2012年9月
Effect of lignin-derived lignophenols on hepatic lipid metabolism in rats fed a high-fat diet
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
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- 巻
- 34
- 号
- 2
- 開始ページ
- 228
- 終了ページ
- 234
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.etap.2012.04.005
- 出版者・発行元
- ELSEVIER SCIENCE BV
The effect of lignin-derived lignophenols on lipid metabolism in the livers of rats fed a high-fat diet was investigated. Rats fed a diet providing 45% of energy from fat were divided into 2 groups, namely 0% and 0.5% lignophenols-containing diets. The controls were fed a diet providing 10% of energy from fat. Plasma blood parameters, protein expression of acetyl-CoA carboxylase (ACC) and sterol regulatory element-binding protein (SREBP)-1, and SREBP-1c mRNA expression in the livers were examined. The plasma triglyceride levels in the rats fed lignophenols-containing diets were decreased. SREBP-1c mRNA expression in the rats fed lignophenols-containing diets was significantly reduced compared with the rats fed high-fat diets, and phosphorylated ACC protein in the rats fed lignophenols-containing diets was significantly increased. Our results suggested that lignophenols suppress the expression of SREBP-1c mRNA and the phosphorylation of ACC in the liver, and may lead to a decrease in plasma triglyceride levels. (C) 2012 Elsevier B.V. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.etap.2012.04.005
- ISSN : 1382-6689
- Web of Science ID : WOS:000313155600014