Apr, 2016 - Mar, 2018
Is the iPS marker "TRA-1-60" an indicator of cancer intractability against therapeutics?
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research Grant-in-Aid for Challenging Exploratory Research
- Grant number
- 16K15245
- Japan Grant Number (JGN)
- JP16K15245
- Grant amount
-
- (Total)
- 3,640,000 Japanese Yen
- (Direct funding)
- 2,800,000 Japanese Yen
- (Indirect funding)
- 840,000 Japanese Yen
1. PODXL1-konckout clones were generated from human three different PDAC lines since the TRA-1-60 is the glycosylated form of PODXL1. Consequently, drastic inhibition of liver metastasis in vivo was observed in all PODXL1-KO clone-xenografted mice generated from MiaPaCa-2, AsPC1, Panc-1.
2. PODXL1 revealed to form complex with multiple cytokine receptors and its binding contribute to activate those receptors.
3. PODXL1 was highly expressed at the invasive front and metastatic foci of PDAC cells in patients' tumor tissues.
2. PODXL1 revealed to form complex with multiple cytokine receptors and its binding contribute to activate those receptors.
3. PODXL1 was highly expressed at the invasive front and metastatic foci of PDAC cells in patients' tumor tissues.
- Link information
- ID information
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- Grant number : 16K15245
- Japan Grant Number (JGN) : JP16K15245