神谷宣広 (Nobuhiro Kamiya) - マイポータル

基本情報

所属: 天理大学体育学部体育学科教授

学位: 博士(岐阜大学)

通称等の別名: ノビー
研究者番号: 50735876
J-GLOBAL ID: 201801016777837372
researchmap会員ID: B000327445

外部リンク: https://www.tenri-u.ac.jp/teachers/q3tncs00000hxmm8.html

整形外科医として骨の研究を20年来しております！

研究キーワード

研究分野

受賞

2017年12月

平成29年度岐整会学術奨励賞, 岐阜大学整形外科同門会
2016年12月

最優秀ポスター賞, HIF-1-dependent IL-6 activation in articular chondrocytes as a mechanism for the initiation of hip synovitis following ischemic osteonecrosis of the femoral head, 日本小児整形外科学会

山口亮介、神谷宣広
2015年12月

最優秀ポスター賞, Legg-Calvé-Perthes Disease Produces Chronic Hip Synovitis and Elevation of Interleukin-6 in the Synovial Fluid, 日本小児整形外科学会
2014年5月

Charles T. Price Basic Science Paper Award, 北米小児整形外科学会
2013年9月

Russell A. Hibbs Science Award, 国際側弯症学会
2012年12月

研究助成賞, 国際側弯症学会
2012年5月

バイオメット研究助成賞, 北米小児整形外科学会
2011年8月

Charles T. Price Basic Science Paper Award, 北米小児整形外科学会

Harry Kim, Nobuhiro Kamiya
2010年8月

若手研究者研究助成賞, 国際側弯症学会
2008年7月

若手研究者賞, BMP国際研究会
2007年9月

旅費助成, 米国骨代謝学会
2007年9月

若手研究者優秀賞, 米国国立衛生研究所
2007年7月

第25回日本骨代謝学会優秀演題賞, 日本骨代謝学会
2007年3月

第12回日本軟骨代謝学会賞, 日本軟骨代謝学会
2006年9月

若手研究者賞, 米国骨代謝学会
2006年6月

若手研究者優秀賞, 米国国立衛生研究所
2004年3月

Lilly Foundation Award, 骨粗鬆症財団
2004年3月

研究助成, 日米医学医療交流財団
2003年3月

Fellowship Award, Gordon Research Conference
2003年3月

第17回研究交流助成, 金原一郎記念医学医療振興財団

主要な論文

Controversy of physiological vs. pharmacological effects of BMP signaling: Constitutive activation of BMP type IA receptor-dependent signaling in osteoblast lineage enhances bone formation and resorption, not affecting net bone mass.

Nobuhiro Kamiya, Phimon Atsawasuwan, Danese M Joiner, Erik I Waldorff, Steve Goldstein, Mitsuo Yamauchi, Yuji Mishina

Bone 138 115513-115513 2020年9月査読有り
Loss of BMP signaling mediated by BMPR1A in osteoblasts leads to differential bone phenotypes in mice depending on anatomical location of the bones.

Honghao Zhang, Yanshuai Zhang, Masahiko Terajima, Genevieve Romanowicz, Yangjia Liu, Maiko Omi, Erin Bigelow, Danese M Joiner, Erik I Waldorff, Peizhi Zhu …

Bone 137 115402-115402 2020年8月査読有り
COL5A1 rs12722 polymorphism is not associated with passive muscle stiffness and sports-related muscle injury in Japanese athletes.

Eri Miyamoto-Mikami, Naokazu Miyamoto, Hiroshi Kumagai, Kosuke Hirata, Naoki Kikuchi, Hirofumi Zempo, Noriko Kimura, Nobuhiro Kamiya, Hiroaki Kanehisa, Hisashi Naito …

BMC medical genetics 20(1) 192-192 2019年12月2日査読有り
An application of Dohsa Therapy for student-athletes as part of university counselling services

Emi Kaneko, Nobuhiro Kamiya, Yuhei Hatakenaka

BODY MOVEMENT AND DANCE IN PSYCHOTHERAPY 14(2) 66-79 2019年4月査読有り
ESR1 rs2234693 Polymorphism Is Associated with Muscle Injury and Muscle Stiffness.

