2012年12月
Diet Enriched with Korean Pine Nut Oil Improves Mitochondrial Oxidative Metabolism in Skeletal Muscle and Brown Adipose Tissue in Diet-Induced Obesity
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 60
- 号
- 48
- 開始ページ
- 11935
- 終了ページ
- 11941
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/jf303548k
- 出版者・発行元
- AMER CHEMICAL SOC
In this study, we investigated effects of pine nut oil (PNO) on high-fat-diet (HFD)-induced obesity and metabolic dysfunction in skeletal muscle and brown adipose tissue (BAT). Male C57BL/6 mice were fed a HFD with 15% energy from lard and 30% energy from either soybean oil (SBO-HFD) or PNO (PNO-HFD) for 12 weeks. The PNO-HFD resulted in less weight gain and intramuscular lipid accumulation than the SBO-HFD and was accompanied by upregulation of transcripts and proteins related to oxidative metabolism and phosphorylation of AMP-activated protein kinase (AMPK), as well as molecules selectively expressed in type I and type IIa muscle fibers. In addition, uncoupling protein-1 was upregulated in BAT. These beneficial metabolic effects were partly associated with the dual ligand activity of pinolenic acid, which is abundant in PNO, for peroxisome proliferator-activated receptors alpha and delta. Our findings suggest that PNO may have potential as a dietary supplement for counteracting obesity and metabolic dysregulation.
- リンク情報
- ID情報
-
- DOI : 10.1021/jf303548k
- ISSN : 0021-8561
- PubMed ID : 23140571
- Web of Science ID : WOS:000311869800011