Mitaka Toshihiro

J-GLOBAL         Last updated: Nov 8, 2018 at 13:59
 
Avatar
Name
Mitaka Toshihiro
Affiliation
Sapporo Medical University
Job title
Professor

Research Areas

 
 

Academic & Professional Experience

 
Apr 2011
 - 
Today
Full Professor, Department of Tissue Development and Regeneration, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine
 
Sep 2002
 - 
Mar 2011
Full Professor, Department of Pathophysiology, Cancer Research Institute, Sapporo Medical University School of Medicine
 
Jul 1998
 - 
Aug 2002
Associate Professor, Department of Pathology, Cancer Research Institute, Sapporo Medical College
 
1993
 - 
1998
Assistant Professor, Department of Pathology, Cancer Research Institute, Sapporo Medical College
 
Nov 1990
 - 
Sep 1993
Instructor, Department of Pathology, Cancer Research Institute, Sapporo Medical University School of Medicine
 

Education

 
 
 - 
1988
Sapporo Medical University
 
Apr 1978
 - 
Mar 1984
School of Medicine, Sapporo Medical College
 

Awards & Honors

 
2001
The Takeda Techno-Entrepreneurship Award 2001
 

Published Papers

 
Tanimizu N, Kobayashi S, Ichinohe N, Mitaka T
Development (Cambridge, England)   141(23) 4448-4456   Dec 2014   [Refereed]
Tanimizu N, Kaneko K, Itoh T, Ichinohe N, Ishii M, Mizuguchi T, Hirata K, Miyajima A, Mitaka T
Hepatology (Baltimore, Md.)   64(1) 175-188   Jul 2016   [Refereed]
Kikkawa Y, Miwa T, Tanimizu N, Kadoya Y, Ogawa T, Katagiri F, Hozumi K, Nomizu M, Mizuguchi T, Hirata K, Mitaka T
Experimental cell research   328(1) 197-206   Oct 2014   [Refereed]
Okita K, Mizuguchi T, Shigenori O, Ishii M, Nishidate T, Ueki T, Meguro M, Kimura Y, Tanimizu N, Ichinohe N, Torigoe T, Kojima T, Mitaka T, Sato N, Sawada N, Hirata K
Surgery today   46(6) 633-640   Jun 2016   [Refereed]
Tanimizu N, Mitaka T
Organogenesis   10(2) 208-215   Apr 2014   [Refereed]
Tanimizu N, Mitaka T
Hepatology research : the official journal of the Japan Society of Hepatology      Jan 2016   [Refereed]
Tanimizu N, Nishikawa Y, Ichinohe N, Akiyama H, Mitaka T
The Journal of biological chemistry   289(11) 7589-7598   Mar 2014   [Refereed]
Nakamura Y, Mizuguchi T, Tanimizu N, Ichinohe N, Ooe H, Kawamoto M, Meguro M, Hirata K, Mitaka T
Cell transplantation   23(10) 1243-1254   2014   [Refereed]
Tanimizu N, Nakamura Y, Ichinohe N, Mizuguchi T, Hirata K, Mitaka T
Journal of cell science   126(Pt 22) 5239-5246   Nov 2013   [Refereed]
Nakamura Y, Mizuguchi T, Tanimizu N, Ichinohe N, Ooe H, Kawamoto M, Meguro M, Hirata K, Mitaka T
Cell transplantation      Jun 2013   [Refereed]
Ichinohe N, Tanimizu N, Ooe H, Nakamura Y, Mizuguchi T, Kon J, Hirata K, Mitaka T
Hepatology (Baltimore, Md.)   57 1192-1202   Mar 2013   [Refereed]
Tanimizu N, Mitaka T
Tissue barriers   1 e23495   Jan 2013   [Refereed]
Kasuya J, Sudo R, Masuda G, Mitaka T, Ikeda M, Tanishita K