Hiroshi Kumagai, Eri Miyamoto-Mikami, Kosuke Hirata, Naoki Kikuchi, Nobuhiro Kamiya, Seigo Hoshikawa, Hirofumi Zempo, Hisashi Naito, Naokazu Miyamoto, Noriyuki Fuku

Medicine and science in sports and exercise 51(1) 19-26 2019年1月査読有り
Genome-wide meta-analysis and replication studies in multiple ethnicities identify novel adolescent idiopathic scoliosis susceptibility loci.

Anas M Khanshour, Ikuyo Kou, Yanhui Fan, Elisabet Einarsdottir, Nadja Makki, Yared H Kidane, Juha Kere, Anna Grauers, Todd A Johnson, Nandina Paria …

Human molecular genetics 27(22) 3986-3998 2018年11月15日査読有り
Interleukin-6 deletion stimulates revascularization and new bone formation following ischemic osteonecrosis in a murine model.

Gen Kuroyanagi, Naga Suresh Adapala, Ryosuke Yamaguchi, Nobuhiro Kamiya, Zhuo Deng, Olumide Aruwajoye, Michael Kutschke, Elena Chen, Chanhee Jo, Yinshi Ren …

Bone 116 221-231 2018年11月査読有り
Targeted Disruption of NF1 in Osteocytes Increases FGF23 and Osteoid With Osteomalacia-like Bone Phenotype.

Nobuhiro Kamiya, Ryosuke Yamaguchi, Olumide Aruwajoye, Audrey J Kim, Gen Kuroyanagi, Matthew Phipps, Naga Suresh Adapala, Jian Q Feng, Harry Kw Kim

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 32(8) 1716-1726 2017年8月査読有り
Scleraxis-Lineage Cells Contribute to Ectopic Bone Formation in Muscle and Tendon.

Shailesh Agarwal, Shawn J Loder, David Cholok, Joshua Peterson, John Li, Christopher Breuler, R Cameron Brownley, Hsiao Hsin Sung, Michael T Chung, Nobuhiro Kamiya …

Stem cells (Dayton, Ohio) 35(3) 705-710 2017年3月査読有り
Elevated Fibroblast Growth Factor Signaling Is Critical for the Pathogenesis of the Dwarfism in Evc2/Limbin Mutant Mice.

Honghao Zhang, Nobuhiro Kamiya, Takehito Tsuji, Haruko Takeda, Greg Scott, Sudha Rajderkar, Manas K Ray, Yoshiyuki Mochida, Benjamin Allen, Veronique Lefebvre …

PLoS genetics 12(12) e1006510 2016年12月査読有り
Targeted disruption of BMP signaling through type IA receptor (BMPR1A) in osteocyte suppresses SOST and RANKL, leading to dramatic increase in bone mass, bone mineral density and mechanical strength.

Nobuhiro Kamiya, Lin Shuxian, Ryosuke Yamaguchi, Matthew Phipps, Olumide Aruwajoye, Naga Suresh Adapala, Hui Yuan, Harry K W Kim, Jian Q Feng

Bone 91 53-63 2016年10月査読有り
Ellis Van Creveld2 is Required for Postnatal Craniofacial Bone Development.

Mohammed K Badri, Honghao Zhang, Yoshio Ohyama, Sundharamani Venkitapathi, Nobuhiro Kamiya, Haruko Takeda, Manas Ray, Greg Scott, Takehito Tsuji, Tetsuo Kunieda …

Anatomical record (Hoboken, N.J. : 2007) 299(8) 1110-20 2016年8月査読有り
Expression of Evc2 in craniofacial tissues and craniofacial bone defects in Evc2 knockout mouse.

