Daisuke Kyuno

Profile Information

Affiliation: 助教, 病理学第二講座, 札幌医科大学
: (Concurrent)

Degree: M.D. and Ph.D.(Mar, 2013, Sapporo Medical University)

Researcher number: 70563485
ORCID ID: https://orcid.org/0000-0003-4672-535X
J-GLOBAL ID: 201801012644604558
Researcher ID: Q-9268-2018
researchmap Member ID: B000307253

癌研究、消化器外科手術に関するトランスレーショナルな研究を積極的に実施したいと考えております。

Research Areas

Major Research History

Feb, 2020 - Present

Assistant professor, Department of Pathology, Sapporo Medical University

Education

Apr, 2009 - Mar, 2013

Graduate School of Medicine, Sapporo Medical University
Apr, 1999 - Mar, 2005

Sapporo Medical University

Awards

Papers

COVID-19-associated disseminated mucormycosis: An autopsy case report

Daisuke Kyuno, Terufumi Kubo, Mitsuhiro Tsujiwaki, Shintaro Sugita, Michiko Hosaka, Hazuki Ito, Keisuke Harada, Akira Takasawa, Yusaku Kubota, Kumi Takasawa, Yusuke Ono, Kazufumi Magara, Eichi Narimatsu, Tadashi Hasegawa, Makoto Osanai

World Journal of Clinical Cases, 10(28) 10358-10365, Oct 6, 2022
Disseminated mucormycosis in a patient with severe COVID-19 on venovenous extracorporeal membrane oxygenation: a case report.

Hazuki Ito, Ryuichiro Kakizaki, Keisuke Harada, Daisuke Kyuno, Terufumi Kubo, Naofumi Bunya, Takehiko Kasai, Shuji Uemura, Eichi Narimatsu

IDCases, e01578, Jul 19, 2022
Aberrant expression of claudin-6 contributes to malignant potentials and drug resistance of cervical adenocarcinoma.

Yui Ito, Akira Takasawa, Kumi Takasawa, Taro Murakami, Taishi Akimoto, Daisuke Kyuno, Yuka Kawata, Kodai Shano, Kurara Kirisawa, Misaki Ota, Tomoyuki Aoyama, Masaki Murata, Kotaro Sugimoto, Hideki Chiba, Tsuyoshi Saito, Makoto Osanai

Cancer science, 113(4) 1519-1530, Apr, 2022
Claudin-18.2 as a therapeutic target in cancers: cumulative findings from basic research and clinical trials.

Daisuke Kyuno, Akira Takasawa, Kumi Takasawa, Yusuke Ono, Tomoyuki Aoyama, Kazufumi Magara, Yuna Nakamori, Ichiro Takemasa, Makoto Osanai

Tissue barriers, 10(1) 1967080-1967080, Jan 2, 2022
Snapshots of lymphatic pathways in colorectal cancer surgery using near-infrared fluorescence, in vivo and ex vivo.

Yu Sato, Tetsuta Satoyoshi, Kenji Okita, Daisuke Kyuno, Atsushi Hamabe, Koichi Okuya, Toshihiko Nishidate, Emi Akizuki, Masayuki Ishii, Hiro-O Yamano, Shintaro Sugita, Hiroshi Nakase, Tadashi Hasegawa, Ichiro Takemasa

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 47(12) 3130-3136, Dec, 2021
A systemic apolipoprotein A-IV-associated amyloidosis confirmed by proteome analysis.

Taro Murakami, Akira Takasawa, Asako Moriki, Yusuke Igaki, Hiroshi Ikeda, Kazuyuki Murase, Kohichi Takada, Kazufumi Magara, Tomoyuki Aoyama, Yusuke Ono, Daisuke Kyuno, Kumi Takasawa, Masaki Murata, Makoto Osanai

Virchows Archiv : an international journal of pathology, 479(5) 1041-1046, Nov, 2021
Laparoscopic low anterior resection for rectal cancer wherein the inferior mesenteric artery arose from the superior mesenteric artery: a case report.

