論文

査読有り
2007年

IL-9 production by peripheral blood mononuclear cells of atopic asthmatics

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
  • Makiko Umezu-Goto
  • ,
  • Yuichiro Kajiyama
  • ,
  • Noriaki Kobayashi
  • ,
  • Osamu Kaminuma
  • ,
  • Matsunobu Suko
  • ,
  • Akio Mori

143
開始ページ
76
終了ページ
79
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1159/000101410
出版者・発行元
KARGER

Background: IL-9 might play a critical role in pathogenesis and development of atopic asthma, but there are few reports on allergen-specific IL-9 production by peripheral blood mononuclear cells (PBMCs) obtained from adult asthmatics. Methods: PBMCs were obtained from adult atopic asthmatics and incubated with Dermatophagoides farinae (Der f) extract for the designated time periods. The resulting supernatants were assayed for IL-9 by specific sandwich ELISA. Results: IL-9 production was detectable on day 2 and reached maximum on day 6 after stimulation of PBMCs with Der f extract. IL-9 production in response to Der f extract increased in a dose-dependent manner. CD2- or CD4-bearing cell depletion completely abolished IL-9 production by PBMCs, while CD8-bearing cell depletion did not affect it. Conclusion: CD4+ lymphocytes are the principal source of IL-9 produced by PBMCs of adult atopic asthmatics. Copyright (C) 2007 S. Karger AG, Basel.


リンク情報
DOI
https://doi.org/10.1159/000101410
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000247527500014&DestApp=WOS_CPL
ID情報
  • DOI : 10.1159/000101410
  • ISSN : 1018-2438
  • Web of Science ID : WOS:000247527500014

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