2020年9月21日
Imipenem plus fosfomycin as salvage therapy for vertebral osteomyelitis.
Antimicrobial agents and chemotherapy
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 65
- 号
- 1
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1128/AAC.01746-20
We applied combination antibiotic therapy to treat vertebral osteomyelitis and a psoas abscess caused by glycopeptide-intermediate (MIC, 2 μg/ml) and daptomycin-non-susceptible (>2 μg/ml) methicillin-resistant Staphylococcus aureus The Etest synergy test showed the largest synergistic effects for imipenem/cilastatin and fosfomycin. Whole-gene sequencing showed amino acid changes in SA0802, SA1193 (mprF), and SA1531 (ald). Four weeks of combination treatment using imipenem/cilastatin (1.5 g per day) and fosfomycin (4.0 g per day) resulted in clinical improvement.
- リンク情報
- ID情報
-
- DOI : 10.1128/AAC.01746-20
- PubMed ID : 32958715
- PubMed Central 記事ID : PMC7927830