論文

査読有り
2017年11月

Gelation Factors of Pectin for Development of a Powder Form of Gel, Dry Jelly, as a Novel Dosage Form

CHEMICAL & PHARMACEUTICAL BULLETIN
  • Yukari Kakino
  • ,
  • Yoshihiro Hishikawa
  • ,
  • Risako Onodera
  • ,
  • Kohei Tahara
  • ,
  • Hirofumi Takeuchi

65
11
開始ページ
1035
終了ページ
1044
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1248/cpb.c17-00447
出版者・発行元
PHARMACEUTICAL SOC JAPAN

Jellies for oral administration are dosage forms that contain water, as stipulated in the Japanese Pharmacopeia, and heat is generally applied to the jellies during the manufacturing process. Therefore, it is difficult to formulate drugs that may be affected adversely by water and/or heat. To solve this problem, we tried to develop a powder form of gel as a novel dosage form (dry jelly: jelly medicine extemporaneously prepared) that is converted to jelly after addition of water at the time of administration. For this purpose, a basic gel formulation consisting of pectin, glucono-delta-lactone, dibasic calcium phosphate hydrate, and sucrose was investigated to evaluate the critical factors affecting gelation phenomena. The gel form was developed by adjusting the amount of each component of the formulation and of water added. Gelation occurred even with hard water containing metal ions (hardness of approximately 304 mg/L), and no changes in gel hardness occurred. The desired gel hardness could be controlled by adjusting the amount of water. The gel hardness changed over time after the addition of water, but this change did not affect the dissolution behavior of drugs formulated in the dry jelly.

リンク情報
DOI
https://doi.org/10.1248/cpb.c17-00447
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29093290
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000414236000007&DestApp=WOS_CPL
ID情報
  • DOI : 10.1248/cpb.c17-00447
  • ISSN : 0009-2363
  • PubMed ID : 29093290
  • Web of Science ID : WOS:000414236000007

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