論文

査読有り
2017年8月

Neurosecretory protein GL stimulates food intake, de novo lipogenesis, and onset of obesity

ELIFE
  • Eiko Iwakoshi-Ukena
  • ,
  • Kenshiro Shikano
  • ,
  • Kunihiro Kondo
  • ,
  • Shusuke Taniuchi
  • ,
  • Megumi Furumitsu
  • ,
  • Yuta Ochi
  • ,
  • Tsutomu Sasaki
  • ,
  • Shiki Okamoto
  • ,
  • George E. Bentley
  • ,
  • Lance J. Kriegsfeld
  • ,
  • Yasuhiko Minokoshi
  • ,
  • Kazuyoshi Ukena

6
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.7554/eLife.28527
出版者・発行元
ELIFE SCIENCES PUBLICATIONS LTD

Mechanisms underlying the central regulation of food intake and fat accumulation are not fully understood. We found that neurosecretory protein GL (NPGL), a newly-identified neuropeptide, increased food intake and white adipose tissue (WAT) in rats. NPGL-precursor gene overexpression in the hypothalamus caused increases in food intake, WAT, body mass, and circulating insulin when fed a high calorie diet. Intracerebroventricular administration of NPGL induced de novo lipogenesis in WAT, increased insulin, and it selectively induced carbohydrate intake. Neutralizing antibody administration decreased the size of lipid droplets in WAT. Npgl mRNA expression was upregulated by fasting and low insulin levels. Additionally, NPGL-producing cells were responsive to insulin. These results point to NPGL as a novel neuronal regulator that drives food intake and fat deposition through de novo lipogenesis and acts to maintain steadystate fat level in concert with insulin. Dysregulation of NPGL may be a root cause of obesity.

Web of Science ® 被引用回数 : 7

リンク情報
DOI
https://doi.org/10.7554/eLife.28527
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28799896
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000407460100001&DestApp=WOS_CPL