論文

査読有り 国際誌
2018年3月

Allogeneic Hematopoietic Stem Cell Transplantation for Leukocyte Adhesion Deficiency.

Journal of pediatric hematology/oncology
  • Yasuo Horikoshi
  • ,
  • Katsutsugu Umeda
  • ,
  • Kohsuke Imai
  • ,
  • Hiromasa Yabe
  • ,
  • Yoji Sasahara
  • ,
  • Kenichiro Watanabe
  • ,
  • Yukiyasu Ozawa
  • ,
  • Yoshiko Hashii
  • ,
  • Hidemitsu Kurosawa
  • ,
  • Shigeaki Nonoyama
  • ,
  • Tomohiro Morio

40
2
開始ページ
137
終了ページ
140
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1097/MPH.0000000000001028

The clinical outcome of allogeneic hematopoietic stem cell transplantation (HSCT) was retrospectively analyzed in 6 patients with leukocyte adhesion deficiency. Of 3 patients transplanted with myeloablative conditioning, 2 patients had complete chimerism and 1 patient had mixed chimerism. By contrast, all 3 patients transplanted with reduced-intensity conditioning (RIC) had mixed chimerism, one of whom progressed to secondary graft failure. All patients with low-level mixed chimerism and secondary graft failure were rescued by donor lymphocyte infusion or a second HSCT. RIC-HSCT is feasible for leukocyte adhesion deficiency, although further refinement/modification of conditioning is required to achieve higher donor chimerism levels.

リンク情報
DOI
https://doi.org/10.1097/MPH.0000000000001028
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29324573