Shotaro Shimonaka

Profile Information

Affiliation: Tokyo Metropolitan Institute of Medical Science

Researcher number: 90778747
J-GLOBAL ID: 201901001455571318
researchmap Member ID: B000375911

Research Areas

Life sciences / Pathobiochemistry /

Awards

Nov, 2023

第42回日本認知症学会学術集会学会奨励賞 (基礎研究部門), Tau-strainを区別する人工変異導入tauが持つ凝集阻害効果の検証, 日本認知症学会

Papers

α-Synuclein V15A Variant in Familial Parkinson's Disease Exhibits a Weaker Lipid-Binding Property.

Kensuke Daida, Shotaro Shimonaka, Kahori Shiba-Fukushima, Jun Ogata, Hiroyo Yoshino, Ayami Okuzumi, Taku Hatano, Yumiko Motoi, Tomoki Hirunagi, Masahisa Katsuno …

Movement disorders : official journal of the Movement Disorder Society, 37(10) 2075-2085, Jul 27, 2022
High-fat diet-induced activation of SGK1 promotes Alzheimer's disease-associated tau pathology.

Montasir Elahi, Yumiko Motoi, Shotaro Shimonaka, Yoko Ishida, Hiroyuki Hioki, Masashi Takanashi, Koichi Ishiguro, Yuzuru Imai, Nobutaka Hattori

Human molecular genetics, 30(18) 1693-1710, Aug 28, 2021
Strain-specific clearance of seed-dependent tau aggregation by lithium-induced autophagy.

Mohammad Nasir Uddin, Montasir Elahi, Shotaro Shimonaka, Soichiro Kakuta, Koichi Ishiguro, Yumiko Motoi, Nobutaka Hattori

Biochemical and biophysical research communications, 543 65-71, Mar 5, 2021 Peer-reviewed
α-Synuclein Seeding Assay Using Cultured Cells.

Jun Ogata, Daisaku Takemoto, Shotaro Shimonaka, Yuzuru Imai, Nobutaka Hattori

Methods in molecular biology (Clifton, N.J.), 2322 27-39, 2021
Learning Deficits Accompanied by Microglial Proliferation After the Long-Term Post-Injection of Alzheimer's Disease Brain Extract in Mouse Brains.

Tetsuo Hayashi, Shotaro Shimonaka, Montasir Elahi, Shin-Ei Matsumoto, Koichi Ishiguro, Masashi Takanashi, Nobutaka Hattori, Yumiko Motoi

Journal of Alzheimer's disease : JAD, 79(4) 1701-1711, 2021 Peer-reviewed
Asparagine residue 368 is involved in Alzheimer's disease tau strain–specific aggregation

Shotaro Shimonaka, Shin-Ei Matsumoto, Montasir Elahi, Koichi Ishiguro, Masato Hasegawa, Nobutaka Hattori, Yumiko Motoi

Journal of Biological Chemistry, 295(41) 13996-14014, Oct, 2020 Peer-reviewedLead author
Astrocytic 3-Repeat Tau Pathologies in Progressive Supranuclear Palsy.

Daisuke Taniguchi, Masashi Takanashi, Taku Hatano, Satsuki Kishikawa, Shotaro Shimonaka, Yumiko Motoi, Takashi Yao, Nobutaka Hattori

Journal of neuropathology and experimental neurology, 79(9) 1015-1018, Sep 1, 2020 Peer-reviewed
Tau aggregation and seeding analyses of two novel MAPT variants found in patients with motor neuron disease and progressive parkinsonism.

Nakayama S, Shimonaka S, Elahi M, Nishioka K, Oji Y, Matsumoto SE, Li Y, Yoshino H, Mogushi K, Hatano T …

Neurobiology of aging, 84 240.e13-240.e22, Mar, 2019 Peer-reviewed
Templated Aggregation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Seeding with TDP-43 Peptide Fibrils

Shotaro Shimonaka, Takashi Nonaka, Genjiro Suzuki, Shin-ichi Hisanaga, Masato Hasegawa

JOURNAL OF BIOLOGICAL CHEMISTRY, 291(17) 8896-8907, Apr, 2016 Peer-reviewed

Misc.

タウ蛋白伝播モデルマウスにおける行動および組織学的解析

林徹生, 本井ゆみ子, 下中翔太朗, モンタシル・エラヒ, 服部信孝

Dementia Japan, 32(3) 432-432, Sep, 2018
新規MAPT遺伝子変異臨床的および生化学的解析(New Mutations in the MAPT Gene: Clinical and Biochemical Characterization)

Nakayama Sachiko, Shimonaka Shotaro, Elahi Montasir, Oji Yutaka, Li Yuanzhe, Hiroyo Yoshino, Nishioka Kenya, Hatano Taku, Motoi Yumiko, Hattori Nobutaka

順天堂醫事雑誌, 63(6) 489-490, Dec, 2017
認知症・治療の展望タウ蛋白ターゲットの治療薬開発の展望世界の動向と我々の視点

本井ゆみ子, 林徹生, 下中翔太郎, 服部信孝

神経治療学, 34(6) S114-S114, Nov, 2017
Tauopathy培養細胞モデルを用いたTauの凝集・伝播に関わるアミノ酸配列の同定

下中翔太郎, 松本信英, 本井ゆみ子, 服部信孝

Dementia Japan, 31(4) 553-553, Oct, 2017

Presentations

Tau-strainを区別する人工変異導入tauが持つ凝集阻害効果の検証

下中翔太郎, 石黒幸一, 中村衣里, 多田昇弘, 本井ゆみ子, 服部信孝

第42回日本認知症学会学術集会, Nov 24, 2023
The molecular pathology of tau strain and anti-aggregation strategy

Shotaro Shimonaka

Oct 9, 2023
Tau-strainの分子病理と凝集阻害戦略

下中翔太郎

第41回日本認知症学会学術集会/第37回日本老年精神医学会 (合同開催), Nov 27, 2022

Teaching Experience

Sep, 2021 - Present

大学院講義神経医科学 (順天堂大学大学院)

Research Projects

Tauopathyにおける構造多型に着目したtau凝集の特異的阻害法開発

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2023 - Mar, 2026

下中翔太郎
各種Tauopathyにおいて特異的な凝集体を形成するtau単位配列の役割解明

科学研究費助成事業若手研究, 若手研究, 日本学術振興会, Apr, 2020 - Mar, 2023

下中翔太郎
The role of Alzheimer's disease risk factor PICALM on the propagation of Tau aggregates

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2021

Shimonaka Shotaro

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Papers

Misc.

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