論文

査読有り
2001年11月

Vascular endothelial growth factor: its prognostic, predictive, and therapeutic implications

LANCET ONCOLOGY
  • M Toi
  • ,
  • T Matsumoto
  • ,
  • H Bando

2
11
開始ページ
667
終了ページ
673
記述言語
英語
掲載種別
DOI
10.1016/S1470-2045(01)00556-3
出版者・発行元
LANCET LTD

Since the discovery that cancer development requires the growth of new blood vessels, many investigations have revealed the key molecules in the regulation of new vessel formation. One of the most important of these molecules is vascular endothelial growth factor (VEGF) - an endothelial-cell-specific mitogen and survival factor. VEGF also causes increased vascular permeability and recruits progenitor endothelial cells from the bone marrow. Clinical observations have confirmed that VEGF status is closely associated with the extent of neovascularisation and prognosis in many solid tumours. VEGF status is predictive of resistance to various treatments, including radiotherapy, chemotherapy, and endocrine therapy. Preliminary results also indicate that anti-VEGF treatment suppresses cancer progression without serious toxic effects. Various approaches for the control of cancers involving inhibition of the activity of VEGF are currently being investigated. This review considers the clinical implications of VEGF, particularly its prognostic, predictive, and therapeutic value.

リンク情報
DOI
https://doi.org/10.1016/S1470-2045(01)00556-3
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000174092400019&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/S1470-2045(01)00556-3
  • ISSN : 1470-2045
  • Web of Science ID : WOS:000174092400019

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