論文

査読有り 国際誌
2020年9月6日

Continuous glucose monitoring in patients with remission of type 2 diabetes after laparoscopic sleeve gastrectomy without or with duodenojejunal bypass.

Clinical obesity
  • Shojiro Sawada
  • ,
  • Shinjiro Kodama
  • ,
  • Satoko Tsuchiya
  • ,
  • Satoko Kurosawa
  • ,
  • Akira Endo
  • ,
  • Hiroto Sugawara
  • ,
  • Shinichiro Hosaka
  • ,
  • Yohei Kawana
  • ,
  • Yoichiro Asai
  • ,
  • Junpei Yamamoto
  • ,
  • Yuichiro Munakata
  • ,
  • Tomohito Izumi
  • ,
  • Kei Takahashi
  • ,
  • Keizo Kaneko
  • ,
  • Junta Imai
  • ,
  • Hirofumi Imoto
  • ,
  • Naoki Tanaka
  • ,
  • Takeshi Naitoh
  • ,
  • Yasushi Ishigaki
  • ,
  • Hideki Katagiri

開始ページ
e12409
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/cob.12409

Bariatric surgery is associated with a high remission rate of type 2 diabetes mellitus. However, it is unclear whether patients showing remission of diabetes actually have normal blood glucose levels throughout the day. We therefore performed continuous glucose monitoring (CGM) in 15 ambulatory patients showing remission of diabetes after laparoscopic sleeve gastrectomy (LSG) without or with duodenojejunal bypass (DJB) at the time of diabetic remission (12.9 ± 1.8 months after bariatric surgery). The definition of remission of diabetes was based on the American Diabetes Association criteria. The mean, SD, and coefficient of variation (CV) of glucose calculated from CGM were 6.2 ± 0.6 mmol/L, 1.5 ± 0.4 mmol/L, and 23.7 ± 6.2%, respectively. These values were higher than those of healthy participants without diabetes previously reported. The percentages of time spent above 10.0 mmol/L and below 3.9 mmol/L were 2.6 (IQR 0-5.0)% and 0 (IQR 0-8.0)%, respectively. Thus, patients with remission of diabetes after LSG or LSG/DJB still had substantial periods of hyperglycemia and hypoglycemia throughout the day. Therefore, we must manage patients with diabetes carefully, even after apparent remission of type 2 diabetes in response to bariatric surgery.

リンク情報
DOI
https://doi.org/10.1111/cob.12409
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32892484

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