酒井真志人 (Mashito Sakai) - マイポータル

基本情報

所属: 日本医科大学大学院医学研究科分子遺伝医学分野教授

学位: 博士(医学)(2012年3月神戸大学大学院)

研究者番号: 40643490
ORCID iD: https://orcid.org/0000-0002-4908-2727
J-GLOBAL ID: 202001006567624042
researchmap会員ID: R000008769

研究キーワード

研究分野

経歴

2020年8月 - 現在

日本医科大学, 大学院医学研究科分子遺伝医学分野, 教授
2016年4月 - 2020年6月

カリフォルニア大学サンディエゴ校, 研究員
2013年4月 - 2016年3月

国立国際医療研究センター研究所, 糖尿病研究センター分子代謝制御研究部, 室長

学歴

受賞

論文

Proline enhances the hepatic induction of lipogenic gene expression in male hepatic fasn reporter mice.

Akinori Taniguchi, Hitoshi Watanabe, Kumi Kimura, Emi Hashiuchi, Nami Ohashi, Hirofumi Sato, Mashito Sakai, Michihiro Matsumoto, Shun-Ichiro Asahara, Hiroshi Inoue …

Biochemical and biophysical research communications 747 151314-151314 2025年2月2日査読有り
Identification of coexisting Mfrprd6 and Pde6brd10 mutations causing spontaneous retinal detachment in commercially available rd6 mice.

Asaka Lee Shiozawa, Maika Hosoi Kobayashi, Yusuke Shiozawa, Yasuhiro Ikeda, Yoshitaka Miyagawa, Fumiki Okamoto, Mashito Sakai, Takashi Okada, Tsutomu Igarashi

PloS one 20(9) e0332446 2025年査読有り
Mesenchymal stem cell origin contributes to the antitumor effect of oncolytic virus carriers.

Makoto Sukegawa, Yoshitaka Miyagawa, Seiji Kuroda, Yoshiyuki Yamazaki, Motoko Yamamoto, Kumi Adachi, Hirofumi Sato, Yuriko Sato, Nobuhiko Taniai, Hiroshi Yoshida …

Molecular therapy. Oncology 32(4) 200896-200896 2024年12月19日査読有り責任著者
Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes and transcriptomes.

Hunter Bennett, Ty D Troutman, Enchen Zhou, Nathanael J Spann, Verena M Link, Jason S Seidman, Christian K Nickl, Yohei Abe, Mashito Sakai, Martina P Pasillas …

Nature immunology 24(11) 1825-1838 2023年11月査読有り
RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression.

Yohei Abe, Eric R Kofman, Maria Almeida, Zhengyu Ouyang, Filipa Ponte, Jasmine R Mueller, Grisel Cruz-Becerra, Mashito Sakai, Thomas A Prohaska, Nathanael J Spann …

Molecular cell 83(19) 3421-3437 2023年10月5日査読有り
iPSC-derived mesenchymal stem cells attenuate cerebral ischemia-reperfusion injury by inhibiting inflammatory signaling and oxidative stress.

Masafumi Arakawa, Yuki Sakamoto, Yoshitaka Miyagawa, Chikako Nito, Shiro Takahashi, Yuko Nitahara-Kasahara, Satoshi Suda, Yoshiyuki Yamazaki, Mashito Sakai, Kazumi Kimura …

Molecular therapy. Methods & clinical development 30 333-349 2023年9月14日査読有り
Hepatic FASN deficiency differentially affects nonalcoholic fatty liver disease and diabetes in mouse obesity models.

Toshiya Matsukawa, Takashi Yagi, Tohru Uchida, Mashito Sakai, Masaru Mitsushima, Takao Naganuma, Hiroyuki Yano, Yuka Inaba, Hiroshi Inoue, Keisuke Yanagida …

JCI insight 8(17) 2023年9月8日査読有り
SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity.

Bethany R Fixsen, Claudia Z Han, Yi Zhou, Nathanael J Spann, Payam Saisan, Zeyang Shen, Christopher Balak, Mashito Sakai, Isidoro Cobo, Inge R Holtman …

Nature immunology 24(7) 1188-1199 2023年7月査読有り
Exploring the signal-dependent transcriptional regulation involved in the liver pathology of type 2 diabetes.

