論文

査読有り 国際誌
2018年9月

Microarray-Based Multivariate Analysis of the Effectiveness of Sublingual Immunotherapy for Cedar Pollinosis.

Allergy, asthma & immunology research
  • Minoru Gotoh
  • ,
  • Osamu Kaminuma
  • ,
  • Takachika Hiroi
  • ,
  • Kimihiro Okubo

10
5
開始ページ
562
終了ページ
569
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.4168/aair.2018.10.5.562

Sublingual immunotherapy (SLIT) is an effective treatment for allergic diseases. However, the mechanism by which this therapy exhibits its efficacy has not been fully delineated. To elucidate the mechanisms of SLIT in the treatment of cedar pollinosis (CP), we performed a multivariate analysis of microarray data on mRNA expression in CD4⁺ T cells and basophils. Although 2-year treatment with SLIT using cedar extracts was effective in >70% of patients with CP, the remaining patients did not respond to this therapy. The mRNA expression levels in peripheral CD4⁺ T cells and basophils from both high- and non-responder patients before and after undergoing SLIT were comparatively studied using microarray analysis. By processing the data using serial multivariate analysis, an apoptosis pathway was extracted in both CD4⁺ T cells and basophils. Conclusively, the strong treatment effectiveness of SLIT in patients with CP may be caused by the induction of apoptosis in CD4⁺ T cells and basophils in these patients (Trial registry at University Hospital Medical Information Network Clinical Trials Registry Database, UMIN000016532).

リンク情報
DOI
https://doi.org/10.4168/aair.2018.10.5.562
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30088375
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082820

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