- ZOOLOGICAL SOC JAPAN
The differentiation patterns of animal cap explants from the Japanese salamanders Hynobius lichenatus and Hynobius nigrescens were examined after exposure to various concentrations of activin A. A wide range of concentrations of activin A (0.5-100 ng/ml) induced various mesodermal tissues such as ventral mesoderm, semitic muscle, and notochord. At concentrations higher than 50 ng/ml, yolk-rich endodermal tissue was induced in many of the explants. Activin A is also known to have mesoderm- and/or endoderm-inducing activity on the animal caps of Xenopus laevis and Cynops pyrrhogaster, but their response patterns are slightly different. The mode of differentiation of activin-treated Hynobius animal caps was compared with that of Xenopus and Cynops in relation to the structure of the animal caps.
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