酒井真志人 (Mashito Sakai) - マイポータル

基本情報

所属: 日本医科大学大学院医学研究科分子遺伝医学分野教授

学位: 博士(医学)(2012年3月神戸大学大学院)

研究者番号: 40643490
ORCID iD: https://orcid.org/0000-0002-4908-2727
J-GLOBAL ID: 202001006567624042
researchmap会員ID: R000008769

研究キーワード

研究分野

経歴

2020年8月 - 現在

日本医科大学, 大学院医学研究科分子遺伝医学分野, 教授
2016年4月 - 2020年6月

カリフォルニア大学サンディエゴ校, 研究員
2013年4月 - 2016年3月

国立国際医療研究センター研究所, 糖尿病研究センター分子代謝制御研究部, 室長

学歴

受賞

論文

Mesenchymal stem cell origin contributes to the antitumor effect of oncolytic virus carriers.

Makoto Sukegawa, Yoshitaka Miyagawa, Seiji Kuroda, Yoshiyuki Yamazaki, Motoko Yamamoto, Kumi Adachi, Hirofumi Sato, Yuriko Sato, Nobuhiko Taniai, Hiroshi Yoshida …

Molecular therapy. Oncology 32(4) 200896-200896 2024年12月19日
Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes and transcriptomes.

Hunter Bennett, Ty D Troutman, Enchen Zhou, Nathanael J Spann, Verena M Link, Jason S Seidman, Christian K Nickl, Yohei Abe, Mashito Sakai, Martina P Pasillas …

Nature immunology 2023年9月21日
RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression.

Yohei Abe, Eric R Kofman, Maria Almeida, Zhengyu Ouyang, Filipa Ponte, Jasmine R Mueller, Grisel Cruz-Becerra, Mashito Sakai, Thomas A Prohaska, Nathanael J Spann …

Molecular cell 2023年9月14日
iPSC-derived mesenchymal stem cells attenuate cerebral ischemia-reperfusion injury by inhibiting inflammatory signaling and oxidative stress.

Masafumi Arakawa, Yuki Sakamoto, Yoshitaka Miyagawa, Chikako Nito, Shiro Takahashi, Yuko Nitahara-Kasahara, Satoshi Suda, Yoshiyuki Yamazaki, Mashito Sakai, Kazumi Kimura …

Molecular therapy. Methods & clinical development 30 333-349 2023年9月14日
Hepatic FASN deficiency differentially affects nonalcoholic fatty liver disease and diabetes in mouse obesity models.

Toshiya Matsukawa, Takashi Yagi, Tohru Uchida, Mashito Sakai, Masaru Mitsushima, Takao Naganuma, Hiroyuki Yano, Yuka Inaba, Hiroshi Inoue, Keisuke Yanagida …

JCI insight 8(17) 2023年9月8日
SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity.

Bethany R Fixsen, Claudia Z Han, Yi Zhou, Nathanael J Spann, Payam Saisan, Zeyang Shen, Christopher Balak, Mashito Sakai, Isidoro Cobo, Inge R Holtman …

Nature immunology 2023年6月15日
Exploring the signal-dependent transcriptional regulation involved in the liver pathology of type 2 diabetes

Mashito Sakai

Diabetology International 2023年1月
Systematic analysis of transcriptional and epigenetic effects of genetic variation in Kupffer cells enables discrimination of cell intrinsic and environment-dependent mechanisms

Hunter Bennett, Ty D. Troutman, Enchen Zhou, Nathanael J. Spann, Verena M. Link, Jason S. Seidman, Christian K. Nickl, Yohei Abe, Mashito Sakai, Martina P. Pasillas …

2022年9月23日
Drinking hydrogen water improves photoreceptor structure and function in retinal degeneration 6 mice.

