Papers

International journal
Oct 13, 2020

Efficacy and Safety of the Radiotherapy for Liver Cancer: Assessment of Local Controllability and its Role in Multidisciplinary Therapy.

Cancers
  • Marina Ohkoshi-Yamada
  • ,
  • Kenya Kamimura
  • ,
  • Osamu Shibata
  • ,
  • Shinichi Morita
  • ,
  • Motoki Kaidu
  • ,
  • Toshimichi Nakano
  • ,
  • Katsuya Maruyama
  • ,
  • Atsushi Ota
  • ,
  • Hirotake Saito
  • ,
  • Nobuko Yamana
  • ,
  • Tomoya Oshikane
  • ,
  • Yukiyo Goto
  • ,
  • Natsumi Yoshimura
  • ,
  • Satoshi Tanabe
  • ,
  • Hisashi Nakano
  • ,
  • Madoka Sakai
  • ,
  • Yuto Tanaka
  • ,
  • Yohei Koseki
  • ,
  • Yoshihisa Arao
  • ,
  • Hiroyuki Abe
  • ,
  • Toru Setsu
  • ,
  • Akira Sakamaki
  • ,
  • Takeshi Yokoo
  • ,
  • Hiroteru Kamimura
  • ,
  • Hidefumi Aoyama
  • ,
  • Shuji Terai

Volume
12
Number
10
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.3390/cancers12102955

This study investigated the efficacy and safety of radiotherapy as part of multidisciplinary therapy for advanced hepatocellular carcinoma (HCC). Clinical data of 49 HCC patients treated with radiotherapy were assessed retrospectively. The efficacy of radiotherapy was assessed by progression-free survival, disease control rate, and overall survival. Safety was assessed by symptoms and hematological assay, and changes in hepatic reserve function were determined by Child-Pugh score and albumin-bilirubin (ALBI) score. Forty patients underwent curative radiotherapy, and nine patients with portal vein tumor thrombus (PVTT) underwent palliative radiotherapy as part of multidisciplinary therapy. Local disease control for curative therapy was 80.0% and stereotactic body radiotherapy was 86.7% which was greater than that of conventional radiotherapy (60.0%). Patients with PVTT had a median observation period of 651 days and 75% three-year survival when treated with multitherapy, including radiotherapy for palliative intent, transcatheter arterial chemoembolization, and administration of molecular targeted agents. No adverse events higher than grade 3 and no changes in the Child-Pugh score and ALBI score were seen. Radiotherapy is safe and effective for HCC treatment and can be a part of multidisciplinary therapy.

Link information
DOI
https://doi.org/10.3390/cancers12102955
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33066141
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601963
ID information
  • DOI : 10.3390/cancers12102955
  • Pubmed ID : 33066141
  • Pubmed Central ID : PMC7601963

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