論文

査読有り 国際誌
2018年2月

Connective Tissue Growth Factor Neutralization Aggravates the Psoriasis Skin Lesion: The Analysis of Psoriasis Model Mice and Patients.

Annals of dermatology
  • Kunihiro Hayakawa
  • Keigo Ikeda
  • Maki Fujishiro
  • Yuko Yoshida
  • Takuya Hirai
  • Hiroshi Tsushima
  • Tomoko Miyashita
  • Shinji Morimoto
  • Yasushi Suga
  • Kenji Takamori
  • Hideoki Ogawa
  • Iwao Sekigawa
  • 全て表示

30
1
開始ページ
47
終了ページ
53
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.5021/ad.2018.30.1.47

Background: Connective tissue growth factor (CTGF) is a multifunctional cellular protein and playing a role as a central mediator in tissue remodeling and fibrosis. The physiological function of CTGF in psoriasis is unknown. Objective: The purpose of this study was to investigate the function of CTGF in psoriasis using the established imiquimod (IMQ)-induced psoriasis murine model and psoriasis patients. Methods: Anti-CTGF monoclonal antibody was applied to IMQ induced psoriasis mice and those skin were clinically, pathologically and immunologically analyzed. Additionally, CTGF expression was analyzes using skin samples and plasma from psoriasis patients. Results: CTGF expression was observed in the dermis from both IMQ-induced psoriatic mice and psoriasis patients. CTGF inhibition using an anti-CTGF antibody slightly worsened IMQ-induced dermatitis. In addition, the increase of CTGF showed tendency to suppress the psoriatic dermatitis through inhibition of suprabasal cells proliferation and macrophage infiltration in the skin. CTGF was also detected significantly higher in plasma from psoriasis patients comparing with healthy control. Conclusion: Our findings suggest that CTGF could contribute to the healing rather than the worsening of psoriasis skin lesions.

リンク情報
DOI
https://doi.org/10.5021/ad.2018.30.1.47
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29386832
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762476
ID情報
  • DOI : 10.5021/ad.2018.30.1.47
  • PubMed ID : 29386832
  • PubMed Central 記事ID : PMC5762476

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