芳賀優弥 (Yuya Haga) - 論文

Curcumin Is Primarily Distributed in Lung, Spleen and Liver, Metabolized to Glucuronide and Sulfate, and Excreted through Bile and Urine by Using an Amorphous Curcumin Formulation with High Absorbability.

Tomohiro Nakao, Michiko Nakamura, Kazuya Nagano, Mariko Takeda, Haruna Hirai, Hikaru Maekita, Jian-Qing Gao, Hirofumi Tsujino, Makoto Sakata, Masayuki Nishino …

Biological & pharmaceutical bulletin 48(3) 314-322 2025年

Exploring Nile Red Staining as an Analytical Tool for Surface-Oxidized Microplastics

Wakaba Idehara, Yuya Haga, Hirofumi Tsujino, Yudai Ikuno, Sota Manabe, Mii Hokaku, Haruyasu Asahara, Kazuma Higashisaka, Yasuo Tsutsumi

Environmental Research 120934-120934 2025年1月査読有り筆頭著者責任著者

Localization of silica nanoparticles to lysosome causes lysosomal dysfunction in JEG-3 cells

Jundai Kobayashi, Kazuma Higashisaka, Mizuki Muranaka, Yankun Xie, Wakako Okuno, Yuya Haga, Yasuo Tsutsumi

Biochemical and Biophysical Research Communications 736 150488-150488 2024年12月査読有り

Treatment of polyethylene microplastics degraded by ultraviolet light irradiation causes lysosome-deregulated cell death

Sota Manabe, Yuya Haga, Hirofumi Tsujino, Yudai Ikuno, Haruyasu Asahara, Kazuma Higashisaka, Yasuo Tsutsumi

Scientific Reports 14(1) 2024年10月14日査読有り責任著者

A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib.

Arturo Simoni-Nieves, Moshit Lindzen, Suvendu Giri, Nitin Gupta, Rishita Chatterjee, Boobash-Raj Selvadurai, Marieke Van Daele, Danielle Love, Yuya Haga, Donatella Romaniello …

Cell reports. Medicine 5(9) 101703-101703 2024年9月17日査読有り

Orally Administered Silver Nanoparticles Are Absorbed and Migrate to Testes in Mice

Yuma Saeki, Kazuma Higashisaka, Rina Izutani, Jiwon Seo, Kazuki Miyaji, Yuya Haga, Yasuo Tsutsumi

ACS Nanoscience Au 2024年8月29日査読有り

Polyethylene, whose surface has been modified by UV irradiation, induces cytotoxicity: A comparison with microplastics found in beaches.

Yudai Ikuno, Hirofumi Tsujino, Yuya Haga, Sota Manabe, Wakaba Idehara, Mii Hokaku, Haruyasu Asahara, Kazuma Higashisaka, Yasuo Tsutsumi

Ecotoxicology and environmental safety 277 116346-116346 2024年6月1日査読有り

Coculture with macrophages alters ferroptosis susceptibility of triple-negative cancer cells

Hiroto Konishi, Yuya Haga, Moe Okumura, Hirofumi Tsujino, Kazuma Higashisaka, Yasuo Tsutsumi

Cell Death Discovery 10(1) 2024年3月1日査読有り筆頭著者責任著者

Valproic acid elevates HIF-1α-mediated CGB expression and suppresses glucose uptake in BeWo cells.

