1993年9月
ANTITUMOR EFFECT OF THE ANGIOGENESIS INHIBITOR AGM-1470 AND ITS COMBINATION EFFECT WITH TAMOXIFEN IN DMBA INDUCED MAMMARY-TUMORS IN RATS
INTERNATIONAL JOURNAL OF ONCOLOGY
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- 巻
- 3
- 号
- 3
- 開始ページ
- 525
- 終了ページ
- 528
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- 出版者・発行元
- INT JOURNAL ONCOLOGY
AGM-1470 is known to inhibit angiogenesis. It inhibited the mitogen induced cell growth in microvascular endothelial cells in vitro. Ten ng/ml AGM-1470 completely inhibited both basic fibroblast growth factor induced cell growth, and interleukin-4 induced cell growth. In an in vivo study, we invesigated the antitumor effect of AGM-1470 in dimethylbenz[a]anthracene (DMBA) induced rat mammary tumors. A dose dependent growth inhibition was seen between administered doses 10 mg/kg and 40 mg/kg. Forty mg/kg 2-week administration of AGM-1470 totally suppressed the tumor growth. In addition, an additive inhibitory effect of AGM-1470 with an antiestrogen tamoxifen was found (p<0.01). It is suggested that the combination of these two drugs might be effective for the treatment of breast cancer.
- リンク情報
- ID情報
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- ISSN : 1019-6439
- Web of Science ID : WOS:A1993LQ90200016