Takahiro Korai, Kenji Okita, Toshihiko Nishidate, Koichi Okuya, Emi Akizuki, Yu Sato, Atsushi Hamabe, Daisuke Kyuno, Masayuki Ishii, Ryo Miura, Masafumi Imamura, Minoru Nagayama, Takeshi Murakami, Takayuki Nobuoka, Tatsuya Ito, Ichiro Takemasa

Surgical case reports, 7(1) 179-179, Aug 11, 2021
Regulatory roles of claudin-1 in cell adhesion and microvilli formation

Kumi Takasawa, Akira Takasawa, Taishi Akimoto, Kazufumi Magara, Tomoyuki Aoyama, Hiroshi Kitajima, Taro Murakami, Yusuke Ono, Daisuke Kyuno, Hiromu Suzuki, Makoto Osanai

Biochemical and Biophysical Research Communications, 565 36-42, Aug, 2021
Perioperative Predictors of Early Recurrence for Resectable and Borderline-Resectable Pancreatic Cancer

Masafumi Imamura, Minoru Nagayama, Daisuke Kyuno, Shigenori Ota, Takeshi Murakami, Akina Kimura, Hiroshi Yamaguchi, Toru Kato, Yasutoshi Kimura, Ichiro Takemasa

Cancers, 13(10) 2285-2285, May, 2021
Role of tight junctions in the epithelial-to-mesenchymal transition of cancer cells.

Daisuke Kyuno, Akira Takasawa, Shin Kikuchi, Ichiro Takemasa, Makoto Osanai, Takashi Kojima

Biochimica et biophysica acta. Biomembranes, 1863(3) 183503-183503, Mar 1, 2021
Aberrant expression of junctional adhesion molecule-A contributes to the malignancy of cervical adenocarcinoma by interaction with poliovirus receptor/CD155.

Taro Murakami, Akira Takasawa, Kumi Takasawa, Taishi Akimoto, Tomoyuki Aoyama, Kazufumi Magara, Yuki Saito, Misaki Ota, Daisuke Kyuno, Soh Yamamoto, Tadashi Hasegawa, Tsuyoshi Saito, Makoto Osanai

Cancer science, 112(2) 906-917, Feb, 2021
Effect of Rikkunshito, a Traditional Japanese Herbal Medicine, on Delayed Gastric Emptying and Oral Dietary Intake After Pancreaticoduodenectomy: A Prospective, Randomized, Single-Center, Open-Labeled Study.

Hiroshi Yamaguchi, Yasutoshi Kimura, Masafumi Imamura, Minoru Nagayama, Tatsuya Ito, Daisuke Kyuno, Tsuyoshi Kono, Akina Kimura, Emi Akizuki, Toshihiko Nishidate, Kenji Okita, Takayuki Nobuoka, Toru Mizuguchi, Koichi Hirata, Ichiro Takemasa

Clinical and experimental gastroenterology, 13 577-587, Dec, 2020
Arteriovenous malformation in the pancreatic head initially mimicking a hypervascular mass treated with duodenum-preserving pancreatic head resection: a case report.

Korai T, Kimura Y, Imamura M, Nagayama M, Kanazawa A, Miura R, Murakami T, Kyuno D, Yamaguchi H, Terai K, Sugita S, Nobuoka T, Hasegawa T, Takemasa I

Surgical case reports, 6(1) 301-301, Dec, 2020
Endothelium capture‐based liver segment imaging using vascular endothelial growth factor receptor 2 in preclinical ex vivo models

D. Kyuno, B. Qian, W. Groß, M. Schäfer, E. Ryschich

BJS Open, Apr 22, 2020 Peer-reviewed
Glucose-Dependent FOXM1 Promotes Epithelial-to-Mesenchymal Transition Via Cellular Metabolism and Targeting Snail in Human Pancreatic Cancer

Takuro Kyuno, Takayuki Kohno, Takumi Konno, Hiroshi Yamaguchi, Daisuke Kyuno, Masafumi Imamura, Yasutoshi Kimura, Takashi Kojima, Ichiro Takemasa

PANCREAS, 49(2) 273-280, Feb, 2020 Peer-reviewed
Tricellular tight junction protein LSR/angulin-1 contributes to the epithelial barrier and malignancy in human pancreatic cancer cell line

Takuro Kyuno, Daisuke Kyuno, Takayuki Kohno, Takumi Konno, Shin Kikuchi, Chihiro Arimoto, Hiroshi Yamaguchi, Masafumi Imamura, Yasutoshi Kimura, Masuo Kondoh, Ichiro Takemasa, Takashi Kojima

