論文

査読有り 国際誌
2020年6月2日

Vascular resistance of carotid and vertebral arteries is associated with retinal microcirculation measured by laser speckle flowgraphy in patients with type 2 diabetes mellitus.

Diabetes research and clinical practice
  • Shojiro Sawada
  • ,
  • Satoko Tsuchiya
  • ,
  • Shinjiro Kodama
  • ,
  • Satoko Kurosawa
  • ,
  • Akira Endo
  • ,
  • Hiroto Sugawara
  • ,
  • Shinichiro Hosaka
  • ,
  • Yohei Kawana
  • ,
  • Yoichiro Asai
  • ,
  • Junpei Yamamoto
  • ,
  • Yuichiro Munakata
  • ,
  • Tomohito Izumi
  • ,
  • Kei Takahashi
  • ,
  • Keizo Kaneko
  • ,
  • Junta Imai
  • ,
  • Azusa Ito
  • ,
  • Masayuki Yasuda
  • ,
  • Hiroshi Kunikata
  • ,
  • Toru Nakazawa
  • ,
  • Hideki Katagiri

開始ページ
108240
終了ページ
108240
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.diabres.2020.108240

AIMS: Evaluation of the retinal microcirculation is key to understanding retinal vasculopathies, such as diabetic retinopathy. Laser speckle flowgraphy (LSFG) has recently enabled us to directly evaluate the vascular resistance in both retinal vessels and capillaries, non-invasively. We therefore assessed whether retinal vessel blood flow and/or the capillary microcirculation are associated with blood flow in the cervical arteries in diabetic patients without severe retinopathy. METHODS: We enrolled 110 type 2 diabetes patients, with no or mild non-proliferative diabetic retinopathy, in this prospective cross-sectional study. We measured the resistivity indices (RIs) of the retinal vessel and capillaries by LSFG and those of cervical arteries by Doppler ultrasonography, followed by analyzing associations. RESULTS: The RIs of not only the carotid but also vertebral arteries were associated with those of retinal vessel blood flow and the retinal capillary microcirculation. Multiple regression analyses revealed these associations to be independent of other explanatory variables including age and diabetes duration. CONCLUSIONS: We obtained novel and direct evidence demonstrating a close association between the retinal microcirculation and cervical artery hemodynamics in diabetic patients. These findings suggest shared mechanisms to underlie micro- and macro-angiopathies. Thus, high vascular resistance of cervical arteries may be a risk of developing retinopathy.

リンク情報
DOI
https://doi.org/10.1016/j.diabres.2020.108240
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32502691

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