Nov 15, 2005
A tumor-suppressor function for NFATc3 in T-cell lymphomagenesis by murine leukemia virus.
Blood
- Volume
- 106
- Number
- 10
- First page
- 3546
- Last page
- 52
- Language
- English
- Publishing type
Nuclear factor of activated T cell (NFAT) transcription factors play a central role in differentiation, activation, and elimination of lymphocytes. We here report on the finding of provirus integration into the Nfatc3 locus in T-cell lymphomas induced by the murine lymphomagenic retrovirus SL3-3 and show that NFATc3 expression is repressed in these lymphomas. The provirus insertions are positioned close to the Nfatc3 promoter or a putative polyadenylated RNA (polyA) region. Furthermore, we demonstrate that NFATc3-deficient mice infected with SL3-3 develop T-cell lymphomas faster and with higher frequencies than wild-type mice or NFATc2-deficient mice. These results identify NFATc3 as a tumor suppressor for the development of murine T-cell lymphomas induced by the retrovirus SL3-3.
- Link information
- ID information
-
- ISSN : 0006-4971
- Pubmed ID : 16051745
- Pubmed Central ID : PMC1895049