論文

査読有り
2009年10月

beta-Catenin Signaling Levels in Progenitors Influence the Laminar Cell Fates of Projection Neurons

JOURNAL OF NEUROSCIENCE
  • Christopher A. Mutch
  • ,
  • Nobuo Funatsu
  • ,
  • Edwin S. Monuki
  • ,
  • Anjen Chenn

29
43
開始ページ
13710
終了ページ
13719
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1523/JNEUROSCI.3022-09.2009
出版者・発行元
SOC NEUROSCIENCE

The mechanisms underlying the timing of the laminar fate decisions during cortical neurogenesis remain poorly understood. Here we show that beta-catenin signaling in cortical neural precursors can regulate the laminar fate of their daughters. In ventricular zone neural precursors, beta-catenin signaling is higher when deep-layer neurons are being generated and lower when upper-layer neurons are being generated. Overactivation of beta-catenin in cortical precursors midway through corticogenesis increased the relative production of deep-layer neurons, while inhibition of signaling increased the relative production of upper-layer neurons. Furthermore, in late-gestation upper-layer precursors, overactive beta-catenin signaling was able to partially restore production of deep-layer neurons. These observations suggest that increased beta-catenin signaling can reset the timing of cortical precursors to promote the production of deep-layer neurons, while inhibition of beta-catenin signaling advances the timing to promote upper-layer production.

リンク情報
DOI
https://doi.org/10.1523/JNEUROSCI.3022-09.2009
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/19864583
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000271266600030&DestApp=WOS_CPL
ID情報
  • DOI : 10.1523/JNEUROSCI.3022-09.2009
  • ISSN : 0270-6474
  • PubMed ID : 19864583
  • Web of Science ID : WOS:000271266600030

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