論文

査読有り
2010年9月

Effect of Mastication on Functional Recoveries after Permanent Middle Cerebral Artery Occlusion in Rats

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
  • Katsuya Kawanishi
  • ,
  • Hisashi Koshino
  • ,
  • Yoshifumi Toyoshita
  • ,
  • Maki Tanaka
  • ,
  • Toshihiro Hirai

19
5
開始ページ
398
終了ページ
403
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.jstrokecerebrovasdis.2009.07.011
出版者・発行元
ELSEVIER SCIENCE BV

Objectives: We evaluated whether solid feed is more effective for functional recoveries than liquid feed in rats with ischemic brain injury after permanent middle cerebral artery occlusion (MCAO). Methods: A total of 36 male Wistar/ST rats were subjected to MCAO or sham surgery. After MCAO or sham surgery, all rats were provided liquid feed for 14 days. Then, all rats were divided into 3 groups: the solid feeding group, the liquid feeding group, and the solid feeding group of sham. Effect of mastication on functional recoveries after permanent MCAO in rats was evaluated by the limb placement test and Morris water maze (MWM) task. Results: After surgery, limb placement test scores were equal in both MCAO groups. In the acquisition trials of MWM task, statistically significant differences in escape latency were observed between the liquid feeding group and sham groups at all days, and between the solid feeding group and sham groups at days 3 and 4 of the trials. In the probe trial, statistically significant differences in time spent were observed between the liquid feeding group and sham group. On day 5 of acquisition trials, the time spent in the periphery of the pool in MWM task was significantly different among the 3 groups. Conclusion: This study suggested that solid diet mastication could be effective for the rehabilitation of sensorimotor and learning/memory dysfunction induced by cerebral infarction.

Web of Science ® 被引用回数 : 13

リンク情報
DOI
https://doi.org/10.1016/j.jstrokecerebrovasdis.2009.07.011
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/20472469
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000281931400012&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.jstrokecerebrovasdis.2009.07.011
  • ISSN : 1052-3057
  • eISSN : 1532-8511
  • PubMed ID : 20472469
  • Web of Science ID : WOS:000281931400012

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