Go Kitahara, Kazuma Higashisaka, Yurina Nakamoto, Rena Yamamoto, Wakako Okuno, Momoe Serizawa, Yuji Sakahashi, Hirofumi Tsujino, Yuya Haga, Yasuo Tsutsumi

The Journal of toxicological sciences 49(2) 69-77 2024年査読有り

L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab

Ilaria Marrocco, Suvendu Giri, Arturo Simoni-Nieves, Nitin Gupta, Anna Rudnitsky, Yuya Haga, Donatella Romaniello, Arunachalam Sekar, Mirie Zerbib, Roni Oren …

Cell Reports Medicine 101142-101142 2023年8月査読有り

Evidence-Based Prediction of Cellular Toxicity for Amorphous Silica Nanoparticles

Martin, Reiko Watanabe, Kosuke Hashimoto, Kazuma Higashisaka, Yuya Haga, Yasuo Tsutsumi, Kenji Mizuguchi

ACS Nano 2023年5月30日査読有り

Impact of Degradation of Polyethylene Particles on Their Cytotoxicity

Yudai Ikuno, Hirofumi Tsujino, Yuya Haga, Haruyasu Asahara, Kazuma Higashisaka, Yasuo Tsutsumi

Microplastics 2(2) 192-201 2023年5月22日査読有り

Fluorouracil exacerbates alpha-crystallin B chain-mediated cell migration in triple-negative breast cancer cell lines.

Lili Yang, Yuya Haga, Akihide Nishimura, Yuki Tsujii, Suzuno Tanahashi, Hirofumi Tsujino, Kazuma Higashisaka, Yasuo Tsutsumi

Scientific reports 13(1) 4010-4010 2023年3月10日査読有り

Silver Nanoparticles Suppress Retinoic Acid-Induced Neuronal Differentiation in Human-Derived Neuroblastoma SH-SY5Y Cells

Shintaro Yamaguchi, Ryo Isaka, Yuji Sakahashi, Hirofumi Tsujino, Yuya Haga, Kazuma Higashisaka, Yasuo Tsutsumi

ACS Applied Nano Materials 5(12) 19025-19034 2022年12月23日査読有り

Osimertinib-tolerant lung cancer cells are susceptible to ferroptosis.

Hiroto Konishi, Yuya Haga, Ying Lin, Hirofumi Tsujino, Kazuma Higashisaka, Yasuo Tsutsumi

Biochemical and biophysical research communications 641 116-122 2022年12月10日査読有り

Alpha-crystallin B chains enhance cell migration in basal-like 2 triple-negative breast cancer cells

L. Yang, K. Higashisaka, Y. Haga, H. Tsujino, K. Nagano, Y. Tsutsumi

PHARMAZIE 77(2) 2022年2月査読有り

Subvisible Particles Derived by Dropping Stress Enhance Anti-PEG Antibody Production and Clearance of PEGylated Proteins in Mice.

Takaki Nakajima, Kazuya Nagano, Yuka Fukuda, Yu Ishima, Hiroko Shibata, Ryo Isaka, Tian-Qi Zhang, Yuya Haga, Kazuma Higashisaka, Hirofumi Tsujino …

Journal of pharmaceutical sciences 111(5) 1363-1369 2022年1月31日査読有り

Alpha-crystallin B chains in trastuzumab-resistant breast cancer cells promote endothelial cell tube formation through activating mTOR.

Lili Yang, Kazuma Higashisaka, Masafumi Shimoda, Yuya Haga, Naoki Sekine, Hirofumi Tsujino, Kazuya Nagano, Kenzo Shimazu, Yasuo Tsutsumi

Biochemical and biophysical research communications 588 175-181 2022年1月15日査読有り

Silver nanoparticles suppress forskolin-induced syncytialization in BeWo cells

Sakahashi, Y., Higashisaka, K., Isaka, R., Izutani, R., Seo, J., Furuta, A., Yamaki-Ushijima, A., Tsujino, H., Haga, Y., Nakashima, A. …

Nanotoxicology 16(9-10) 2022年査読有り

Amorphas Silica Nanoparticles Decrease Human Chorionic Gonadotropin β Expression During Syncytialization of BeWo Cell

Yuji Sakahashi, Rena Yamamoto, Go Kitahara, Rina Izutani, Hirofumi Tsujino, Yuya Haga, Kazuma Higashisaka, Yasuo Tsutsumi

BPB Reports 5(6) 154-158 2022年査読有り

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