2005年10月
Serum lipid profiles in patients receiving endocrine treatment for breast cancer - the results from the Celecoxib Anti-Aromatase Neoadjuvant (CAAN) Trial
BIOMEDICINE & PHARMACOTHERAPY
- ,
- ,
- ,
- 巻
- 59
- 号
- SUPPL. 2
- 開始ページ
- S302
- 終了ページ
- S305
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/S0753-3322(05)80051-4
- 出版者・発行元
- ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Background. - Anti-aromatase therapy is important in the treatment of breast cancer. Cyclooxygenase-2 (COX-2) inhibitors may be effective in chernoprevention. A proof of principle study was performed to investigate the efficacy and side effects including changes in lipid profiles of combining anti-aromatase therapy and COX-2 inhibitor preoperatively in hormone sensitive postmenopausal breast cancers.
Methods. - From February 2002 to April 2003, 41 postmenopausal women with histologically proven LABC were recruited. The patients were randomly assigned to receive exemestane 25 mg daily and celecoxib 400 mg twice-daily (group A), exemestane 25 mg daily (group 13) and letrozole 2.5 mg daily (group Q.
Results. - Observed clinical response rates were 61.5%, 60% and 54.5% for Groups A-C, respectively, with no pathologic complete response. Cholesterol levels for Group A dropped progressively and a statistical difference was observed between fifth week after operation and preoperative level (P = 0.026). In addition, Group A has significantly lowered cholesterol and LDL levels than Groups B and C after 18 weeks of treatment.
Conclusion. - The initial results show that different neoadjuvant anti-aromatase therapies has similar efficacy but the combination with celecoxib may have an advantageous effects on the serum lipid profiles. (c) 2005 Elsevier SAS. All rights reserved.
Methods. - From February 2002 to April 2003, 41 postmenopausal women with histologically proven LABC were recruited. The patients were randomly assigned to receive exemestane 25 mg daily and celecoxib 400 mg twice-daily (group A), exemestane 25 mg daily (group 13) and letrozole 2.5 mg daily (group Q.
Results. - Observed clinical response rates were 61.5%, 60% and 54.5% for Groups A-C, respectively, with no pathologic complete response. Cholesterol levels for Group A dropped progressively and a statistical difference was observed between fifth week after operation and preoperative level (P = 0.026). In addition, Group A has significantly lowered cholesterol and LDL levels than Groups B and C after 18 weeks of treatment.
Conclusion. - The initial results show that different neoadjuvant anti-aromatase therapies has similar efficacy but the combination with celecoxib may have an advantageous effects on the serum lipid profiles. (c) 2005 Elsevier SAS. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/S0753-3322(05)80051-4
- ISSN : 0753-3322
- Web of Science ID : WOS:000234423600011