Yuya Haga

Profile Information

Affiliation: Graduate School of Pharmaceutical Sciences, Osaka University

Degree: 博士（薬科学）(Mar, 2021, 大阪大学)

Researcher number: 30888863
ORCID iD: https://orcid.org/0000-0003-4148-2256
J-GLOBAL ID: 202001002140858799
researchmap Member ID: R000004196

Research Areas

Research History

Apr, 2021 - Present

Assistant Professor, Graduate School of Pharmaceutical Sciences, Osaka University
Apr, 2018 - Mar, 2021

Japan Society for the Promotion of Science

Education

Apr, 2018 - Mar, 2021

Advanced Pharmaco-science, Graduate School of Pharmaceutical Sciences, Osaka University
Oct, 2018 - Sep, 2019

Department of Biological Regulation, Visiting student, Weizmann Institute of Science
Apr, 2016 - Mar, 2018

Advanced Pharmaco-science, Graduate School of Pharmaceutical Sciences, Osaka University
Apr, 2012 - Mar, 2016

School of Pharmaceutical Sciences, Osaka University

Awards

Papers

Curcumin Is Primarily Distributed in Lung, Spleen and Liver, Metabolized to Glucuronide and Sulfate, and Excreted through Bile and Urine by Using an Amorphous Curcumin Formulation with High Absorbability.

Tomohiro Nakao, Michiko Nakamura, Kazuya Nagano, Mariko Takeda, Haruna Hirai, Hikaru Maekita, Jian-Qing Gao, Hirofumi Tsujino, Makoto Sakata, Masayuki Nishino …

Biological & pharmaceutical bulletin, 48(3) 314-322, 2025
Exploring Nile Red Staining as an Analytical Tool for Surface-Oxidized Microplastics

Wakaba Idehara, Yuya Haga, Hirofumi Tsujino, Yudai Ikuno, Sota Manabe, Mii Hokaku, Haruyasu Asahara, Kazuma Higashisaka, Yasuo Tsutsumi

Environmental Research, 120934-120934, Jan, 2025 Peer-reviewedLead authorCorresponding author
Localization of silica nanoparticles to lysosome causes lysosomal dysfunction in JEG-3 cells

Jundai Kobayashi, Kazuma Higashisaka, Mizuki Muranaka, Yankun Xie, Wakako Okuno, Yuya Haga, Yasuo Tsutsumi

Biochemical and Biophysical Research Communications, 736 150488-150488, Dec, 2024 Peer-reviewed
Treatment of polyethylene microplastics degraded by ultraviolet light irradiation causes lysosome-deregulated cell death

Sota Manabe, Yuya Haga, Hirofumi Tsujino, Yudai Ikuno, Haruyasu Asahara, Kazuma Higashisaka, Yasuo Tsutsumi

Scientific Reports, 14(1), Oct 14, 2024 Peer-reviewedCorresponding author
A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib.

Arturo Simoni-Nieves, Moshit Lindzen, Suvendu Giri, Nitin Gupta, Rishita Chatterjee, Boobash-Raj Selvadurai, Marieke Van Daele, Danielle Love, Yuya Haga, Donatella Romaniello …

Cell reports. Medicine, 5(9) 101703-101703, Sep 17, 2024 Peer-reviewed
Orally Administered Silver Nanoparticles Are Absorbed and Migrate to Testes in Mice

Yuma Saeki, Kazuma Higashisaka, Rina Izutani, Jiwon Seo, Kazuki Miyaji, Yuya Haga, Yasuo Tsutsumi

ACS Nanoscience Au, Aug 29, 2024 Peer-reviewed
Polyethylene, whose surface has been modified by UV irradiation, induces cytotoxicity: A comparison with microplastics found in beaches.