Mohammed K Badri, Honghao Zhang, Yoshio Ohyama, Sundharamani Venkitapathi, Ahmed Alamoudi, Nobuhiro Kamiya, Haruko Takeda, Manas Ray, Greg Scott, Takehito Tsuji …

Archives of oral biology 68 142-52 2016年8月査読有り
HIF-1-Dependent IL-6 Activation in Articular Chondrocytes Initiating Synovitis in Femoral Head Ischemic Osteonecrosis.

Ryosuke Yamaguchi, Nobuhiro Kamiya, Naga Suresh Adapala, Hicham Drissi, Harry K W Kim

The Journal of bone and joint surgery. American volume 98(13) 1122-31 2016年7月6日査読有り
Loss of BMP signaling through BMPR1A in osteoblasts leads to greater collagen cross-link maturation and material-level mechanical properties in mouse femoral trabecular compartments.

Yanshuai Zhang, Erin Gatenby McNerny, Masahiko Terajima, Mekhala Raghavan, Genevieve Romanowicz, Zhanpeng Zhang, Honghao Zhang, Nobuhiro Kamiya, Margaret Tantillo, Peizhi Zhu …

Bone 88 74-84 2016年7月査読有り
In vivo monitoring of activated macrophages and neutrophils in response to ischemic osteonecrosis in a mouse model

Matthew C. Phipps, YiHui Huang, Ryosuke Yamaguchi, Nobuhiro Kamiya, Naga S. Adapala, Liping Tang, Harry K. W. Kim

JOURNAL OF ORTHOPAEDIC RESEARCH 34(2) 307-313 2016年2月査読有り
SHP2-Deficiency in Chondrocytes Deforms Orofacial Cartilage and Ciliogenesis in Mice

Nobuhiro Kamiya, Jingling Shen, Kazuo Noda, Megumi Kitami, Gen-Sheng Feng, Di Chen, Yoshihiro Komatsu

JOURNAL OF BONE AND MINERAL RESEARCH 30(11) 2028-2032 2015年11月査読有り
Generation of Evc2/Limbin Global and Conditional KO Mice and Its Roles during Mineralized Tissue Formation

Honghao Zhang, Haruko Takeda, Takehito Tsuji, Nobuhiro Kamiya, Sudha Rajderkar, Ke'Ale Louie, Crystal Collier, Greg Scott, Manas Ray, Yoshiyuki Mochida …

GENESIS 53(9) 612-626 2015年9月査読有り
Legg-Calvé-Perthes disease produces chronic hip synovitis and elevation of interleukin-6 in the synovial fluid.

Kamiya N, Yamaguchi R, Adapala NS, Chen E, Neal D, Jack O, Thoveson A, Gudmundsson P, Brabham C, Aruwajoye O …

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 30(6) 1009-1013 2015年6月査読有り
Development of a Mouse Model of Ischemic Osteonecrosis

Nobuhiro Kamiya, Ryosuke Yamaguchi, Olumide Aruwajoye, Naga Suresh Adapala, Harry K. W. Kim

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH 473(4) 1486-1498 2015年4月査読有り
A PAX1 enhancer locus is associated with susceptibility to idiopathic scoliosis in females

Swarkar Sharma, Douglas Londono, Walter L. Eckalbar, Xiaochong Gao, Dongping Zhang, Kristen Mauldin, Ikuyo Kou, Atsushi Takahashi, Morio Matsumoto, Nobuhiro Kamiya …

NATURE COMMUNICATIONS 6 6452-6452 2015年3月査読有り
Mechanical Loading Synergistically Increases Trabecular Bone Volume and Improves Mechanical Properties in the Mouse when BMP Signaling Is Specifically Ablated in Osteoblasts.

