論文

査読有り 国際誌
2017年6月

Protein Complex of Fibrinogen Gamma Chain and Complement Factor H in Ovarian Cancer Patient Plasma.

Anticancer research
  • Ken-Ichi Honda
  • ,
  • Ryoko Asada
  • ,
  • Katsuhiro Kageyama
  • ,
  • Takeshi Fukuda
  • ,
  • Hiroyuki Terada
  • ,
  • Tomoyo Yasui
  • ,
  • Toshiyuki Sumi
  • ,
  • Masayasu Koyama
  • ,
  • Osamu Ishiko
  • ,
  • Tadashi Sugawa

37
6
開始ページ
2861
終了ページ
2866
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.21873/anticanres.11638
出版者・発行元
INT INST ANTICANCER RESEARCH

Background: In the plasma of an advanced cancer patient, fibrinogen is sometimes increased with possible effects on red blood cells (RBCs). Materials and Methods: The plasma fraction deteriorating osmotic resistance of RBCs was separated from a patient's plasma with advanced ovarian cancer by phenyl-sepharose column chromatography and analyzed with gel filtration chromatography. Results: In the plasma fraction, we found a protein reactive against whole fibrinogen with a molecular weight higher than that of intact fibrinogen from a healthy volunteer. The-high molecular weight protein was immunoractive to an antibody against fibrinogen gamma chain but not to an antibody against alpha or beta chain. Complement factor H, identified by N-terminal sequencing of a 150-kDa protein separated from the protein, was also eluted from anti-fibrinogen gamma immunoaffinity column. Conclusion: Fibrinogen gamma chain and complement factor H were found to be bound as a protein complex in the plasma of a patient with advanced ovarian cancer.

リンク情報
DOI
https://doi.org/10.21873/anticanres.11638
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28551622
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000402181600012&DestApp=WOS_CPL
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85019676176&origin=inward 本文へのリンクあり
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85019676176&origin=inward
ID情報
  • DOI : 10.21873/anticanres.11638
  • ISSN : 0250-7005
  • eISSN : 1791-7530
  • PubMed ID : 28551622
  • SCOPUS ID : 85019676176
  • Web of Science ID : WOS:000402181600012

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