Papers

International journal
Jan 29, 2020

The neurocognitive function change criteria after whole-brain radiation therapy for brain metastasis, in reference to health-related quality of life changes: a prospective observation study.

BMC cancer
  • Toshimichi Nakano
  • ,
  • Hidefumi Aoyama
  • ,
  • Hirotake Saito
  • ,
  • Satoshi Tanabe
  • ,
  • Kensuke Tanaka
  • ,
  • Katsuya Maruyama
  • ,
  • Tomoya Oshikane
  • ,
  • Atsushi Ohta
  • ,
  • Eisuke Abe
  • ,
  • Motoki Kaidu

Volume
20
Number
1
First page
66
Last page
66
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1186/s12885-020-6559-3

BACKGROUND: We sought to construct the optimal neurocognitive function (NCF) change criteria sensitive to health-related quality of life (HR-QOL) in patients who have undergone whole-brain radiation therapy (WBRT) for brain metastasis. METHODS: We categorized the patients by the changes of NCF into groups of improvement versus deterioration if at least one domain showed changes that exceeded the cut-off while other domains remained stable. The remaining patients were categorized as stable, and the patients who showed both significant improvement and deterioration were categorized as 'both.' We examined the clinical meaning of NCF changes using the cut-off values 1.0, 1.5, and 2.0 SD based on the percentage of patients whose HR-QOL changes were ≥ 10 points. RESULTS: Baseline, 4-month and 8-month data were available in 78, 41 (compliance; 85%), and 29 (81%) patients, respectively. At 4 months, improvement/stable/deterioration/both was seen in 15%/12%/41%/32% of the patients when 1.0 SD was used; 19%/22%/37%/22% with 1.5 SD, and 17%/37%/37%/9% with 2.0 SD. The HR-QOL scores on the QLQ-C30 functional scale were significantly worse in the deterioration group versus the others with 1.0 SD (p = 0.013) and 1.5 SD (p = 0.015). With 1.5 SD, the HR-QOL scores on the QLQ-BN20 was significantly better in the improvement group versus the others (p = 0.033). However, when 'both' was included in 'improvement' or 'deterioration,' no significant difference in HR-QOL was detected. CONCLUSIONS: The NCF cut-off of 1.5 SD and the exclusion of 'both' patients from the 'deterioration' and 'improvement' groups best reflects HR-QOL changes.

Link information
DOI
https://doi.org/10.1186/s12885-020-6559-3
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31996182
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988195
ID information
  • DOI : 10.1186/s12885-020-6559-3
  • Pubmed ID : 31996182
  • Pubmed Central ID : PMC6988195

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