Journal of tissue engineering and regenerative medicine      Oct 2012   [Refereed]
[Tissue morphogenesis of liver epithelial cells].
Tanimizu N, Mitaka T
Seikagaku. The Journal of Japanese Biochemical Society   84 658-665   Aug 2012   [Refereed]
Tanimizu N, Kikkawa Y, Mitaka T, Miyajima A
The Journal of biological chemistry   287 28586-28597   Aug 2012   [Refereed]
Senga K, Mostov KE, Mitaka T, Miyajima A, Tanimizu N
Molecular biology of the cell   23 2845-2855   Aug 2012   [Refereed]
Ooe H, Chen Q, Kon J, Sasaki K, Miyoshi H, Ichinohe N, Tanimizu N, Mitaka T
Journal of cellular physiology   227 2363-2370   Jun 2012   [Refereed]
Kasuya J, Sudo R, Mitaka T, Ikeda M, Tanishita K
Tissue engineering. Part A   18 1045-1056   May 2012   [Refereed]
Shibata T, Mizuguchi T, Nakamura Y, Kawamoto M, Meguro M, Ota S, Hirata K, Ooe H, Mitaka T
World journal of gastroenterology : WJG   18 905-914   Mar 2012   [Refereed]
Kasuya J, Sudo R, Tamogami R, Masuda G, Mitaka T, Ikeda M, Tanishita K
Biomaterials   33 2693-2700   Mar 2012   [Refereed]
Ichinohe N, Kon J, Mitaka T
Methods in molecular biology (Clifton, N.J.)   826 49-58   2012   [Refereed]
Ichinohe N, Kon J, Sasaki K, Nakamura Y, Ooe H, Tanimizu N, Mitaka T
Cell transplantation   21 11-22   2012   [Refereed]
Kasuya J, Sudo R, Mitaka T, Ikeda M, Tanishita K
Tissue engineering. Part A   17 361-370   Feb 2011   [Refereed]
Mitaka T, Ooe H
Drug metabolism reviews   42 472-481   Aug 2010   [Refereed]
Ichinohe N, Nakano T, Mitaka T, Umakoshi Y, Tabata Y
Journal of biomedical materials research. Part A   93 646-655   May 2010   [Refereed]
Kon J, Ichinohe N, Ooe H, Chen Q, Sasaki K, Mitaka T
The American journal of pathology   175 2362-2371   Dec 2009   [Refereed]
Ooe H, Kon J, Oshima H, Mitaka T
Drug metabolism and disposition: the biological fate of chemicals   37 1963-1969   Sep 2009   [Refereed]
Nobuoka T, Mizuguchi T, Oshima H, Shibata T, Kaji S, Nagayama M, Meguro M, Mitaka T, Hirata K
Liver international : official journal of the International Association for the Study of the Liver   29 979-987   Aug 2009   [Refereed]
Kikkawa Y, Sudo R, Kon J, Mizuguchi T, Nomizu M, Hirata K, Mitaka T
Experimental cell research   314 2579-2590   Aug 2008   [Refereed]
Hashimoto W, Sudo R, Fukasawa K, Ikeda M, Mitaka T, Tanishita K
The American journal of pathology   173 494-506   Aug 2008   [Refereed]
Oshima H, Kon J, Ooe H, Hirata K, Mitaka T
Journal of cellular biochemistry   104 68-81   May 2008   [Refereed]
Proliferation of hepatocyte progenitor cells isolated from adult human livers in serum-free medium.
Sasaki K, Kon J, Mizuguchi T, Chen Q, Ooe H, Oshima H, Hirata K, Mitaka T
Cell transplantation   17 1221-1230   2008   [Refereed]
Kawasaki H, Mizuguchi T, Oshima H, Nobuoka T, Shibata T, Kaji S, Kokai Y, Katsuramaki T, Mitaka T, Hirata K
