神矢佑輔 (Yusuke Kamiya) - マイポータル

基本情報

所属: 琉球大学病院薬剤部
: 昭和薬科大学薬学部

学位: 博士（薬学）(2017年3月)

J-GLOBAL ID: 202001020113118846
researchmap会員ID: B000382229

研究分野

ライフサイエンス / 医療薬学 /

論文

Low cerebrospinal fluid-to-plasma ratios of orally administered lenalidomide mediated by its low cell membrane permeability in patients with hematologic malignancies.

Daisuke Ogiya, Norie Murayama, Yusuke Kamiya, Rie Saito, Sawako Shiraiwa, Rikio Suzuki, Shinichiro Machida, Kei Tazume, Kiyoshi Ando, Hiroshi Yamazaki

Annals of hematology 101(9) 2013-2019 2022年9月
Correction to "An Updated In Silico Prediction Method for Volumes of Systemic Circulation of 323 Disparate Chemicals for Use in Physiologically Based Pharmacokinetic Models to Estimate Plasma and Tissue Concentrations after Oral Doses in Rats".

Yusuke Kamiya, Kentaro Handa, Tomonori Miura, Junya Ohori, Makiko Shimizu, Masato Kitajima, Fumiaki Shono, Kimito Funatsu, Hiroshi Yamazaki

Chemical research in toxicology 35(8) 1433-1433 2022年8月15日
Trivariate Linear Regression and Machine Learning Prediction of Possible Roles of Efflux Transporters in Estimated Intestinal Permeability Values of 301 Disparate Chemicals.

Makiko Shimizu, Riku Hayasaka, Yusuke Kamiya, Hiroshi Yamazaki

Biological & pharmaceutical bulletin 45(8) 1142-1157 2022年8月1日
Machine Learning Prediction of the Three Main Input Parameters of a Simplified Physiologically Based Pharmacokinetic Model Subsequently Used to Generate Time-Dependent Plasma Concentration Data in Humans after Oral Doses of 212 Disparate Chemicals.

Yusuke Kamiya, Kentaro Handa, Tomonori Miura, Junya Ohori, Airi Kato, Makiko Shimizu, Masato Kitajima, Hiroshi Yamazaki

Biological & pharmaceutical bulletin 45(1) 124-128 2022年1月1日
Plasma Concentration Profiles for Hepatotoxic Pyrrolizidine Alkaloid Senkirkine in Humans Extrapolated from Rat Data Sets Using a Simplified Physiologically Based Pharmacokinetic Model.

Yusuke Kamiya, Tomonori Miura, Airi Kato, Norie Murayama, Makiko Shimizu, Hiroshi Yamazaki

Drug metabolism and bioanalysis letters 15(1) 64-69 2022年
An Updated In Silico Prediction Method for Volumes of Systemic Circulation of 323 Disparate Chemicals for Use in Physiologically Based Pharmacokinetic Models to Estimate Plasma and Tissue Concentrations after Oral Doses in Rats.

Yusuke Kamiya, Kentaro Handa, Tomonori Miura, Junya Ohori, Makiko Shimizu, Masato Kitajima, Fumiaki Shono, Kimito Funatsu, Hiroshi Yamazaki

Chemical research in toxicology 34(10) 2180-2183 2021年10月18日
Prediction of permeability across intestinal cell monolayers for 219 disparate chemicals using in vitro experimental coefficients in a pH gradient system and in silico analyses by trivariate linear regressions and machine learning

Yusuke Kamiya, Asuka Omura, Riku Hayasaka, Rie Saito, Izumi Sano, Kentaro Handa, Junya Ohori, Masato Kitajima, Fumiaki Shono, Kimito Funatsu, Hiroshi Yamazaki

Biochemical Pharmacology 192 2021年10月
Hepatotoxicological potential of P-toluic acid in humanised-liver mice investigated using simplified physiologically based pharmacokinetic models.

Tomonori Miura, Yusuke Kamiya, Shotaro Uehara, Norie Murayama, Makiko Shimizu, Hiroshi Suemizu, Hiroshi Yamazaki

Xenobiotica; the fate of foreign compounds in biological systems 51(6) 636-642 2021年6月
In Silico Prediction of Input Parameters for Simplified Physiologically Based Pharmacokinetic Models for Estimating Plasma, Liver, and Kidney Exposures in Rats after Oral Doses of 246 Disparate Chemicals

Yusuke Kamiya, Kentaro Handa, Tomonori Miura, Mayu Yanagi, Kazuki Shigeta, Shiori Hina, Makiko Shimizu, Masato Kitajima, Fumiaki Shono, Kimito Funatsu, Hiroshi Yamazaki

Chemical Research in Toxicology 34(2) 507-513 2021年2月15日
Metabolic profiles for the pyrrolizidine alkaloid neopetasitenine and its metabolite petasitenine in humans extrapolated from rat in vivo and in vitro data sets using a simplified physiologically based pharmacokinetic model

Mayu Yanagi, Yusuke Kamiya, Norie Murayama, Kaito Banju, Makiko Shimizu, Hiroshi Yamazaki

Journal of Toxicological Sciences 46(9) 391-399 2021年
Different Hepatic Concentrations of Bromobenzene, 1,2-Dibromobenzene, and 1,4-Dibromobenzene in Humanized-Liver Mice Predicted Using Simplified Physiologically Based Pharmacokinetic Models as Putative Markers of Toxicological Potential.

