Sugiyama Daisuke - My portal

Profile Information

Researcher number: 90759375
J-GLOBAL ID: 201801014116986492
researchmap Member ID: B000335359

Research Areas

Life sciences / Immunology /

Papers

Importance of lymph node immune responses in MSI-H/dMMR colorectal cancer

Koji Inamori, Yosuke Togashi, Shota Fukuoka, Kiwamu Akagi, Kouetsu Ogasawara, Takuma Irie, Daisuke Motooka, Yoichi Kobayashi, Daisuke Sugiyama, Motohiro Kojima, Norihiko Shiiya, Shota Nakamura, Shoichi Maruyama, Yutaka Suzuki, Masaaki Ito, Hiroyoshi Nishikawa

JCI Insight, 6(9), May 10, 2021
Flow cytometry analysis of peripheral Tregs in patients with multiple myeloma under lenalidomide maintenance.

Kenji Nozaki, Yuki Fujioka, Daisuke Sugiyama, Jun Ishikawa, Masato Iida, Masaru Shibata, Satoru Kosugi, Hiroyoshi Nishikawa, Hirohiko Shibayama

International journal of hematology, Feb 8, 2021
A simple method to distinguish residual elotuzumab from monoclonal paraprotein in immunofixation assays for multiple myeloma patients.

Shurui Chen, Toru Kiguchi, Yasuyuki Nagata, Yotaro Tamai, Takeshi Ikeda, Ryoko Kajiya, Takaaki Ono, Daisuke Sugiyama, Hiroyoshi Nishikawa, Yoshiki Akatsuka

International journal of hematology, 113(4) 473-479, Jan 28, 2021
Newly emerged immunogenic neoantigens in established tumors enable hosts to regain immunosurveillance in a T-cell-dependent manner.

Tomoaki Muramatsu, Takuro Noguchi, Daisuke Sugiyama, Yoshie Kanada, Kaori Fujimaki, Sachiko Ito, Momokazu Gotoh, Hiroyoshi Nishikawa

International immunology, 33(1) 39-48, Jan 1, 2021
Endoscopic Activity and Serum TNF-α Level at Baseline Are Associated With Clinical Response to Ustekinumab in Crohn's Disease Patients.

Kentaro Murate, Keiko Maeda, Masanao Nakamura, Daisuke Sugiyama, Hirotaka Wada, Takeshi Yamamura, Tsunaki Sawada, Yasuyuki Mizutani, Takuya Ishikawa, Kazuhiro Furukawa, Eizaburo Ohno, Takashi Honda, Hiroki Kawashima, Ryoji Miyahara, Masatoshi Ishigami, Hiroyoshi Nishikawa, Mitsuhiro Fujishiro

Inflammatory bowel diseases, 26(11) 1669-1681, Oct 23, 2020
The potential application of PD-1 blockade therapy for early-stage biliary tract cancer.

Kumiko Umemoto, Yosuke Togashi, Yasuhito Arai, Hiromi Nakamura, Shinichiro Takahashi, Tokiyoshi Tanegashima, Mikiya Kato, Tsubasa Nishikawa, Daisuke Sugiyama, Motohiro Kojima, Naoto Gotohda, Takeshi Kuwata, Masafumi Ikeda, Tatsuhiro Shibata, Hiroyoshi Nishikawa

International immunology, 32(4) 273-281, Apr 12, 2020
Tyrosine kinase inhibitor imatinib augments tumor immunity by depleting effector regulatory T cells.

Atsushi Tanaka, Hiroyoshi Nishikawa, Shinsuke Noguchi, Daisuke Sugiyama, Hiromasa Morikawa, Yoshiko Takeuchi, Danbee Ha, Naoya Shigeta, Toshio Kitawaki, Yuka Maeda, Takuro Saito, Yoshinori Shinohara, Yoshihiro Kameoka, Keiko Iwaisako, Fumihiko Monma, Kohshi Ohishi, Julia Karbach, Elke Jäger, Kenichi Sawada, Naoyuki Katayama, Naoto Takahashi, Shimon Sakaguchi

The Journal of experimental medicine, 217(2), Feb 3, 2020
Selective inhibition of low-affinity memory CD8+ T cells by corticosteroids.

