論文

査読有り
2020年3月11日

Association of Basophil-Expressing Genes with Effectiveness of Sublingual Immunotherapy.

Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
  • Minoru Gotoh
  • ,
  • Osamu Kaminuma
  • ,
  • Akihiro Nakaya
  • ,
  • Mayumi Saeki
  • ,
  • Tomoe Nishimura
  • ,
  • Noriko Kitamura
  • ,
  • Takachika Hiroi
  • ,
  • Kimihiro Okubo

87
1
開始ページ
49
終了ページ
52
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1272/jnms.JNMS.2020_87-104

Basophils were reported to be associated with allergy pathogenesis and the efficacy of allergen immunotherapy. Using a purified cedar allergen, we recently studied the effectiveness of sublingual immunotherapy for patients with Japanese cedar pollinosis. Patients were classified as high responders (HR) and nonresponders (NR), and comprehensive microarray analysis was used to examine peripheral basophils in both groups. A total of 153 genes were differentially expressed in HR and NR patients. Most of these differentially expressed genes encoded intracellular molecules, and expression levels were higher in HR patients than in NR patients. mRNA expression of the gene encoding D4, zinc, and double plant homeodomain (PHD) fingers family 2 (DPF2) was significantly correlated with copy number variation (CNV). Genetic variation in the DPF2 gene and its expression in basophils might be associated with the efficacy of sublingual immunotherapy.

リンク情報
DOI
https://doi.org/10.1272/jnms.JNMS.2020_87-104
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31564689

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