論文

査読有り
2020年

T Cell-Mediated Nasal Hyperresponsiveness in Allergic Rhinitis.

Biological & pharmaceutical bulletin
  • Osamu Kaminuma
  • ,
  • Tomoe Nishimura
  • ,
  • Mayumi Saeki
  • ,
  • Akio Mori
  • ,
  • Takachika Hiroi

43
1
開始ページ
36
終了ページ
40
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1248/bpb.b18-01021

Allergic rhinitis patients suffer various symptoms such as sneezing, runny nose, and nasal congestion. As disease severity and chronicity progress, nasal hyperresponsiveness (NHR) develops in those patients. During the generation of a mouse allergic rhinitis model, we discovered that immunized mice developed NHR upon repeated nasal antigen challenge. Using genetically modified mice and an originally developed T cell-transferred mouse model, we confirmed the critical role of CD4+ T cells after differentiation into several helper subsets in NHR. On the other hand, immunoglobulin E/mast cell-dependent responses that are critical for evoking nasal symptoms and eosinophils that accumulate in allergic inflammation sites were dispensable. A steroid, but not drugs targeting mast cell-derived mediators, was effective in alleviating NHR. The possible generation of a new means to treat allergic rhinitis by targeting T cell-derived NHR-inducing factors is suggested.

リンク情報
DOI
https://doi.org/10.1248/bpb.b18-01021
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31902929

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