Akihiro Tokunaga, Daisuke Sugiyama, Yuka Maeda, Allison Betof Warner, Katherine S Panageas, Sachiko Ito, Yosuke Togashi, Chika Sakai, Jedd D Wolchok, Hiroyoshi Nishikawa

The Journal of experimental medicine, 216(12) 2701-2713, Dec 2, 2019
Immune Suppression by PD-L2 against Spontaneous and Treatment-Related Antitumor Immunity.

Tokiyoshi Tanegashima, Yosuke Togashi, Koichi Azuma, Akihiko Kawahara, Ko Ideguchi, Daisuke Sugiyama, Fumio Kinoshita, Jun Akiba, Eiji Kashiwagi, Ario Takeuchi, Takuma Irie, Katsunori Tatsugami, Tomoaki Hoshino, Masatoshi Eto, Hiroyoshi Nishikawa

Clinical cancer research : an official journal of the American Association for Cancer Research, 25(15) 4808-4819, Aug 1, 2019
Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti-CTLA-4 antibody.

Danbee Ha, Atsushi Tanaka, Tatsuya Kibayashi, Atsushi Tanemura, Daisuke Sugiyama, James Badger Wing, Ee Lyn Lim, Karen Wei Weng Teng, Dennis Adeegbe, Evan W Newell, Ichiro Katayama, Hiroyoshi Nishikawa, Shimon Sakaguchi

Proceedings of the National Academy of Sciences of the United States of America, 116(2) 609-618, Jan 8, 2019
大腸癌における免疫学的な新たな分類と新規がん免疫療法の可能性

冨樫庸介, 稲守宏治, 福岡聖大, 杉山大介, 伊藤雅昭, 西川博嘉

日本がん免疫学会総会プログラム・抄録集, 22回 83-83, Jul, 2018
Identification of Tumoricidal TCRs from Tumor-Infiltrating Lymphocytes by Single-Cell Analysis.

Kiyomi Shitaoka, Hiroshi Hamana, Hiroyuki Kishi, Yoshihiro Hayakawa, Eiji Kobayashi, Kenta Sukegawa, Xiuhong Piao, Fulian Lyu, Takuya Nagata, Daisuke Sugiyama, Hiroyoshi Nishikawa, Atsushi Tanemura, Ichiro Katayama, Mutsunori Murahashi, Yasushi Takamatsu, Kenzaburo Tani, Tatsuhiko Ozawa, Atsushi Muraguchi

Cancer immunology research, 6(4) 378-388, Apr, 2018
Clinical impact of pre-transplant gut microbial diversity on outcomes of allogeneic hematopoietic stem cell transplantation.

Noriko Doki, Masahiro Suyama, Satoshi Sasajima, Junko Ota, Aiko Igarashi, Iyo Mimura, Hidetoshi Morita, Yuki Fujioka, Daisuke Sugiyama, Hiroyoshi Nishikawa, Yutaka Shimazu, Wataru Suda, Kozue Takeshita, Koji Atarashi, Masahira Hattori, Eiichi Sato, Kyoko Watakabe-Inamoto, Kosuke Yoshioka, Yuho Najima, Takeshi Kobayashi, Kazuhiko Kakihana, Naoto Takahashi, Hisashi Sakamaki, Kenya Honda, Kazuteru Ohashi

Annals of hematology, 96(9) 1517-1523, Sep, 2017
Fecal microbiota transplantation for patients with steroid-resistant acute graft-versus-host disease of the gut.

Kazuhiko Kakihana, Yuki Fujioka, Wataru Suda, Yuho Najima, Go Kuwata, Satoshi Sasajima, Iyo Mimura, Hidetoshi Morita, Daisuke Sugiyama, Hiroyoshi Nishikawa, Masahira Hattori, Yutaro Hino, Shuntaro Ikegawa, Keita Yamamoto, Takashi Toya, Noriko Doki, Koichi Koizumi, Kenya Honda, Kazuteru Ohashi

Blood, 128(16) 2083-2088, Oct 20, 2016
Two FOXP3(+)CD4(+) T cell subpopulations distinctly control the prognosis of colorectal cancers.

