

Molecular and cellular biochemistry 366(1月2日) 69-80 2012年
A novel ryanodine receptor expressed in pancreatic islets by alternative splicing from type 2 ryanodine receptor gene.

Shin Takasawa, Michio Kuroki, Koji Nata, Naoya Noguchi, Takayuki Ikeda, Akiyo Yamauchi, Hiroyo Ota, Asako Itaya-Hironaka, Sumiyo Sakuramoto-Tsuchida, Iwao Takahashi …

Biochemical and biophysical research communications 397(2) 140-5 2010年6月25日
Important role of heparan sulfate in postnatal islet growth and insulin secretion.

Iwao Takahashi, Naoya Noguchi, Koji Nata, Shuhei Yamada, Tomoyuki Kaneiwa, Shuji Mizumoto, Takayuki Ikeda, Kazushi Sugihara, Masahide Asano, Takeo Yoshikawa …

Biochemical and biophysical research communications 383(1) 113-8 2009年5月22日筆頭著者
Thiazolidinediones inhibit REG Ialpha gene transcription in gastrointestinal cancer cells.

Akiyo Yamauchi, Iwao Takahashi, Shin Takasawa, Koji Nata, Naoya Noguchi, Takayuki Ikeda, Takeo Yoshikawa, Nausheen J Shervani, Iwao Suzuki, Akira Uruno …

Biochemical and biophysical research communications 379(3) 743-8 2009年2月13日筆頭著者
FKBP12.6 disruption impairs glucose-induced insulin secretion.

Naoya Noguchi, Takeo Yoshikawa, Takayuki Ikeda, Iwao Takahashi, Nausheen Jamal Shervani, Akira Uruno, Akiyo Yamauchi, Koji Nata, Shin Takasawa, Hiroshi Okamoto …

Biochemical and biophysical research communications 371(4) 735-40 2008年7月11日
Cyclin D1 activation through ATF-2 in Reg-induced pancreatic beta-cell regeneration.

Shin Takasawa, Takayuki Ikeda, Takako Akiyama, Koji Nata, Kei Nakagawa, Nausheen J Shervani, Naoya Noguchi, Shoko Murakami-Kawaguchi, Akiyo Yamauchi, Iwao Takahashi …

FEBS letters 580(2) 585-91 2006年1月23日
Genomic organization, chromosomal localization, and promoter of human gene for FK506-binding protein 12.6.

Tetsuya Nakazawa, Shin Takasawa, Naoya Noguchi, Koji Nata, Akira Tohgo, Mitsuko Mori, Kan-ichi Nakagawara, Takako Akiyama, Takayuki Ikeda, Akiyo Yamauchi …

Gene 360(1) 55-64 2005年10月24日
Molecular cloning, expression and chromosomal localization of a novel human REG family gene, REG III.

Koji Nata, Yi Liu, Liqing Xu, Takayuki Ikeda, Takako Akiyama, Naoya Noguchi, Shoko Kawaguchi, Akiyo Yamauchi, Iwao Takahashi, Nausheen J Shervani …

Gene 340(1) 161-70 2004年9月29日
Autoantibodies to REG, a beta-cell regeneration factor, in diabetic patients

Shervani N.J., Takasawa S., Uchigata Y., Akiyama T., Nakagawa K., Noguchi N., Takada H., Takahashi I., Yamauchi A., Ikeda T. …

Eur. J. Clin. Invest. 34 752-758 2004年
Mode of action and QSAR studies of nitrification inhibitors: Effect of trichloromethyl-1,3,5-triazines on ammonia-oxidizing bacteria.

Takahashi I., Ohki S., Murakami M., Takagi S., Sato Y., Vonk J.W., Wakabayashi K.

Journal of Pesticide Science 22 27-32 1997年査読有り筆頭著者
A possible target site of 1,3,5-triazine nitrification inhibitors.

Murakami M., Takagi S., Takahashi I., Tokuyama T., Sato Y., Vonk J.W., Wakabayashi K

Journal of Pesticide Science 20 471-477 1995年

MISC

Impaired beta-cell replication in reterozygous mutant mice of Reg receptor gene

Shin Takasawa, Koji Nata, Iwao Takahashi, Takayuki Ikeda, Naoya Noguchi, Akiyo Yamauchi, Takeo Yoshikawa, Nausheen J. Shervani, Kazusir Sugihara, Masahide Asano …

DIABETES 56(Suppl. 1) A417-A418 2007年6月

共同研究・競争的資金等の研究課題

シンデカン４ノックアウトマウスにおけるインスリン分泌機能の解析

日本学術振興会科学研究費助成事業基盤研究(C) 2018年4月 - 2021年3月

高橋巌, 山田修平