1997年1月1日
Development of Lung Eosinophilic Inflammation by the Infusion of IL-5-Producing T Cell Clones
International Archives of Allergy and Immunology
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- 巻
- 114
- 号
- 1
- 開始ページ
- 10
- 終了ページ
- 13
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1159/000237709
To delineate the critical role of T cells on asthma, we tested whether eosinophilic inflammation of the bronchial mucosa is induced by transfer of IL-5-producing T cell clones, in the absence of antigen-specific immunoglobulins (IgE, A and G). Ovalbumin-specific T cell clone, FI5, that produced IL-5 upon challenge with relevant antigen was established. Eosinophilic inflammation of the lung occurred when unprimed mice were transferred with FI5 and challenged by the inhaled antigen. Eosinophil infiltration was completely suppressed by the administration of anti-IL-5 neutralizing antibody, indicating the essential role of IL-5. We concluded that the existence of IL-5-producing helper T cells is sufficient for the development of airway eosinophilic inflammation. © 1997 S. Karger AG, Basel.
- ID情報
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- DOI : 10.1159/000237709
- ISSN : 1423-0097
- ISSN : 1018-2438
- PubMed ID : 9363917
- SCOPUS ID : 0030665522