2011年9月28日
Alpha-fetoprotein-producing pancreatic cancer cells possess cancer stem cell characteristics.
Cancer letters
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- 巻
- 308
- 号
- 2
- 開始ページ
- 152
- 終了ページ
- 61
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.canlet.2011.04.023
We aimed to demonstrate the existence of cancer stem cells in human pancreatic cancer, and to clarify that they are alpha-fetoprotein (AFP) producing cells. Six cell lines derived from human pancreatic cancers were examined, and AsPC-1 and PANC-1 were noted to express AFP. Single cell culture assays and xenotransplantation revealed that the AFP-producing cells had the capacity for self-renewal and differentiation, and that these cells were tumorigenic. Furthermore, they were resistant to anti-cancer agents. The ABCA12 transporter was expressed in the AFP-producing cells at a level more than twice as high as that in the non-AFP-producing cells. The AFP-producing cells were shown to be putative pancreatic cancer stem cells. Furthermore, the expression of ABCA12 appears to be associated with drug resistance.
- リンク情報
- ID情報
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- DOI : 10.1016/j.canlet.2011.04.023
- PubMed ID : 21616586