論文

国際誌
2022年3月4日

Dynamics of salivary human herpesvirus-6 and -7 shedding in pregnant women.

Journal of medical virology
  • Noriko Suzuki
  • Masaru Ihira
  • Yasuko Enya
  • Takahashi Yumi
  • Chisato Izuru
  • Igarashi Rie
  • Yuki Higashimoto
  • Miura Hiroki
  • Takanashi Asaki
  • Fujimoto Kaoru
  • Yoshiki Kawamura
  • Tetsushi Yoshikawa
  • 全て表示

94
7
開始ページ
3359
終了ページ
3367
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/jmv.27692

Reactivation of Betaherpesvirinae (Human herpesvirus 6A: HHV-6A, -6B, HHV-7) may be associated with mental illness and host fatigue. This study aimed to determine whether viral reactivation, measured by monitoring salivary viral DNA load, can be used to monitor depression in pregnant and postpartum women. Saliva samples were collected from 64 pregnant women at five points of observation periods. The HHV-6- and HHV-7-specific qPCRs were carried out to measure viral DNA load. When HHV-6 DNA was detected in saliva, nested PCR was used to discriminate between HHV-6A and -6B. In both viruses, a significant correlation was observed between detection frequency and viral DNA load in saliva. In the low-shedding group, HHV-6 DNA was significantly higher in the third trimester (p < 0.0001), the time of delivery (p = 0.0003), 1 month after birth (p = 0.0023) compared with the first trimester, and HHV-7 was at the time of delivery (p = 0.0277) and 1 month after birth (p = 0.0235). Most of the detected HHV-6 DNAs in saliva were HHV-6B. Both viral DNA loads were significantly lower (HHV-6: p = 0.0101, HHV-7: p = 0.0044) in the subjects with abnormal Edinburgh Postnatal Depression Scale (EPDS) scores. The detection rate and viral DNA load of both viruses in saliva increased after the third trimester. Salivary virus DNA shedding was significantly lower in subjects with an abnormal EPDS score.

リンク情報
DOI
https://doi.org/10.1002/jmv.27692
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/35243652
ID情報
  • DOI : 10.1002/jmv.27692
  • PubMed ID : 35243652

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