1999年
p38 mitogen-activated protein kinase regulates human T cell IL-5 synthesis
Journal of Immunology
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- 巻
- 163
- 号
- 9
- 開始ページ
- 4763
- 終了ページ
- 4771
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
Involvement of p38 mitogen-activated protein (MAP) kinase in human T cell cytokine synthesis was investigated, p38 MAP kinase was clearly induced in human Th cells activated through the TCR. SB203580, a highly selective inhibitor of p38 MAP kinase, inhibited the induction of p38 MAP kinase in human Th cells. Major T cell cytokines, IL-2, IL-4, IL-5, and IFN-γ were produced by Der f 2-specific Th clones upon stimulation through the TCR. IL-5 synthesis alone was significantly inhibited by SB203580 in a dose-dependent manner, whereas the production of IL-2, IL-4, and IFN-γ was not affected. The proliferation of activated T cells was not affected. IL-5 synthesis of human Th clones induced upon stimulation with rIL-2, phorbol ester plus anti- CD28 mAb, and immobilized anti-CD3 mAb plus soluble anti-CD28 mAb was also suppressed by SB203580 in the same concentration response relationship. The results clearly indicated that IL-5 synthesis by human Th cells is dependent on p38 MAP kinase activity, and is regulated distinctly from IL-2, IL-4, and IFN-γ synthesis. Selective control of IL-5 synthesis will provide a novel treatment devoid of generalized immune suppression for bronchial asthma and atopic dermatitis that are characterized by eosinophilic inflammation.
- リンク情報
- ID情報
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- ISSN : 0022-1767
- PubMed ID : 10528175
- SCOPUS ID : 0032711893