2009年10月
beta-Catenin Signaling Levels in Progenitors Influence the Laminar Cell Fates of Projection Neurons
JOURNAL OF NEUROSCIENCE
- ,
- ,
- ,
- 巻
- 29
- 号
- 43
- 開始ページ
- 13710
- 終了ページ
- 13719
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1523/JNEUROSCI.3022-09.2009
- 出版者・発行元
- SOC NEUROSCIENCE
The mechanisms underlying the timing of the laminar fate decisions during cortical neurogenesis remain poorly understood. Here we show that beta-catenin signaling in cortical neural precursors can regulate the laminar fate of their daughters. In ventricular zone neural precursors, beta-catenin signaling is higher when deep-layer neurons are being generated and lower when upper-layer neurons are being generated. Overactivation of beta-catenin in cortical precursors midway through corticogenesis increased the relative production of deep-layer neurons, while inhibition of signaling increased the relative production of upper-layer neurons. Furthermore, in late-gestation upper-layer precursors, overactive beta-catenin signaling was able to partially restore production of deep-layer neurons. These observations suggest that increased beta-catenin signaling can reset the timing of cortical precursors to promote the production of deep-layer neurons, while inhibition of beta-catenin signaling advances the timing to promote upper-layer production.
- リンク情報
- ID情報
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- DOI : 10.1523/JNEUROSCI.3022-09.2009
- ISSN : 0270-6474
- PubMed ID : 19864583
- Web of Science ID : WOS:000271266600030