Yudai Ikuno, Hirofumi Tsujino, Yuya Haga, Sota Manabe, Wakaba Idehara, Mii Hokaku, Haruyasu Asahara, Kazuma Higashisaka, Yasuo Tsutsumi

Ecotoxicology and environmental safety, 277 116346-116346, Jun 1, 2024 Peer-reviewed
Coculture with macrophages alters ferroptosis susceptibility of triple-negative cancer cells

Hiroto Konishi, Yuya Haga, Moe Okumura, Hirofumi Tsujino, Kazuma Higashisaka, Yasuo Tsutsumi

Cell Death Discovery, 10(1), Mar 1, 2024 Peer-reviewedLead authorCorresponding author
Valproic acid elevates HIF-1α-mediated CGB expression and suppresses glucose uptake in BeWo cells.

Go Kitahara, Kazuma Higashisaka, Yurina Nakamoto, Rena Yamamoto, Wakako Okuno, Momoe Serizawa, Yuji Sakahashi, Hirofumi Tsujino, Yuya Haga, Yasuo Tsutsumi

The Journal of toxicological sciences, 49(2) 69-77, 2024 Peer-reviewed
L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab

Ilaria Marrocco, Suvendu Giri, Arturo Simoni-Nieves, Nitin Gupta, Anna Rudnitsky, Yuya Haga, Donatella Romaniello, Arunachalam Sekar, Mirie Zerbib, Roni Oren …

Cell Reports Medicine, 101142-101142, Aug, 2023 Peer-reviewed
Evidence-Based Prediction of Cellular Toxicity for Amorphous Silica Nanoparticles

Martin, Reiko Watanabe, Kosuke Hashimoto, Kazuma Higashisaka, Yuya Haga, Yasuo Tsutsumi, Kenji Mizuguchi

ACS Nano, May 30, 2023 Peer-reviewed
Impact of Degradation of Polyethylene Particles on Their Cytotoxicity

Yudai Ikuno, Hirofumi Tsujino, Yuya Haga, Haruyasu Asahara, Kazuma Higashisaka, Yasuo Tsutsumi

Microplastics, 2(2) 192-201, May 22, 2023 Peer-reviewed
Fluorouracil exacerbates alpha-crystallin B chain-mediated cell migration in triple-negative breast cancer cell lines.

Lili Yang, Yuya Haga, Akihide Nishimura, Yuki Tsujii, Suzuno Tanahashi, Hirofumi Tsujino, Kazuma Higashisaka, Yasuo Tsutsumi

Scientific reports, 13(1) 4010-4010, Mar 10, 2023 Peer-reviewed
Silver Nanoparticles Suppress Retinoic Acid-Induced Neuronal Differentiation in Human-Derived Neuroblastoma SH-SY5Y Cells

Shintaro Yamaguchi, Ryo Isaka, Yuji Sakahashi, Hirofumi Tsujino, Yuya Haga, Kazuma Higashisaka, Yasuo Tsutsumi

ACS Applied Nano Materials, 5(12) 19025-19034, Dec 23, 2022 Peer-reviewed
Osimertinib-tolerant lung cancer cells are susceptible to ferroptosis.

Hiroto Konishi, Yuya Haga, Ying Lin, Hirofumi Tsujino, Kazuma Higashisaka, Yasuo Tsutsumi

Biochemical and biophysical research communications, 641 116-122, Dec 10, 2022 Peer-reviewed
Alpha-crystallin B chains enhance cell migration in basal-like 2 triple-negative breast cancer cells

L. Yang, K. Higashisaka, Y. Haga, H. Tsujino, K. Nagano, Y. Tsutsumi

PHARMAZIE, 77(2), Feb, 2022 Peer-reviewed
Subvisible Particles Derived by Dropping Stress Enhance Anti-PEG Antibody Production and Clearance of PEGylated Proteins in Mice.

Takaki Nakajima, Kazuya Nagano, Yuka Fukuda, Yu Ishima, Hiroko Shibata, Ryo Isaka, Tian-Qi Zhang, Yuya Haga, Kazuma Higashisaka, Hirofumi Tsujino …

Journal of pharmaceutical sciences, 111(5) 1363-1369, Jan 31, 2022 Peer-reviewed
Alpha-crystallin B chains in trastuzumab-resistant breast cancer cells promote endothelial cell tube formation through activating mTOR.