Tsutomu Igarashi, Ikuroh Ohsawa, Maika Kobayashi, Kai Miyazaki, Toru Igarashi, Shuhei Kameya, Asaka Lee Shiozawa, Yasuhiro Ikeda, Yoshitaka Miyagawa, Mashito Sakai …

Scientific reports 12(1) 13610-13610 2022年8月10日
DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages.

Isidoro Cobo, Tiffany N Tanaka, Kailash Chandra Mangalhara, Addison Lana, Calvin Yeang, Claudia Han, Johannes Schlachetzki, Jean Challcombe, Bethany R Fixsen, Mashito Sakai …

Immunity 2022年8月4日
The Lung Microenvironment Instructs Gene Transcription in Neonatal and Adult Alveolar Macrophages.

Asami Honda, Marten A Hoeksema, Mashito Sakai, Sean J Lund, Omar Lakhdari, Lindsay D Butcher, Tara C Rambaldo, Neal M Sekiya, Chanond A Nasamran, Kathleen M Fisch …

Journal of immunology (Baltimore, Md. : 1950) 208(8) 1947-1959 2022年4月
Systematic analysis of naturally occurring insertions and deletions that alter transcription factor spacing identifies tolerant and sensitive transcription factor pairs.

Zeyang Shen, Rick Z Li, Thomas A Prohaska, Marten A Hoeksema, Nathan J Spann, Jenhan Tao, Gregory J Fonseca, Thomas Le, Lindsey K Stolze, Mashito Sakai …

eLife 11 2022年1月20日
Purification of mouse hepatic non-parenchymal cells or nuclei for use in ChIP-seq and other next-generation sequencing approaches

Ty D. Troutman, Hunter Bennett, Mashito Sakai, Jason S. Seidman, Sven Heinz, Christopher K. Glass

STAR Protocols 2(1) 100363-100363 2021年3月
An optimized protocol for rapid, sensitive and robust on-bead ChIP-seq from primary cells

Lorane Texari, Nathanael J. Spann, Ty D. Troutman, Mashito Sakai, Jason S. Seidman, Sven Heinz

STAR Protocols 2(1) 100358-100358 2021年3月
Epigenetic Regulation of Kupffer Cell Function in Health and Disease.

Mashito Sakai

Frontiers in immunology 11 2021年1月26日
Stepwise cell fate decision pathways during osteoclastogenesis at single-cell resolution.

Masayuki Tsukasaki, Nam Cong-Nhat Huynh, Kazuo Okamoto, Ryunosuke Muro, Asuka Terashima, Yoshitaka Kurikawa, Noriko Komatsu, Warunee Pluemsakunthai, Takeshi Nitta, Takaya Abe …

Nature metabolism 2(12) 1382-1390 2020年12月7日
Crystal structure of GCN5 PCAF N-terminal domain reveals atypical ubiquitin ligase structure

Sachiko Toma-Fukai, Ryota Hibi, Takao Naganuma, Mashito Sakai, Shinya Saijo, Nobutaka Shimizu, Michihiro Matsumoto, Toshiyuki Shimizu

Journal of Biological Chemistry 295(43) 14630-14639 2020年10月23日
Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis.

Jason S Seidman, Ty D Troutman, Mashito Sakai, Anita Gola, Nathanael J Spann, Hunter Bennett, Cassi M Bruni, Zhengyu Ouyang, Rick Z Li, Xiaoli Sun …

Immunity 52(6) 1057-1074 2020年6月16日査読有り
Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity.

Mashito Sakai, Ty D Troutman, Jason S Seidman, Zhengyu Ouyang, Nathanael J Spann, Yohei Abe, Kaori M Ego, Cassi M Bruni, Zihou Deng, Johannes C M Schlachetzki …

Immunity 51(4) 655-670 2019年10月15日査読有り
Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages.

Gregory J Fonseca, Jenhan Tao, Emma M Westin, Sascha H Duttke, Nathanael J Spann, Tobias Strid, Zeyang Shen, Joshua D Stender, Mashito Sakai, Verena M Link …

Nature communications 10(1) 414-414 2019年1月24日査読有り