2018年1月15日
Effects of chronic intracerebroventricular infusion of neurosecretory protein GL on body mass and food and water intake in chicks
General and Comparative Endocrinology
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- 巻
- 256
- 号
- 開始ページ
- 37
- 終了ページ
- 42
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.ygcen.2017.05.016
- 出版者・発行元
- Academic Press Inc.
Recently, we discovered a novel cDNA encoding the precursor of a small secretory protein, neurosecretory protein GL (NPGL), in the chicken mediobasal hypothalamus. In this study, immunohistochemical analysis revealed that NPGL was produced in the infundibular and medial mammillary nuclei of the mediobasal hypothalamus, with immunoreactive fibers also detected in the hypothalamus and the median eminence. As it is known that these regions are involved in feeding behavior in chicks, we surveyed the effects of chronic intracerebroventricular infusion of NPGL on feeding behavior and body mass for a period of two weeks. NPGL stimulated food and water intake, with a concomitant increase in body mass. However, NPGL did not influence mRNA expression of several hypothalamic ingestion-related neuropeptides. Our data suggest that NPGL may be a novel neuronal regulator involved in growth processes in chicks.
- リンク情報
- ID情報
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- DOI : 10.1016/j.ygcen.2017.05.016
- ISSN : 1095-6840
- ISSN : 0016-6480
- eISSN : 1095-6840
- PubMed ID : 28554734
- SCOPUS ID : 85020090466