Lili Yang, Kazuma Higashisaka, Masafumi Shimoda, Yuya Haga, Naoki Sekine, Hirofumi Tsujino, Kazuya Nagano, Kenzo Shimazu, Yasuo Tsutsumi

Biochemical and biophysical research communications, 588 175-181, Jan 15, 2022 Peer-reviewed
Silver nanoparticles suppress forskolin-induced syncytialization in BeWo cells

Sakahashi, Y., Higashisaka, K., Isaka, R., Izutani, R., Seo, J., Furuta, A., Yamaki-Ushijima, A., Tsujino, H., Haga, Y., Nakashima, A. …

Nanotoxicology, 16(9-10), 2022 Peer-reviewed
Amorphas Silica Nanoparticles Decrease Human Chorionic Gonadotropin β Expression During Syncytialization of BeWo Cell

Yuji Sakahashi, Rena Yamamoto, Go Kitahara, Rina Izutani, Hirofumi Tsujino, Yuya Haga, Kazuma Higashisaka, Yasuo Tsutsumi

BPB Reports, 5(6) 154-158, 2022 Peer-reviewed

Misc.

化学物質の胎盤毒性解析とその評価手法の開発—Placental toxicity of chemicals and development of its evaluation methods

東阪和馬, 芳賀優弥, 堤康央

細胞, 56(3) 184-187, Mar, 2024
Mechanisms of Cell Toxicity Caused by Degraded Microplastics

Haga Yuya, Manabe Sota, Tsujino Hirofumi, Asahara Haruyasu, Higashisaka Kazuma, Tsutsumi Yasuo

YAKUGAKU ZASSHI, 144(2) 177-181, Feb 1, 2024 Lead author
Preparation of Degraded Microplastics That Imitate Surface Properties in the Environment

Tsujino Hirofumi, Ikuno Yudai, Haga Yuya, Asahara Haruyasu, Higashisaka Kazuma, Tsutsumi Yasuo

YAKUGAKU ZASSHI, 144(2) 171-175, Feb 1, 2024
香粧品ナノマテリアルの安全性評価 : 獲得免疫系を介したハザード解析とその機序解明—Nano-safety science and Nano-safety design research of nanomaterial in cosmetic products—化粧品の安全性評価

東阪和馬, 芳賀優弥, 堤康央

Fragrance journal : research & development for cosmetics, toiletries & allied industries = フレグランスジャーナル : 香粧品科学研究開発専門誌, 51(7) 25-29, Jul, 2023
Reversible Drug Resistance Mechanisms in Non-small Cell Lung Cancer

Haga Yuya

YAKUGAKU ZASSHI, 142(12) 1321-1326, Dec 1, 2022 Lead author
微粒子曝露と脆弱な世代への健康影響 : 胎盤毒性/動態解析を例に—Health effects of fine particle exposure on vulnerable generations

東阪和馬, 芳賀優弥, 辻野博文, 堤康央

Bio clinica = バイオクリニカ, 37(1) 61-65, Jan, 2022
機能性サイトカインの医薬への展開とDDSへの応用—Development of functional cytokine for therapy and application for DDS—第1土曜特集構造生命科学による創薬への挑戦 ; タンパク質工学から創薬へ

芳賀優弥, 東阪和馬, 堤康央

医学のあゆみ, 278(6) 602-607, Aug 7, 2021
非小細胞肺がんにおけるEGFRチロシンキナーゼ阻害剤の耐性化機構の解明に向けた検討

林穎, 東阪和馬, 新谷拓也, 花室紗知代, 芳賀優弥, 前田真一郎, 長野一也, 藤尾慈, 堤康央

日本薬学会年会要旨集, 138年会(4) 65-65, Mar, 2018
ホルモン受容体関連蛋白質に着目した、肺がんにおけるEGFRチロシンキナーゼ阻害剤の耐性化機構の解明

