2022年4月22日
Trehalose accumulation and radiation resistance due to prior heat stress in Saccharomyces cerevisiae.
Archives of microbiology
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- 巻
- 204
- 号
- 5
- 開始ページ
- 275
- 終了ページ
- 275
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s00203-022-02892-z
- 出版者・発行元
- SPRINGER
In this study, we examined the accumulation of trehalose, a stress-responsive substance, upon gamma-ray irradiation by evaluating the cause of trehalose accumulation and the development of gamma-ray resistance through intracellular trehalose accumulation. Saccharomyces cerevisiae cells cultured to the logarithmic growth phase were irradiated with gamma rays, and the intracellular trehalose content was measured. However, trehalose was not detectable. The yeast cells with trehalose accumulation caused by pre-treatment at 40 °C were irradiated with gamma rays, and the resistance of these cells to gamma radiation was compared with that of cells without heat treatment. Trehalose accumulation resulted in gamma-ray resistance and suppressed the increase in reactive oxygen species, lipid peroxidation, and DNA double-strand break production in yeast cells. The tests were also performed with a trehalose-6-phosphate-synthase (TPS1)-deficient mutant strain (Δtps1) unable to synthesize trehalose, and the results revealed that TPS1 was involved in protection against oxidative stress.
- リンク情報
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- DOI
- https://doi.org/10.1007/s00203-022-02892-z
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/35451658
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000785712700001&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85128605483&origin=inward
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85128605483&origin=inward
- ID情報
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- DOI : 10.1007/s00203-022-02892-z
- ISSN : 0302-8933
- eISSN : 1432-072X
- PubMed ID : 35451658
- SCOPUS ID : 85128605483
- Web of Science ID : WOS:000785712700001