2013年2月
Identification of autoantibodies expressed in acquired aplastic anaemia
BRITISH JOURNAL OF HAEMATOLOGY
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 160
- 号
- 3
- 開始ページ
- 359
- 終了ページ
- 362
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/bjh.12116
- 出版者・発行元
- WILEY-BLACKWELL
Acquired aplastic anaemia (aAA) is recognized as an autoimmune disorder; however, the autoantigens and target cells involved remain elusive. Expression of autoantibodies and their target cells were examined using the haematopoietic cell line K562 and bone marrow stromal cell line hTS-5; 43.5% and 21.7% of aAA expressed autoantibody against K562 and hTS-5 cells, respectively. The autoantigens were identified by serological identification of antigens through recombinant cDNA expression cloning. This study indicates that haematopoietic cells are the targets of immune abnormality in aAA. These autoantibodies may be utilized to distinguish patients associated with immune abnormality from bone marrow failure syndrome.
- リンク情報
- ID情報
-
- DOI : 10.1111/bjh.12116
- ISSN : 0007-1048
- PubMed ID : 23116149
- Web of Science ID : WOS:000313746600010