論文

査読有り 国際誌
2018年2月

Contribution of neuraminidase 3 to the differentiation of induced regulatory T cells.

Genes to cells : devoted to molecular & cellular mechanisms
  • Osamu Kaminuma
  • ,
  • Shigeki Katoh
  • ,
  • Taeko Miyagi
  • ,
  • Nobumasa Watanabe
  • ,
  • Noriko Kitamura
  • ,
  • Tomoe Nishimura
  • ,
  • Mayumi Saeki
  • ,
  • Akio Mori
  • ,
  • Takachika Hiroi

23
2
開始ページ
112
終了ページ
116
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/gtc.12553
出版者・発行元
Blackwell Publishing Ltd

Neuraminidase family enzymes that hydrolyze the terminal sialic acid linkage in biomolecules are involved in various immune responses. We previously showed that Th1 and Th2 cells differentially express several neuraminidases. Herein, the expression of neuraminidases in induced regulatory T (iTreg) cells was investigated in comparison with that in other T-cell subsets. Contrary to the tendency toward higher neuraminidase 1 mRNA expression in in vitro-differentiated Th2 cells, compared to Th1, Th17 and iTreg cells, we observed significantly higher expression of neuraminidase 3 (Neu3) in iTreg cells. Furthermore, the expression of Neu3 in FoxP3+ CD62L- spleen cells was higher than that in FoxP3+ CD62L+ and FoxP3- cells. Lentiviral expression of Neu3 in naïve CD4+ T cells during the stimulation culture led to upregulation of FoxP3 expression. On the basis of these findings, we conclude that Neu3 contributes to the differentiation of iTreg cells by upregulation of FoxP3.

リンク情報
DOI
https://doi.org/10.1111/gtc.12553
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29271120

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