Ayaka Iura, Erin Gatenby McNerny, Yanshuai Zhang, Nobuhiro Kamiya, Margaret Tantillo, Michelle Lynch, David H Kohn, Yuji Mishina

PloS one 10(10) e0141345 2015年査読有り
Neurofibromin Deficiency-Associated Transcriptional Dysregulation Suggests a Novel Therapy for Tibial Pseudoarthrosis in NF1

Nandina Paria, Tae-Joon Cho, In Ho Choi, Nobuhiro Kamiya, Kay Kayembe, Rong Mao, Rebecca L. Margraf, Gerlinde Obermosser, Ila Oxendine, David W. Sant …

JOURNAL OF BONE AND MINERAL RESEARCH 29(12) 2636-2642 2014年12月査読有り
Regulation of bone and skeletal development by the SHP-2 protein tyrosine phosphatase

Nobuhiro Kamiya, Harry K. W. Kim, Philip D. King

BONE 69 55-60 2014年12月査読有り
Local Administration of Bone Morphogenetic Protein-2 and Bisphosphonate During Non-Weight-Bearing Treatment of Ischemic Osteonecrosis of the Femoral Head An Experimental Investigation in Immature Pigs

Harry K. W. Kim, Olumide Aruwajoye, Justin Du, Nobuhiro Kamiya

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME 96A(18) 1515-1524 2014年9月査読有り
Role of Ellis-van Creveld syndrome2 (Evc2) in craniofacial development

Mohammed K. Badri, Honghao Zhang, Nobuhiro Kamiya, Takehito Tsuji, Tetsuo Kunieda, Yuji Mishina, Yoshiyuki Mochida

AMERICAN JOURNAL OF MEDICAL GENETICS PART A 164(8) 1876-1877 2014年8月査読有り
Targeted Disruption of Shp2 in Chondrocytes Leads to Metachondromatosis With Multiple Cartilaginous Protrusions

Harry K. W. Kim, Gen-Sheng Feng, Di Chen, Philip D. King, Nobuhiro Kamiya

JOURNAL OF BONE AND MINERAL RESEARCH 29(3) 761-769 2014年3月査読有り
Somatic Neurofibromin Deficiency and Transcriptional Dysregulation in Tibial Pseudoarthrosis with Neurofibromatosis Type 1.

Nandina Paria, Tae-Joon Cho, In Ho Choi, Nobuhiro Kamiya, Kay Kayembe, Rong Mao, Rebecca Margraf, Gerlinde Obermosser, Ila Oxendine, David Sant …

JOURNAL OF BONE AND MINERAL RESEARCH 29 S389-S389 2014年2月査読有り
BMP2 and ibandronate combination therapy improves bone healing during non-weight bearing treatment of ischemic osteonecrosis of the femoral head.

Olumide Aruwajoye, Justin Du, Nobuhiro Kamiya, Harry Kim

JOURNAL OF BONE AND MINERAL RESEARCH 29 S156-S157 2014年2月査読有り
Deletion of SHP-2 in mesenchymal stem cells causes growth retardation, limb and chest deformity, and calvarial defects in mice

Philip E. Lapinski, Melissa F. Meyer, Gen-Sheng Feng, Nobuhiro Kamiya, Philip D. King

DISEASE MODELS & MECHANISMS 6(6) 1448-1458 2013年11月査読有り
Induction of SHP2 Deficiency in Chondrocytes Causes Severe Scoliosis and Kyphosis in Mice

Harry K. W. Kim, Olumide Aruwajoye, Daniel Sucato, B. Stephens Richards, Gen-Sheng Feng, Di Chen, Philip D. King, Nobuhiro Kamiya

SPINE 38(21) E1307-E1312 2013年10月査読有り
Augmentation of smad-dependent BMP signaling in neural crest cells causes craniosynostosis in mice

Yoshihiro Komatsu, Paul B. Yu, Nobuhiro Kamiya, Haichun Pan, Tomokazu Fukuda, Gregory J. Scott, Manas K. Ray, Ken-ichi Yamamura, Yuji Mishina