Journal of hepato-biliary-pancreatic surgery   15 403-409   2008   [Refereed]
Kawasaki H, Mizuguchi T, Kikkawa Y, Oshima H, Sasaki Y, Tokino T, Kokai Y, Miyazaki J, Katsuramaki T, Mitaka T, Hirata K
Journal of hepato-biliary-pancreatic surgery   15 310-317   2008   [Refereed]
Kikkawa Y, Sasaki T, Nguyen MT, Nomizu M, Mitaka T, Miner JH
The Journal of biological chemistry   282 14853-14860   May 2007   [Refereed]
Chen Q, Kon J, Ooe H, Sasaki K, Mitaka T
Nature protocols   2 1197-1205   2007   [Refereed]
Ooe H, Kon J, Miyamoto S, Ozone Y, Ninomiya S, Mitaka T
Drug metabolism and disposition: the biological fate of chemicals   34 1667-1671   Oct 2006   [Refereed]
Kon J, Ooe H, Oshima H, Kikkawa Y, Mitaka T
Journal of hepatology   45 90-98   Jul 2006   [Refereed]
Manase K, Endo T, Chida M, Nagasawa K, Honnma H, Yamazaki K, Kitajima Y, Goto T, Kanaya M, Hayashi T, Mitaka T, Saito T
Reproductive biology and endocrinology : RB&E   4 32   Jun 2006   [Refereed]
Nagaya M, Kubota S, Suzuki N, Akashi K, Mitaka T
Hepatology (Baltimore, Md.)   43 1053-1062   May 2006   [Refereed]
Shibata C, Mizuguchi T, Kikkawa Y, Nobuoka T, Oshima H, Kawasaki H, Kawamoto M, Katsuramaki T, Mitaka T, Hirata K
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society   12 78-87   Jan 2006   [Refereed]
Mizuguchi T, Oshima H, Imaizumi H, Kohara H, Kawamoto M, Nobuoka T, Kawasaki H, Harada K, Masuda Y, Kikkawa Y, Mitaka T, Asai Y, Hirata K
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society   13 551-557   Nov 2005   [Refereed]
Sudo R, Mitaka T, Ikeda M, Tanishita K
FASEB journal : official publication of the Federation of American Societies for Experimental Biology   19 1695-1697   Oct 2005   [Refereed]
Miyamoto S, Hirata K, Sugimoto S, Harada K, Mitaka T
Journal of gastroenterology and hepatology   20 865-872   Jun 2005   [Refereed]
Sudo R, Kohara H, Mitaka T, Ikeda M, Tanishita K
Annals of biomedical engineering   33 696-708   May 2005   [Refereed]
Sugimoto S, Harada K, Shiotani T, Ikeda S, Katsura N, Ikai I, Mizuguchi T, Hirata K, Yamaoka Y, Mitaka T
Tissue engineering   11 626-633   Mar 2005   [Refereed]
Mizuguchi T, Mitaka T, Katsuramaki T, Hirata K
Journal of hepato-biliary-pancreatic surgery   12 378-385   2005   [Refereed]
Nakajima-Nagata N, Sakurai T, Mitaka T, Katakai T, Yamato E, Miyazaki J, Tabata Y, Sugai M, Shimizu A
Biochemical and biophysical research communications   318 625-630   Jun 2004   [Refereed]
Harada K, Mitaka T, Miyamoto S, Sugimoto S, Ikeda S, Takeda H, Mochizuki Y, Hirata K
Journal of hepatology   39 716-723   Nov 2003   [Refereed]
Accumulation of Hsp70/Hsc70 molecular chaperone regulator BAG-1 on COPI-coated structures in gastric epithelial cells.
Takamura A, Adachi M, Wada I, Mitaka T, Takayama S, Imai K
International journal of oncology   23 1301-1308   Nov 2003   [Refereed]