Tomonori Miura, Makiko Shimizu, Shotaro Uehara, Manae Yoshizawa, Ayane Nakano, Mayu Yanagi, Yusuke Kamiya, Norie Murayama, Hiroshi Suemizu, Hiroshi Yamazaki

Chemical research in toxicology 33(12) 3048-3053 2020年12月21日
Metabolic Profiles of Tetrabromobisphenol A in Humans Extrapolated from Humanized-Liver Mouse Data Using a Simplified Physiologically Based Pharmacokinetic Model.

Tomonori Miura, Shotaro Uehara, Kazuki Shigeta, Manae Yoshizawa, Yusuke Kamiya, Norie Murayama, Makiko Shimizu, Hiroshi Suemizu, Hiroshi Yamazaki

Chemical research in toxicology 34(2) 522-528 2020年11月16日
Increased plasma concentrations of an antidyslipidemic drug pemafibrate co-administered with rifampicin or cyclosporine A in cynomolgus monkeys genotyped for the organic anion transporting polypeptide 1B1.

Shin-Ichiro Ogawa, Makiko Shimizu, Yusuke Kamiya, Shotaro Uehara, Hiroshi Suemizu, Hiroshi Yamazaki

Drug metabolism and pharmacokinetics 35(4) 354-360 2020年8月査読有り
Physiologically Based Pharmacokinetic Models Predicting Renal and Hepatic Concentrations of Industrial Chemicals after Virtual Oral Doses in Rats.

Yusuke Kamiya, Shohei Otsuka, Tomonori Miura, Manae Yoshizawa, Ayane Nakano, Miyu Iwasaki, Yui Kobayashi, Makiko Shimizu, Masato Kitajima, Fumiaki Shono, Kimito Funatsu, Hiroshi Yamazaki

Chemical research in toxicology 33(7) 1736-1751 2020年7月20日査読有り
Metabolic profiles of coumarin in human plasma extrapolated from a rat data set with a simplified physiologically based pharmacokinetic model.

Tomonori Miura, Yusuke Kamiya, Shiori Hina, Yui Kobayashi, Norie Murayama, Makiko Shimizu, Hiroshi Yamazaki

The Journal of toxicological sciences 45(11) 695-700 2020年
Plasma, liver, and kidney exposures in rats after oral doses of industrial chemicals predicted using physiologically based pharmacokinetic models: A case study of perﬂuorooctane sulfonic acid.

Yusuke Kamiya, Mayu Yanagi, Shiori Hina, Kazuki Shigeta, Tomonori Miura, Hiroshi Yamazaki

The Journal of toxicological sciences 45(12) 763-767 2020年
Determination and prediction of permeability across intestinal epithelial cell monolayer of a diverse range of industrial chemicals/drugs for estimation of oral absorption as a putative marker of hepatotoxicity.

Yusuke Kamiya, Hiroka Takaku, Rio Yamada, Chisato Akase, Yuto Abe, Yuko Sekiguchi, Norie Murayama, Makiko Shimizu, Masato Kitajima, Fumiaki Shono, Kimito Funatsu, Hiroshi Yamazaki

Toxicology reports 7 149-154 2020年査読有り
Adult and infant pharmacokinetic profiling of dihydrocodeine using physiologically based pharmacokinetic modeling.

Miki Ota, Makiko Shimizu, Yusuke Kamiya, Chie Emoto, Tsuyoshi Fukuda, Hiroshi Yamazaki

Biopharmaceutics & drug disposition 40(9) 350-357 2019年11月査読有り
Extrapolation of Hepatic Concentrations of Industrial Chemicals Using Pharmacokinetic Models to Predict Hepatotoxicity.

Hiroshi Yamazaki, Yusuke Kamiya

Toxicological research 35(4) 295-301 2019年10月査読有り
Steady-State Human Pharmacokinetics of Monobutyl Phthalate Predicted by Physiologically Based Pharmacokinetic Modeling Using Single-Dose Data from Humanized-Liver Mice Orally Administered with Dibutyl Phthalate.

Tomonori Miura, Shotaro Uehara, Sawa Mizuno, Manae Yoshizawa, Norie Murayama, Yusuke Kamiya, Makiko Shimizu, Hiroshi Suemizu, Hiroshi Yamazaki

Chemical research in toxicology 32(2) 333-340 2019年2月18日査読有り

もっとみる

MISC

モデルを用いた化学物質経口投与後の吸収,体内動態と肝毒性発現リスクの予測

神矢佑輔, 山崎浩史

CICSJ Bulletin (Web) 36(3) 55(J‐STAGE) 2018年

共同研究・競争的資金等の研究課題

吸収過程を考慮した生理学的薬物動態モデルを基盤とする化学物質肝毒性評価法の確立

日本学術振興会科学研究費助成事業若手研究若手研究 2019年4月 - 2021年3月

神矢佑輔

神矢佑輔

基本情報

研究分野

論文

MISC

共同研究・競争的資金等の研究課題

メニュー

共著者の一覧