JOURNAL OF BONE AND MINERAL RESEARCH 28(6) 1422-1433 2013年6月査読有り
High-concentration of BMP2 reduces cell proliferation and increases apoptosis via DKK1 and SOST in human primary periosteal cells

Harry K. W. Kim, Ila Oxendine, Nobuhiro Kamiya

BONE 54(1) 141-150 2013年5月査読有り
Acute BMP2 upregulation following induction of immature femoral head ischemic osteonecrosis in

Nobuhiro Kamiya, Sasha Shafer, Ila Oxendine, Douglas P. Mortlock, Ronald L. Chandler, Leif Oxburgh, Harry K. W. Kim

BONE 53(1) 239-247 2013年3月査読有り
Lactoferrin activates BMP7 gene expression through the mitogen-activated protein kinase ERK pathway in articular cartilage

Chi Zhang, Yang Li, Wanjin Tang, Nobuhiro Kamiya, Harry Kim

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 431(1) 31-35 2013年2月査読有り
BMP Receptor 1A Determines the Cell Fate of the Postnatal Growth Plate

Junjun Jing, Yinshi Ren, Zhaowen Zong, Chuanju Liu, Nobuhiro Kamiya, Yuji Mishina, Ying Liu, Xuedong Zhou, Jian Q. Feng

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 9(9) 895-906 2013年査読有り
The role of BMPs in bone anabolism and their potential targets SOST and DKK1.

Nobuhiro Kamiya

Current molecular pharmacology 5(2) 153-63 2012年6月査読有り
A Wnt-Bmp Feedback Circuit Controls Intertissue Signaling Dynamics in Tooth Organogenesis

Daniel J. O'Connell, Joshua W. K. Ho, Tadanori Mammoto, Annick Turbe-Doan, Joyce T. O'Connell, Psalm S. Haseley, Samuel Koo, Nobuhiro Kamiya, Donald E. Ingber, Peter J. Park …

SCIENCE SIGNALING 5(206) ra4 2012年1月査読有り
Conditional Deletion of Bmpr1a in Differentiated Osteoclasts Increases Osteoblastic Bone Formation, Increasing Volume of Remodeling Bone in Mice

Mina Okamoto, Junko Murai, Yuuki Imai, Daisuke Ikegami, Nobuhiro Kamiya, Shigeaki Kato, Yuji Mishina, Hideki Yoshikawa, Noriyuki Tsumaki

JOURNAL OF BONE AND MINERAL RESEARCH 26(10) 2511-2522 2011年10月査読有り
Loss-of-function of ACVR1 in osteoblasts increases bone mass and activates canonical Wnt signaling through suppression of Wnt inhibitors SOST and DKK1

Nobuhiro Kamiya, Vesa M. Kaartinen, Yuji Mishina

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 414(2) 326-330 2011年10月査読有り
Augmentation of Smad-dependent BMP signaling in cranial neural crests causes craniosynostosis in mice

Yoshihiro Komatsu, Paul Yu, Nobuhiro Kamiya, Yuji Mishina

DEVELOPMENTAL BIOLOGY 356(1) 162-162 2011年8月査読有り
Local Administration of Ibandronate and Bone Morphogenetic Protein-2 After Ischemic Osteonecrosis of the Immature Femoral Head A Combined Therapy That Stimulates Bone Formation and Decreases Femoral Head Deformity

Jacob S. Vandermeer, Nobuhiro Kamiya, James Aya-ay, Amanda Garces, Richard Browne, Harry K. W. Kim

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME 93A(10) 905-913 2011年5月査読有り
Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations

Timothy J. Bauler, Nobuhiro Kamiya, Philip E. Lapinski, Eric Langewisch, Yuji Mishina, John E. Wilkinson, Gen-Sheng Feng, Philip D. King