Misc

 
Small Hepatocytes in Primary Culture
The Hepatocyte Review      2000
Increased expression of cell adhesion kinase beta in human and rat crescentic glomerulonephritis.
Am J Kidney Dis   39 174-82   2002
Biochem Biophys Res Commun   281(1) 1-5   2001
Int J Exp Pathol   79 393-409   1998
J. Hepatobililiary Pancreat. Surg   9(6) 697-703   2001
Growth and maturation of small hepatocytes.
J Gastroenterol Hepatol   13 70-7   1998
Artif Organs   24 271-7   2000
Restricted expression of cell adhesion kinase-beta in rat tissues.
Am J Pathol   150 267-81   1997

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 1996 - 1997    Investigator(s): Toshihiro MITAKA
A small hepatocyte can clonally proliferate for more than 3 months when the cells are cultured in DMEM supplemented with 10% FBS,10mM nicotinamide, 1mM ascorbic acid 2-phosphate, 10ng/mI EGF and 1% DMSO.The cell divides to form a colony and the nu...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 1997 - 1999    Investigator(s): Koichi HIRATA
A.Sepsis and Cholestasis---Basic findings in the sinusoid and in bile canaliculus---Hepatic dysfunction, as one of unfavorable the pathophysiologic condition in sepsis, is induced by the alterations in both macro- and microcirculatory disturbance ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 1998 - 2000    Investigator(s): Toshihiro MITAKA
We isolated a kind of hepatic progenitor cells, small hepatocytes, from an adult rat liver. A small hepatocyte can clonally proliferate for more than 3 months when the cells are cultured in DMEM supplemented with 10% FBS, 10mM nicotinamide, 1mM as...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2000 - 2001    Investigator(s): Toshihiro MITAKA
Small hepatocytes (SHs), which are known to be hepatic progenitor cells, were isolated from an adult rat liver. We found methods by which SHs could differentiate into mature hepatocytes(MHs) and form three-dimensional structures. SHs in a colony s...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2000 - 2001    Investigator(s): Kazuo TANISHITA
The morphogenesis and movement of bile canaliculi (BC) are not well understood. This is because culture of hepatocytes that maintain polarity of cell membranes and possess highly differentiated functions has never been successful. We found that sm...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2000 - 2001    Investigator(s): Yohichi MOCHIZUKI
Small hepatocytes (SHs), which are known to be hepatic progenitor cells, were isolated from an adult rat liver. We found methods by which SHs could differentiate into mature hepatocytes and form three-dimensional structures. SHs in a colony someti...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2000 - 2002    Investigator(s): Koichi HIRATA
This research program was composed of three components, namely the first is"the establishment extracorporeal hepatic tissue structure", the second is"the study of bile stasis under in vitro condition" and the third is "the treatment of hepatic fai...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2001 - 2004    Investigator(s): Koichi HIRATA
[Background] It is envisaged that hepatocyte transplantation and extracorporeal liver support systems may be a future alternative therapy to orthotopic liver transplantation. Small hepatocytes known as liver hepatocyte stem cells would be consider...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2002 - 2004    Investigator(s): Toshihiro MITAKA
We found three genes, CD44, BRI3, and D6.1A, with much higher expression in small hepatocytes (SHs)than in mature hepatocytes (MHs)and possessing transmembrane domain. Using specific antibody to CD44, BRI3, and D6.1A, we examined the localization ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2002 - 2003    Investigator(s): Iwao IKAI
The aim of this study was to isolate and characterize human hepatic stem/progenitor cells from human liver and to reconstruct the liver tissue.Isolation method of hepatic stem progenitor cells from fetal and adult mise liver was established using ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2003 - 2005    Investigator(s): Koichi HIRATA
(1)It has been suggested that the mostly irregular contractions of bile canalicular net work constituted among the hepatoid structure by cultured small hepatocytes were. This movement was presented as calculated number by the specific-soft utiliza...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2005 - 2007    Investigator(s): Toshihiro MITAKA
We have reported that CD44 is specifically expressed in rat small hepatocytes and that CD44^+ hepatocytes transiently appear in injured rat livers. Using a specific antibody, we sorted CD44^+ cells from galactosamine-treated rat livers and culture...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2005 - 2007    Investigator(s): Yamato KIKKAWA
Laminins are a diverse group of alpha/beta/gamma heterotrimers formed from five alpha, three beta and three gamma chains ; they are major components of all basal laminae (BLs). One laminin chain that has garnered particular interest due to its wid...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2007 - 2009    Investigator(s): Koichi HIRATA
The researches were composed of three kinds of contents as follows : (1) the studies about low localized molucules utilized for the assessments of hepatic function, (2) the regulation on isolation, identification and proliferation of hepatic stem ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2008 - 2010    Investigator(s): Toru MIZUGUCHI
It is very important to perform surgical operation to obtain cell donation for cell transplantation therapy. Conventional hepatectomy has been considered to be difficult to decrease high mobidity with mortlity. A saline-linked electiric cautery wa...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2008 - 2010    Investigator(s): Yamato KIKKAWA
The isolated cells rapidly lose viability and hepatic functions. Therefore, for development of culture systems for primary hepatocytes, effective substrata are required for both hepatocyte adhesion and maintenance of hepatic function. In this stud...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2009 - 2011    Investigator(s): Toshihiro MITAKA
We aimed to develop the methods of producing a large number of small hepatocytes(SHs), hepatic progenitor cells, and to establish the methods of hepatic organoid formation in vitro. In addition, we examined how cells and tissues could be transplan...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2010 - 2012    Investigator(s): Koichi HIRATA
We have achieved the results by the clinical and basic studies.【Study 1】We developed a rat model of acute liver failure after 2/3 partial hepatectomy (PH) for non-alcoholic steatohepatitis (NASH)-related cirrhosis. The mechanism by which HT improv...