1998
The Fas antigen and Fas-mediated apoptosis in B-cell differentiation
Leukemia and Lymphoma
- ,
- ,
- Volume
- 28
- Number
- 5-6
- First page
- 483
- Last page
- 489
- Language
- English
- Publishing type
- Book review, literature introduction, etc.
- DOI
- 10.3109/10428199809058355
- Publisher
- Informa Healthcare
In the B-cell lineage, Fas, a type 1 membrane protein belonging to the tumor necrosis factor receptor (TNF) family, is expressed on B-cells at a restricted developmental stage and on activated B-cells, but not on naive mature B-cells. Apoptosis mediated by Fas-Fas ligand interactions may be involved in the peripheral elimination of autoreactive B-cells and in the regulation of the immune response through deletion of B-cells activated by foreign antigens, as for the T-cell lineage. Fas-mediated apoptosis associated with B-cell activation is affected by costimulation through other accessory signaling molecules like CD40, whose ligands are on T-cells.
- Link information
- ID information
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- DOI : 10.3109/10428199809058355
- ISSN : 1042-8194
- Pubmed ID : 9613977
- SCOPUS ID : 0031945842