論文

査読有り
2014年10月

Prophylactic and Therapeutic Effects of Acanthopanax senticosus Harms Extract on Murine Collagen-induced Arthritis

PHYTOTHERAPY RESEARCH
  • Yusuke Takahashi
  • ,
  • Maki Tanaka
  • ,
  • Ryosei Murai
  • ,
  • Kageaki Kuribayashi
  • ,
  • Daisuke Kobayashi
  • ,
  • Nozomi Yanagihara
  • ,
  • Naoki Watanabe

28
10
開始ページ
1513
終了ページ
1519
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/ptr.5157
出版者・発行元
WILEY-BLACKWELL

Evidences are accumulating that extract of Acanthopanax senticosus Harms (ASH; syn Eleutherococcus senticosus [Rupr. & Maxim.] Maxim), a shrub native to Northeastern Asia, has antiinflammatory effects. In this study, we examined prophylactic and therapeutic effects of ASH extract (ASHE) on rheumatoid arthritis using collagen-induced arthritis (CIA) mouse model. Acanthopanax senticosus Harms extract was administered before the onset of arthritis in the prophylaxis model. In the therapeutic model, ASHE was administered after the onset of arthritis with or without anti-TNF- antibody. The ASHE treatment showed efficacy before onset of CIA but there was no effect after CIA was established. The ASHE treatment delayed the onset and decreased severity of CIA. In vitro examinations showed that ASHE is an antioxidant and that ASHE suppresses TNF- and interleukin-6 production in human peripheral blood mononuclear cells. The combination therapy with ASHE and anti-TNF- antibody reduced the severity of arthritis compared with anti-TNF- antibody alone. The present study shows that ASHE has prophylactic effect against CIA and support therapeutic effect of anti-TNF- antibody. (c) 2014 The Authors. Phytotherapy Research published by John Wiley & Sons Ltd.

リンク情報
DOI
https://doi.org/10.1002/ptr.5157
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/24797499
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000342798700011&DestApp=WOS_CPL
ID情報
  • DOI : 10.1002/ptr.5157
  • ISSN : 0951-418X
  • eISSN : 1099-1573
  • PubMed ID : 24797499
  • Web of Science ID : WOS:000342798700011

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