HISTOCHEMISTRY AND CELL BIOLOGY, 153(1) 5-16, Jan, 2020 Peer-reviewed
Claudin7-dependent exosome-promoted reprogramming of nonmetastasizing tumor cells

Daisuke Kyuno, Kun Zhao, Martina Schnoelzer, Jan Provaznik, Thilo Hackert, Margot Zoeller

INTERNATIONAL JOURNAL OF CANCER, 145(8) 2182-2200, Oct, 2019 Peer-reviewed
Therapeutic Targeting Cancer-Initiating Cell Markers by Exosome miRNA: Efficacy and Functional Consequences Exemplified for claudin7 and EpCAM

Daisuke Kyuno, Kun Zhao, Nathalie Bauer, Eduard Ryschich, Margot Zoeller

TRANSLATIONAL ONCOLOGY, 12(2) 191-199, Feb, 2019 Peer-reviewed
Distinct Origin of Claudin7 in Early Tumor Endosomes Affects Exosome Assembly

Daisuke Kyuno, Nathalie Bauer, Martina Schnoelzer, Jan Provaznik, Eduard Ryschich, Thilo Hackert, Margot Zoeller

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 15(10) 2224-2239, 2019 Peer-reviewed
Liver segment imaging using monocyte sequestration: a potential tool for fluorescence-guided liver surgery

Baifeng Qian, Daisuke Kyuno, Michael Schaefer, Wolfgang Gross, Arianeb Mehrabi, Eduard Ryschich

THERANOSTICS, 8(22) 6101-6110, 2018 Peer-reviewed

Major Misc.

300

膵癌患者の予後と癌進展におけるJAM-Aの役割(Junctional Adhesion Molecule-A may play a role in the progression of pancreatic cancer)

及能大輔, 高澤啓, 高澤久美, 真柄和史, 小山内誠

日本癌学会総会記事, 81回 J-2053, Sep, 2022

Books and Other Publications

インフォームドコンセントのための図説シリーズ膵がん改訂3版

(Role: Contributor, 術後のフォローアップの方法)

Professional Memberships

Research Projects

Visualization of Cholangiocarcinoma Targeting Claudin 18.2 by Near-Infrared Fluorescently Labeled Antibody

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
経時的エクソソーム解析による膵癌術後早期再発ハイリスク症例診断法の開発

科学研究費助成事業基盤研究(C), 日本学術振興会, Apr, 2020 - Mar, 2023

今村将史, 永山稔, 竹政伊知朗, 及能大輔, 木村康利, 山口洋志
膵管内乳頭粘液性腫瘍の新規マウスモデルで発見された病態分子の臨床応用的機能解明

科学研究費助成事業基盤研究(C), 日本学術振興会, Apr, 2018 - Mar, 2022

山口洋志, 小島隆, 竹政伊知朗, 木村康利, 今村将史, 永山稔, 及能大輔
癌幹細胞マーカーSOX2に対する血中抗体を利用した乳癌の予後予測マーカーの開発と癌幹細胞標的療法の基盤的研究

令和元年度若手外科医のための臨床研究助成, 日本外科学会, Apr, 2020 - Apr, 2021

及能大輔, 竹政伊知朗, 九冨五郎, 島宏彰, 和田朝香, 里見蕗乃, 鳥越俊彦, 廣橋良彦
Use of VEGFR2 for NIR-guided liver segment labeling

Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity start-up, Japan Society for the Promotion of Science, Aug, 2019 - Mar, 2021
Development of a blood anti-SOX2 antibody assay for the early detection of breast cancer

2020 - 2021

Daisuke Kyuno, Makoto Osanai, Yosihiko Hirohashi, Tosihiko Torigoe, Asaka Wada, Hiroaki Shima, Goro Kutomi, Ichiro Takemasa
エクソソームmicroRNAによる膵癌再発予測マーカーの開発

令和元年度医学研究助成, 公益財団法人大阪難病研究財団, 2019 - 2020

及能大輔
膵癌に対する新規分子標的治療の基盤的研究

第22回海外交流助成, 伊藤医薬学術交流財団, 2016 - 2018

及能大輔
膵癌に対する新規分子標的治療の基盤的研究

ポストドクトラルフェローシップ, 上原記念生命科学財団, 2016 - 2017

及能大輔

Profile Information

Research Areas

Major Research History

Education

Awards

Papers

Major Misc.

Books and Other Publications

Professional Memberships

Research Projects

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