DISEASE MODELS & MECHANISMS 4(2) 228-U112 2011年3月査読有り
New insights on the roles of BMP signaling in bone-A review of recent mouse genetic studies

Nobuhiro Kamiya, Yuji Mishina

BIOFACTORS 37(2) 75-82 2011年3月査読有り
Wnt Inhibitors Dkk1 and Sost Are Downstream Targets of BMP Signaling Through the Type IA Receptor (BMPRIA) in Osteoblasts

Nobuhiro Kamiya, Tatsuya Kobayashi, Yoshiyuki Mochida, Paul B. Yu, Mitsuo Yamauchi, Henry M. Kronenberg, Yuji Mishina

JOURNAL OF BONE AND MINERAL RESEARCH 25(2) 200-210 2010年2月査読有り
Nuclear xenobiotic receptor PXR-null mouse exhibits hypophosphatemia and represses the Na/Pi-cotransporter SLC34A2

Yoshihiro Konno, Rick Moore, Nobuhiro Kamiya, Masahiko Negishi

PHARMACOGENETICS AND GENOMICS 20(1) 9-17 2010年1月査読有り
Nuclear Xenobiotic Receptor Pregnane X Receptor Locks Corepressor Silencing Mediator for Retinoid and Thyroid Hormone Receptors (SMRT) onto the CYP24A1 Promoter to Attenuate Vitamin D-3 Activation

Yoshihiro Konno, Susumu Kodama, Rick Moore, Nobuhiro Kamiya, Masahiko Negishi

MOLECULAR PHARMACOLOGY 75(2) 265-271 2009年2月査読有り
BMP type I receptor inhibition reduces heterotopic ossification

Paul B. Yu, Donna Y. Deng, Carol S. Lai, Charles C. Hong, Gregory D. Cuny, Mary L. Bouxsein, Deborah W. Hong, Patrick M. McManus, Takenobu Katagiri, Chetana Sachidanandan …

NATURE MEDICINE 14(12) 1363-1369 2008年12月査読有り
Disruption of BMP Signaling in Osteoblasts Through Type IA Receptor (BMPRIA) Increases Bone Mass

Nobuhiro Kamiya, Ling Ye, Tatsuya Kobayashi, Donald J. Lucas, Yoshiyuki Mochida, Mitsuo Yamauchi, Henry M. Kronenberg, Jian Q. Feng, Yuji Mishina

JOURNAL OF BONE AND MINERAL RESEARCH 23(12) 2007-2017 2008年12月査読有り
BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway

Nobuhiro Kamiya, Ling Ye, Tatsuya Kobayashi, Yoshiyuki Mochida, Mitsuo Yamauchi, Henry M. Kronenberg, Jian Q. Feng, Yuji Mishina

DEVELOPMENT 135(22) 3801-3811 2008年11月査読有り

もっとみる

主要なMISC

軟骨分化におけるシグナル伝達

渡辺秀人, 神谷宣広, 蛯沢克己, 木全弘治

マトリックス研究会大会 (50) 84-84 2003年3月査読有り

もっとみる

共同研究・競争的資金等の研究課題

小児大腿骨頭壊死症のIL-6を中心とした分子病態の解明と新規治療法の創出

日本学術振興会科学研究費助成事業基盤研究(C) 基盤研究(C) 2019年4月 - 2023年3月

神谷宣広, 黒柳元
小児大腿骨頭壊死症に対する基礎研究

日本学術振興会科学研究費助成事業基盤研究(C) 基盤研究(C) 2015年4月 - 2018年3月

神谷宣広
ペルテス病(小児大腿骨頭壊死症）の分子レベルでの病態解析

日本学術振興会科学研究費助成事業研究活動スタート支援研究活動スタート支援 2014年8月 - 2015年3月

神谷宣広

神谷宣広

基本情報

研究キーワード

研究分野

受賞

主要な論文

主要なMISC

共同研究・競争的資金等の研究課題

メニュー

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