花室紗知代, 東阪和馬, 林穎, 新谷拓也, 芳賀優弥, 前田真一郎, 長野一也, 藤尾慈, 堤康央

日本薬学会年会要旨集, 138年会(4) 194-194, Mar, 2018
抗体の親和性向上による生体影響の評価に向けた基礎的検討

竹谷苑子, 長野一也, 森宣瑛, 永野貴士, 向井美穂, 大須賀絵理, 芳賀優弥, 井阪亮, 鎌田春彦, 角田慎一 …

日本薬学会年会要旨集, 136年会(3) 144-144, Mar, 2016

Books and Other Publications

機能性サイトカインの医薬への展開とDDSへの応用

芳賀優弥, 東阪和馬, 堤康央

医学のあゆみ, 2021

Presentations

Exploring the toxicity mechanisms of various microplastics

芳賀優弥

日本薬学会年会要旨集(Web), 2024
The effect of silver nanoparticles on pregnancy via male parents

佐伯悠真, 東阪和馬, 東阪和馬, 東阪和馬, 泉谷里奈, SEO Jiwon, 宮地一輝, 芳賀優弥, 芳賀優弥, 堤康央, 堤康央, 堤康央, 堤康央

日本薬学会年会要旨集(Web), 2024
Preparation of fluorescent nanoplastics for kinetic analysis

HOKAKU Mii, HAGA Yuya, TSUJINO Hirofumi, IDEHARA Wakaba, MANABE Sota, TANAKA Kosuke, HIGASHISAKA Kazuma, TSUTSUMI Yasuo

Annual Meeting of the Japanese Society of Toxicology, 2024, The Japanese Society of Toxicology
Investigation into the intracellular dynamics of micro- and nanoplastics

IDEHARA Wakaba, HAGA Yuya, TSUJINO Hirofumi, MANABE Sota, HOKAKU Mii, IKUNO Yudai, HIGASHISAKA Kazuma, TSUTSUMI Yasuo

Annual Meeting of the Japanese Society of Toxicology, 2024, The Japanese Society of Toxicology
Elucidation of the function of amino acid transporter SLC6A19 during placental syncytialization process

SERIZAWA Momoe, HIGASHISAKA Kazuma, NAKAMOTO Yurina, YAMAMOTO Rena, HAGA Yuya, TSUTSUMI Yasuo

Annual Meeting of the Japanese Society of Toxicology, 2024, The Japanese Society of Toxicology
Valproic acid decreases the expression level of placental tryptophan transporter through HDAC inhibition

HIGASHISAKA Kazuma, NAKAMOTO Yurina, YAMAMOTO Rena, SERIZAWA Momoe, HAGA Yuya, TSUTSUMI Yasuo

Annual Meeting of the Japanese Society of Toxicology, 2024, The Japanese Society of Toxicology
Effects of Fetotoxic Chemicals on the BeWo Cell Syncytialization Process

OKUNO Wakako, HIGASHISAKA Kazuma, KOBAYASHI Jundai, XIE Yankun, MURANAKA Mizuki, HAGA Yuya, TSUTSUMI Yasuo

Annual Meeting of the Japanese Society of Toxicology, 2024, The Japanese Society of Toxicology
Evaluation of Toxicity of Silver Nanoparticle on Male Reproductive Capacity

SAEKI Yuma, HIGASHISAKA Kazuma, IZUTANI Rina, SEO Jiwon, MIYAJI Kazuki, HAGA Yuya, TSUTSUMI Yasuo

Annual Meeting of the Japanese Society of Toxicology, 2024, The Japanese Society of Toxicology
Benzo[a]pyrene and benzo[a]pyrene diol epoxide induce cellular senescence in breast cancer cells

KITAMOTO Natsuko, HAGA Yuya, TSUJII Yuki, HIGASHISAKA Kazuma, TSUTSUMI Yasuo

Annual Meeting of the Japanese Society of Toxicology, 2024, The Japanese Society of Toxicology
Investigation of cytotoxic mechanisms of polyvinyl chloride microplastics

HAGA Yuya, MANABE Sota, TSUJINO Hirofumi, HIGASHISAKA Kazuma, TSUTSUMI Yasuo

Annual Meeting of the Japanese Society of Toxicology, 2024, The Japanese Society of Toxicology
Silver nanoparticles suppress forskolin-induced syncytialization in BeWo cells

Yuji Sakahashi, Kazuma Higashisaka, Ryo Isaka, Rina Izutani, Jiwon Seo, Atsushi Furuta, Akemi Yamaki-Ushijima, Hirofumi Tsujino, Yuya Haga, Akitoshi Nakashima, Yasuo Tsutsumi

Nanotoxicology, Jan 3, 2023, Informa UK Limited
Survival mechanisms of chemotherapy tolerant cancer cells through immune escape

棚橋涼乃, 芳賀優弥, 西村哲秀, ZHOU Mo, 辻野博文, 辻野博文, 東阪和馬, 東阪和馬, 堤康央, 堤康央, 堤康央

日本薬剤学会年会講演要旨集(CD-ROM), 2023
The co-culture of triple-negative breast cancer cells and macrophages enhances ferroptosis susceptibility.

