2017年1月
Piceatannol exhibits anti-inflammatory effects on macrophages interacting with adipocytes
FOOD SCIENCE & NUTRITION
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 5
- 号
- 1
- 開始ページ
- 76
- 終了ページ
- 85
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/fsn3.366
- 出版者・発行元
- WILEY
Piceatannol (PIC), a natural analog of resveratrol (RES), is a phytochemical found in passion fruit seeds. To clarify the effects of PIC on obesity-induced inflammation in adipose tissue, we investigated the anti-inflammatory activity of PIC-related compounds (PIC, RES, and metabolites from PIC) in culture models of obese adipose tissue. Lipopolysaccharide (LPS) and conditioned medium from 3T3-L1 adipocytes (3T3-L1-CM) enhanced proinflammatory gene expression and synthesis of nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) in RAW264.7 macrophages. Although each compound inhibited the mRNA expression of iNOS (inducible NO synthase), TNF-alpha, and IL-6, PIC potently inhibited them, and 30 mu mol/L PIC suppressed the LPS- and 3T3-L1-CM-induced mRNA expression of iNOS (70.4% and 69.2% suppression, respectively), TNF-alpha (42.6% and 47.0% suppression), and IL-6 (27.3% and 42.1% suppression). PIC also significantly suppressed production of NO (80.3% suppression) and inflammatory cytokines (TNF-alpha; 33.7% suppression, IL-6; 66.5% suppression). Furthermore, PIC was found to rescue the uncoupling protein 1 mRNA expression induced by isoproterenol in 10T1/2 adipocytes, which was suppressed by LPS-activated macrophages. These results suggest that PIC may attenuate the pathologic inflammation triggered by adipose tissues.
- リンク情報
- ID情報
-
- DOI : 10.1002/fsn3.366
- ISSN : 2048-7177
- PubMed ID : 28070318
- Web of Science ID : WOS:000396371000008