Takuro Saito, Hiroyoshi Nishikawa, Hisashi Wada, Yuji Nagano, Daisuke Sugiyama, Koji Atarashi, Yuka Maeda, Masahide Hamaguchi, Naganari Ohkura, Eiichi Sato, Hirotsugu Nagase, Junichi Nishimura, Hirofumi Yamamoto, Shuji Takiguchi, Takeshi Tanoue, Wataru Suda, Hidetoshi Morita, Masahira Hattori, Kenya Honda, Masaki Mori, Yuichiro Doki, Shimon Sakaguchi

Nature medicine, 22(6) 679-84, Jun, 2016
Sialyl Lewis x (CD15s) identifies highly differentiated and most suppressive FOXP3high regulatory T cells in humans.

Makoto Miyara, Driss Chader, Edouard Sage, Daisuke Sugiyama, Hiroyoshi Nishikawa, Diane Bouvry, Laetitia Claër, Ravi Hingorani, Robert Balderas, Jurg Rohrer, Noel Warner, Alain Chapelier, Dominique Valeyre, Reiji Kannagi, Shimon Sakaguchi, Zahir Amoura, Guy Gorochov

Proceedings of the National Academy of Sciences of the United States of America, 112(23) 7225-30, Jun 9, 2015
Detection of self-reactive CD8⁺ T cells with an anergic phenotype in healthy individuals.

Yuka Maeda, Hiroyoshi Nishikawa, Daisuke Sugiyama, Danbee Ha, Masahide Hamaguchi, Takuro Saito, Megumi Nishioka, James B Wing, Dennis Adeegbe, Ichiro Katayama, Shimon Sakaguchi

Science (New York, N.Y.), 346(6216) 1536-40, Dec 19, 2014
Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans.

Daisuke Sugiyama, Hiroyoshi Nishikawa, Yuka Maeda, Megumi Nishioka, Atsushi Tanemura, Ichiro Katayama, Sachiko Ezoe, Yuzuru Kanakura, Eiichi Sato, Yasuo Fukumori, Julia Karbach, Elke Jäger, Shimon Sakaguchi

Proceedings of the National Academy of Sciences of the United States of America, 110(44) 17945-50, Oct 29, 2013
Overcoming regulatory T-cell suppression by a lyophilized preparation of Streptococcus pyogenes.

Michiko Hirayama, Hiroyoshi Nishikawa, Yasuhiro Nagata, Takemasa Tsuji, Takuma Kato, Shinichi Kageyama, Shugo Ueda, Daisuke Sugiyama, Sahoko Hori, Shimon Sakaguchi, Gerd Ritter, Lloyd J Old, Sacha Gnjatic, Hiroshi Shiku

European journal of immunology, 43(4) 989-1000, Apr, 2013
Cancer/testis antigens are novel targets of immunotherapy for adult T-cell leukemia/lymphoma.

Hiroyoshi Nishikawa, Yuka Maeda, Takashi Ishida, Sacha Gnjatic, Eiichi Sato, Fumiko Mori, Daisuke Sugiyama, Asahi Ito, Yasuo Fukumori, Atae Utsunomiya, Hiroshi Inagaki, Lloyd J Old, Ryuzo Ueda, Shimon Sakaguchi

Blood, 119(13) 3097-104, Mar 29, 2012

Research Projects

TRPV1シグナル活性化による新規がん免疫応答メカニズムの解明

科学研究費助成事業若手研究, 日本学術振興会, Apr, 2019 - Mar, 2022

杉山大介
Identification of new molecule for regulatory T cells in an anti-tumor immunity

Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity Start-up, Japan Society for the Promotion of Science, Aug, 2015 - Mar, 2017

Sugiyama Daisuke, Nishikawa Hiroyoshi, Doi Toshihiko