芳賀優弥, 小西弘登, 辻野博文, 辻野博文, 東阪和馬, 東阪和馬, 堤康央, 堤康央, 堤康央

がんと代謝研究会プログラム&抄録集, 2023
The effect of interaction of macrophages and triple-negative breast cancer cells on ferroptosis induction

芳賀優弥, 小西弘登, 辻野博文, 辻野博文, 東阪和馬, 東阪和馬, 堤康央, 堤康央, 堤康央

日本薬剤学会年会講演要旨集(CD-ROM), 2023
非晶質ナノシリカ曝露による胎盤炎症応答の解析

山本怜奈, 東阪和馬, 東阪和馬, 北原剛, 仲本有里菜, 坂橋優治, 辻野博文, 辻野博文, 芳賀優弥, 堤康央, 堤康央, 堤康央

日本食品化学学会総会・学術大会講演要旨集, 2023
食品関連製品に含まれるナノマテリアルの神経細胞分化への影響解析

東阪和馬, 東阪和馬, 辻野博文, 辻野博文, 芳賀優弥, 堤康央, 堤康央, 堤康央

日本食品化学学会総会・学術大会講演要旨集, 2023
ナノマテリアル曝露が妊娠準備から着床期に及ぼす影響評価

泉谷里奈, 東阪和馬, 東阪和馬, 坂橋優治, SEO Jiwon, 宮地一輝, 辻野博文, 辻野博文, 芳賀優弥, 堤康央, 堤康央, 堤康央

日本食品化学学会総会・学術大会講演要旨集, 2023
Investigation of reversibility of drug tolerant non-small cell lung cancer cells.

西村哲秀, ZHOU Mo, 芳賀優弥

日本がん分子標的治療学会学術集会プログラム・抄録集, 2023
Cell cycle dynamics analysis of drug-tolerant persister cells in non-small cell lung cancer.

ZHOU Mo, 西村哲秀, 芳賀優弥

日本がん分子標的治療学会学術集会プログラム・抄録集, 2023
The interaction of macrophages and cancer cells alters ferroptosis in triple-negative breast cancer cells.

芳賀優弥

日本がん分子標的治療学会学術集会プログラム・抄録集, 2023

Teaching Experience

Professional Memberships

Research Projects

生体外化学物質による老化毒性ががん悪性転化に及ぼす影響解析

科学研究費助成事業若手研究, 若手研究, 日本学術振興会, Apr, 2022 - Mar, 2025

芳賀優弥
食品含有・残留化学物質のがん悪性転化毒性評価法の開発

食品の安全確保推進研究事業, 厚生労働省, 2022 - 2025
薬剤耐性過程に腫瘍細胞が示す分子発現変動および細胞特性変化の経時的理解

科学研究費助成事業研究活動スタート支援, 研究活動スタート支援, 日本学術振興会, Aug, 2021 - Mar, 2023

芳賀優弥
老化細胞様薬剤抵抗性細胞の分子機序解明と治療標的への展開

研究助成金, 薬学研究奨励財団, Apr, 2022
網羅的な変動蛋白質解析による、難治性乳がんＴＮＢＣの薬効予測バイオマーカーの同定

科学研究費助成事業特別研究員奨励費, 特別研究員奨励費, 日本学術振興会, Apr, 2018 - Mar, 2021

芳賀優弥

Profile Information

Research Areas

Research History

Education

Awards

Papers

Misc.

Books and Other Publications

Presentations

Teaching Experience

Professional Memberships

Research Projects

Menu

Coauthors