Mashito Sakai

Diabetology international 14(1) 15-20 2023年1月査読有り責任著者
Systematic analysis of transcriptional and epigenetic effects of genetic variation in Kupffer cells enables discrimination of cell intrinsic and environment-dependent mechanisms

Hunter Bennett, Ty D. Troutman, Enchen Zhou, Nathanael J. Spann, Verena M. Link, Jason S. Seidman, Christian K. Nickl, Yohei Abe, Mashito Sakai, Martina P. Pasillas …

2022年9月23日査読有り
Drinking hydrogen water improves photoreceptor structure and function in retinal degeneration 6 mice.

Tsutomu Igarashi, Ikuroh Ohsawa, Maika Kobayashi, Kai Miyazaki, Toru Igarashi, Shuhei Kameya, Asaka Lee Shiozawa, Yasuhiro Ikeda, Yoshitaka Miyagawa, Mashito Sakai …

Scientific reports 12(1) 13610-13610 2022年8月10日査読有り
DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages.

Isidoro Cobo, Tiffany N Tanaka, Kailash Chandra Mangalhara, Addison Lana, Calvin Yeang, Claudia Han, Johannes Schlachetzki, Jean Challcombe, Bethany R Fixsen, Mashito Sakai …

Immunity 55(8) 1386-1401 2022年8月9日査読有り
The Lung Microenvironment Instructs Gene Transcription in Neonatal and Adult Alveolar Macrophages.

Asami Honda, Marten A Hoeksema, Mashito Sakai, Sean J Lund, Omar Lakhdari, Lindsay D Butcher, Tara C Rambaldo, Neal M Sekiya, Chanond A Nasamran, Kathleen M Fisch …

Journal of immunology (Baltimore, Md. : 1950) 208(8) 1947-1959 2022年4月15日査読有り
Systematic analysis of naturally occurring insertions and deletions that alter transcription factor spacing identifies tolerant and sensitive transcription factor pairs.

Zeyang Shen, Rick Z Li, Thomas A Prohaska, Marten A Hoeksema, Nathan J Spann, Jenhan Tao, Gregory J Fonseca, Thomas Le, Lindsey K Stolze, Mashito Sakai …

eLife 11 2022年1月20日査読有り
Purification of mouse hepatic non-parenchymal cells or nuclei for use in ChIP-seq and other next-generation sequencing approaches.

Ty D Troutman, Hunter Bennett, Mashito Sakai, Jason S Seidman, Sven Heinz, Christopher K Glass

STAR protocols 2(1) 100363-100363 2021年3月19日査読有り
An optimized protocol for rapid, sensitive and robust on-bead ChIP-seq from primary cells.

Lorane Texari, Nathanael J Spann, Ty D Troutman, Mashito Sakai, Jason S Seidman, Sven Heinz

STAR protocols 2(1) 100358-100358 2021年3月19日査読有り
Stepwise cell fate decision pathways during osteoclastogenesis at single-cell resolution.

Masayuki Tsukasaki, Nam Cong-Nhat Huynh, Kazuo Okamoto, Ryunosuke Muro, Asuka Terashima, Yoshitaka Kurikawa, Noriko Komatsu, Warunee Pluemsakunthai, Takeshi Nitta, Takaya Abe …

Nature metabolism 2(12) 1382-1390 2020年12月7日査読有り
Crystal structure of GCN5 PCAF N-terminal domain reveals atypical ubiquitin ligase structure.

Sachiko Toma-Fukai, Ryota Hibi, Takao Naganuma, Mashito Sakai, Shinya Saijo, Nobutaka Shimizu, Michihiro Matsumoto, Toshiyuki Shimizu

The Journal of biological chemistry 295(43) 14630-14639 2020年10月23日査読有り
Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis.

Jason S Seidman, Ty D Troutman, Mashito Sakai, Anita Gola, Nathanael J Spann, Hunter Bennett, Cassi M Bruni, Zhengyu Ouyang, Rick Z Li, Xiaoli Sun …

Immunity 52(6) 1057-1074 2020年6月16日査読有り筆頭著者
Epigenetic Regulation of Kupffer Cell Function in Health and Disease.

Hunter Bennett, Ty D Troutman, Mashito Sakai, Christopher K Glass

Frontiers in immunology 11 609618-609618 2020年査読有り