2018年12月15日
Lambda Light Chain Non-crystalline Proximal Tubulopathy with IgD Lambda Myeloma.
Internal medicine (Tokyo, Japan)
- 巻
- 57
- 号
- 24
- 開始ページ
- 3597
- 終了ページ
- 3602
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.2169/internalmedicine.1323-18
Light Chain Proximal Tubulopathy (LCPT) is a rare form of paraprotein-related kidney disease in which monoclonal free light chains damage the proximal renal tubular epithelial cells. We herein report the case of a 78-year-old woman who presented with anemia and kidney dysfunction. Serum and urine protein electrophoresis analyses revealed a monoclonal IgD and λ free light chains. Proximal tubular injury and the accumulation of λ light chains were found by kidney biopsy. Electron microscopy revealed no organized structure suggestive of crystals. LCPT was caused by IgD lambda myeloma and bortezomib and dexamethasone therapy led to very good partial response (VGPR) without a worsening of the kidney function.
- リンク情報
- ID情報
-
- DOI : 10.2169/internalmedicine.1323-18
- ISSN : 0918-2918
- PubMed ID : 30101939
- PubMed Central 記事ID : PMC6355399